Study to Assess the Efficacy, Safety, and Tolerability of Vixarelimab in Reducing Pruritus in Prurigo...
Prurigo NodularisPruritisStudy of the efficacy, safety, tolerability, pharmacokinetics (PK), and immunogenicity of Vixarelimab (KPL-716) in subjects with prurigo nodularis.
A Randomized Placebo-Controlled Study of the Neurokinin-1 (NK1) Receptor Antagonist Serlopitant...
Prurigo NodularisThe purpose of this study is to demonstrate whether or not VPD-737, an NK1 receptor antagonist is safe and effective for treatment of prurigo nodularis versus placebo.
Open Label Extension Study of Nalbuphine HCl ER in Patients With Prurigo Nodularis
Prurigo NodularisNodularis Prurigo1 moreThe primary objective of the study is to evaluate the overall safety of nalbuphine HCL ER tablets during a treatment period of up to 50 weeks.
Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch)...
PruritusPrurigo NodularisStudy of the efficacy, safety, and tolerability of serlopitant for the treatment of pruritus in adults with prurigo nodularis
A Study of CDX-0159 in Patients With Prurigo Nodularis
Prurigo NodularisThe purpose of the study is to explore the safety, clinical effect, pharmacodynamics, and pharmacokinetics of CDX-0159 (barzolvolimab) in patients with Prurigo Nodularis.
Real-World Effectiveness of Dupilumab in Patients With Prurigo Nodularis: An Observational Study...
Prurigo NodularisThis study is a prospective, multinational, observational investigation designed to elucidate the real-world effectiveness and treatment patterns of dupilumab therapy in adult patients diagnosed with prurigo nodularis (PN). The primary objective of this study is to comprehensively characterize the real-world usage of dupilumab for the management of PN. In addition to this, the study aims to achieve several secondary objectives, including a detailed assessment of the medical history, socio-demographic and disease characteristics of dupilumab-treated PN patients, as well as the evaluation of the long-term real-world effectiveness of dupilumab therapy for PN.
Safety and Efficacy of CC-10004 for Prurigo Nodularis
Prurigo NodularisThis trial will include: Study period up to 7 months. Office visits monthly lasting approximately 1 hour. Blood Draws. Oral medication that is taken 2 times daily. Photographs and biopsies if agreed.
Pain Outcomes Following Intralesional Corticosteroid Injections
KeloidAlopecia Areata13 moreCorticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics. However, these injections can be quite painful, which leads many patients to discontinue treatment. Often, the injection involves a mixture of local anesthetic and corticosteroids despite a lack of evidence that the use of lidocaine improves pain. Due to the acidic pH, the lidocaine component of the injection can actually cause a significant burning sensation during the procedure. Lidocaine does not have anti-inflammatory properties and does not treat the underlying pathology. By including another medication, lidocaine also adds cost and risk to the procedure. The purpose of this study is to see if removing lidocaine from intralesional injections decreases the pain of injection.
Topical Aprepitant in Prurigo Patients
PruritusTopical Aprepitant in Prurigo Patients - An Exploratory Phase IIa Trial With Topically Applied Aprepitant in Patients With Prurigo
Apremilast as Anti-pruritic Treatment in Patients With Prurigo Nodularis
Prurigo NodularisThis study will evaluate the anti-pruritic effect of apremilast in patients with known PN.