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Active clinical trials for "Pulmonary Aspergillosis"

Results 41-50 of 80

Isavuconazole for the Prevention of COVID-19-associated Pulmonary Aspergillosis

Severe Acute Respiratory Syndrome Coronavirus 2Aspergillosis Invasive

The objective of this study is to evaluate whether antifungal prophylaxis with isavuconazole can reduce the incidence of SARS-CoV-2-associated invasive aspergillosis in patients in the ICU (intensive care unit) with severe COVID-19 infection. The investigators will perform an interventional, double-blinded, randomized-controlled, multi-center study in patients with severe COVID-19 infection admitted to the ICU. Patients will be randomized to the isavuconazole prophylaxis plus standard of care (SOC) group or the placebo plus SOC group. Participants will receive isavuconazole or placebo for up to 28 days or until discharge from the hospital (whichever occurs first).

Terminated19 enrollment criteria

Evaluation of a Therapeutic Strategy Including Nebulised Liposomal Amphotericin B (Ambisome®) in...

Allergic Bronchopulmonary Aspergillosis

Compare the incidence of severe clinical exacerbations in the treatment of ABPA, between a strategy with a maintenance treatment and a conventional strategy without antifungal maintenance therapy.

Completed16 enrollment criteria

Voriconazole And Anidulafungin Combination For Invasive Aspergillosis In Pediatric Subjects

AspergillosisInvasive Pulmonary Aspergillosis1 more

This study aims to compare the safety, tolerability, and efficacy of voriconazole and anidulafungin in combination versus voriconazole alone in pediatric subjects aged 2 to 17 years with invasive aspergillosis.

Withdrawn6 enrollment criteria

Nebulized Liposomal Amphotericin B Ambisome for Prophylaxis of Invasive Pulmonary Aspergillosis...

Acute Myeloid LeukemiaAllogeneic Haematopoietic Progenitor Cell Transplant

The trial is planned as a multicentric, national, phase II, open-label trial to evaluate safety and tolerance of nebulized Liposomal Amphotericin B (Ambisome) for LMA patients during the induction therapy ,intensification, plus Allogeneic Haematopoietic Progenitor Cell transplant in due course, as well for patients diagnosed of several malignant haematologic diseases and treated with Allogeneic Haematopoietic Progenitor Cell Transplant

Completed10 enrollment criteria

Prophylaxis of Fungal Invasive Infections in Leukemia

Invasive Pulmonary Aspergillosis

To assess the overall clinical yield - in terms of efficacy and safety endpoints of adding caspofungin as prophylaxis of Invasive Pulmonary Aspergillosis in patients undergoing induction treatment for newly diagnosed acute leukemia To investigate the prognostic significance of Ptx3 at diagnosis and during the first chemotherapy cycle with respect to the development of IPA

Completed9 enrollment criteria

Diagnostic Value of MRI for Allergic Broncho-Pulmonary Aspergilloses

Allergic Bronchopulmonary Aspergilloses

The aim of the study is to compare the concordance between chest computerized tomography-scan (CTscan) and Magnetic resonance Imaging (MRI) for the description of the abnormalities seen in Allergic BronchoPulmonary Aspergillosis (ABPA).

Completed7 enrollment criteria

Benralizumab in the Treatment of Patients With Severe Asthma With ABPA

ABPASevere Asthma1 more

Phase IV, open-label study will evaluate effects of Benralizumab in the treatment of severe asthma in patients with allergic bronchopulmonary aspergillosis

Withdrawn26 enrollment criteria

Allergic Bronchopulmonary Aspergillosis Prescreening Study

Allergic Bronchopulmonary AspergillosisAsthma1 more

This prescreening study is being conducted to diagnose ABPA in selected patients with asthma and to increase the potential number of eligible participants for the ongoing Study 601-0018 of PUR1900 in subjects with ABPA. See: NCT05667662. Additionally, this prescreening study may provide information that could assist the conduct of future studies conducted by Pulmatrix.

Not yet recruiting13 enrollment criteria

Incidence of Invasive Pulmonary Aspergillosis in Ventilator-associated Pneumonia

Ventilator Associated PneumoniaPulmonary Aspergillosis Invasive

Mechanically ventilated patients are at risk of developing ventilator-associated pneumonia (VAP). Invasive pulmonary aspergillosis (IPA), the diagnosis of which motivates the implementation of specific treatments, is one of the causes of VAP. The hypothesis of the study is that the incidence of IPA is 12.4%. For each patient presenting with a suspicion of VAP and requiring a bronchoalveolar lavage (BAL), the diagnosis of API will be evaluated by biological examinations performed on blood and BAL. Medical and surgical history as well as clinical and biological data will be collected for 28 days or until discharge from the ICU.

Not yet recruiting9 enrollment criteria

Diagnosis of Invasive Pulmonary Aspergillosis, Specific Testing in Bronchial Secretions Versus Bronchoalveolar...

Invasive Pulmonary Aspergillosis

The aim of this research project is to compare the results of Aspergillus specific test methods Aspergillus Galactomannan Enzyme Immunoassay (GM-EIA), Aspergillus polymerase chain reaction (PCR), Aspergillus Galactomannan Lateral Flow Assay (LFA) from different respiratory tract secretions. The bronchoalveolar lavage (BAL) fluid and bronchial secretions (NBL) are compared in the same examination for each patient.

Not yet recruiting4 enrollment criteria
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