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Active clinical trials for "Pruritus"

Results 61-70 of 264

Treatment of Cholestatic Pruritus With Sertraline

PruritusLiver Cirrhosis2 more

The goal of this study is to find an effective and well-tolerated medical therapy for itching due to liver disease. Persons with primary biliary cirrhosis or chronic hepatitis C are currently being enrolled in the study. Persons participating in the study are given sertraline, a medication which is also often used for depression,to treat their itching. The dose is gradually increased as the effect on itching and any other potential side effects are carefully monitored.

Completed3 enrollment criteria

Treatment of Chronic Itch in Patients Under Arsenic Exposure With Sublingual Naloxone

Chronic Pruritus

The purpose of this study is to assess the efficacy and safety of sublingual naloxone in the treatment of chronic itch in patients under arsenic exposure.

Completed22 enrollment criteria

A Neurokinin-1 Receptor Antagonist for the Treatment of Pruritus in Patients With Epidermolysis...

Epidermolysis Bullosa

To determine if Serlopitant (when taken by mouth) is safe and works on itch in patients aged 13 and above with EB.

Completed26 enrollment criteria

Does IV Ondansetron Prevent Pruritus After Intrathecal Morphine in Pediatric Patients?

PruritusNausea/Vomiting

This is a prospective randomized, double-blind, placebo-controlled study to compare the incidence and intensity of ITM-induced pruritus and nausea/vomiting using pre-emptive IV ondansetron, followed by scheduled Around The Clock (ATC) ondansetron vs. our control group, where pruritus and PONV are treated with PRN only medications.

Terminated10 enrollment criteria

Effects of High-concentration Topical Capsaicin on Histaminergic and Non-histaminergic Itch

Pruritus

The purpose of this project is to investigate the effect of capsaicin-induced neurogenic inflammation with three different intensities on itch subsequently induced by histamine and cowhage. The hypothesis is that capsaicin-induced pre-established neurogenic inflammation significantly increases susceptibility to itch provocations with cowhage and histamine.

Completed15 enrollment criteria

B244 Topical Spray for the Treatment of Pruritus in Adults With a History of Atopic Dermatitis

Atopic Dermatitis

This is a double-blind, randomized, vehicle-controlled study to assess the efficacy, safety, and tolerability of 2 doses of B244 for the treatment of pruritus in adults with a history of atopic dermatitis. Subjects who meet the study entry criteria will be randomized in a 1:1:1 ratio to receive twice daily topical doses of B244 O.D. 5.0, B244 O.D. 20.0, or vehicle (placebo) for 4 weeks.

Completed33 enrollment criteria

AST-120 in Hemodialysis Patients With Uremic Pruritus

Uremic Pruritus

The prevalence of cutaneous pruritus among hemodialysis patients is about 50% to 80%. There is only a handful of studies on the itchy skin of hemodialysis patients and the findings are to be validated. Effective drugs to treat cutaneous pruritus are not available yet. Hence, the purpose of the study is to eliminate the uremic toxins from the intestinal tract using AST-120 as a treatment measure to improve the symptom of the hemodialysis patients' cutaneous pruritus and discuss and assess its effectiveness. For this, the investigators will recruit 150 patients to validate the application potential of the AST-120 in the cutaneous pruritus brought about by uremia.

Completed21 enrollment criteria

Digital Strategies for Patients With Chronic Dermatosis With Pruritus / Skin Picking Disorder

Skin-PickingAcne1 more

Almost 35% of patients treated to dermatosis have some psychiatric disorder. The aim of this study is to evaluate the prevalence and severity of skin picking disorder and other dermatosis, and also test the efficacy of an online-delivered cognitive-behavioral therapy to improve skin picking disorder severity.

Completed6 enrollment criteria

Gabapentin Versus Loratadine in Uremic Pruritus

PruritusUremia1 more

The goal of this clinical trial is to compare the efficacy of gabapentin with loratadine in reducing the severity of uremic pruritus in patients of chronic kidney disease and to compare the side effects of both drugs. The main questions it aims to answer are: Which drug (gabapentin versus loratadine) is more effective in reducing the severity of uremic pruritus? Which drug (gabapentin versus loratadine) has fewer side effects? Participants were divided into two groups.Group A received loratadine 10mg daily and group B received gabapentin 100mg daily. Both groups were given treatment for 4 weeks. Participants were asked to grade the severity of pruritus on a numerical rating scale and also answer the Dermatology Life Quality Index Questionnaire (DLQI) Participants were also asked to report any side effects, if occurred. Researchers compared both groups with regards to improvement in pruritus severity, DLQI score and side effects.

Completed7 enrollment criteria

Bioavailability and Tolerability of Fexofenadine Hydrochloride Topical Lotion 1%

Atopic DermatitisAtopic Dermatitis Eczema10 more

The investigational lotion is envisaged as an short- and long term "Ease & Prevent" monotherapy for adults and children with mild to moderate eczema. With itch representing the most burdensome symptom in eczema, the main objectives with the lotion is fast and efficient itch relief, high tolerability, and high short- and long term safety. This phase 1 study aims to monitor skin tolerability, and how much of the active compound that is absorbed to the bloodstream.

Completed22 enrollment criteria
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