Study of Acid Reflux in Asthma
AsthmaLung Diseases2 moreThe purpose of this study is to determine if subjects with symptomatic asthma who are assigned to treatment with a proton pump inhibitor (PPI) drug such as Nexium have fewer asthma attacks than similar subjects assigned to placebo treatment.
Non-invasive Ways to Evaluate Lung Disease After Treatment With Xolair
Lung DiseaseThe purpose of this study is to study the effects of Xolair using non-invasive techniques from the expired gas of patients with moderate to severe allergic asthma.
Tiotropium / Respimat One-Year Study
Pulmonary DiseaseChronic ObstructiveTo evaluate the long term effects of treatment with two doses of Tiotropium delivered by the Respimat inhaler in patients with COPD.
A Study of UK-369,003 on the Safety and Efficacy in Patients With COPD
Pulmonary DiseaseChronic ObstructiveA randomised, controlled study investigating the effect of UK-369,003 on exercise tolerance in patients with COPD
Effect of Roflumilast on Pulmonary Function and Respiratory Symptoms in Patients With Chronic Obstructive...
Chronic Obstructive Pulmonary DiseaseCOPDThe aim of the study is to compare the effect of roflumilast and placebo on the lung function in patients with COPD.
Study of INS37217 Inhalation Solution in Mild to Moderate Cystic Fibrosis Lung Disease
Cystic FibrosisThe purpose of this study is to assess the safety and effectiveness of multiple dosages of INS37217 compared to placebo over 28 days in subjects with mild to moderate cystic fibrosis (CF) lung disease. Study drug will be administered through a nebulizer (a device that delivers medication as a mist by breathing it in).
Lung Health Study II
Lung DiseasesLung Diseases2 moreTo determine if participants with chronic obstructive pulmonary disease, who were assigned to inhaled corticosteroids had a lower rate of decline in lung function and lower incidence of respiratory morbidity compared to participants assigned to placebo.
Trial of Inspiratory Muscle Rest and Exercise in Chronic Obstructive Lung Disease
Lung DiseasesLung Diseases2 moreTo test the effectiveness of ventilatory muscle rest (VMR) using home negative pressure ventilation (NPV) in improving exercise performance, alleviating dyspnea, and improving the quality of life in patients with severe chronic obstructive lung disease.
National Emphysema Treatment Trial (NETT)
EmphysemaLung Diseases3 moreTo evaluate the long term efficacy, morbidity and mortality associated with medical therapy with lung volume reduction surgery (LVRS) as compared to medical therapy alone and to define patient selection criteria. The trial, conducted in conjunction with a patient registry, is supported by the NHLBI, the Centers for Medicare and Medicaid Services (CMS), and the Agency for Healthcare Research and Quality (AHRQ).
Feasibility of Retinoic Acid Treatment in Emphysema (FORTE)
EmphysemaLung Diseases3 moreTo conduct feasibility studies on the use of retinoids in the treatment of emphysema. Specific objectives are to identify optimal patient populations, retinoids, doses, dosing schedules, routes of administration, and outcome measures preparatory to conducting a larger, controlled, clinical trial on the efficacy of retinoid therapy in the management of emphysema.