
Leukotriene Polymorphisms and Montelukast Response - Ancillary to LoDo Trial
AsthmaLung DiseasesTo elucidate the mechanisms underlying inter-patient variation in response to montelukast, a drug for asthma.

Airway Responses Following Chlorine Gas Exposure
AsthmaLung DiseasesTo determine lung airway responses following chlorine gas exposure.

Air Pollution, Inflammation, and New Onset Asthma
AsthmaLung DiseasesTo examine air pollution, inflammation and new onset asthma in a large cohort of children in southern California.

Optimal Approach for Analysis of Case-Control Genetic Association Studies
Lung DiseasesAsthmaThe purpose of this study is to examine the effectiveness of approaches to correct for the effects of population stratification on case-control genetic association studies.

Cardiovascular Vulnerability to Particulate Exposure
Heart DiseaseLung DiseaseThis project is part of a program project directed toward assessing cardiac effects of particulate and other ambient air pollutants. In this project active elderly adults living in the communities of Boston and Steubenville have attended 12 weekly sessions including approximately 40 minutes of Holter monitoring, blood pressure, and oximetry evaluation before, during, and after outdoor exercise. To investigate the relation of air pollution to cardiac and pulmonary rehabilitation, a second portion of this study involves abstraction of blood pressure and symptom data and downloading of available repeated measures telemetry data in two populations. These populations include: 1) 200 outpatients attending 8 to 36 repeated weekly exercise training sessions in a major hospital cardiac rehabilitation unit.

Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Lung DiseaseThe purpose of this study is to determine whether genetic factors contribute to an individuals risk of developing obstructive lung disease from smoking cigarettes.

Linkage Study in Familial Pulmonary Fibrosis
Pulmonary FibrosisLung Diseases2 moreTo map the gene (or genes) for familial pulmonary fibrosis.

Effects of Chronic Ozone Exposure on Lung Function
Lung DiseasesLung Diseases2 moreTo determine the effects of chronic ozone exposure on lung function in young men and women.

Intervention to Improve Asthma Management/Prevention
AsthmaLung DiseasesTo implement and evaluate a comprehensive asthma education and prevention program in all 54 public elementary schools in the predominantly minority Birmingham, Alabama school system.

Promoting Adherence to TB Regimens in Latino Adolescents
Lung DiseasesTuberculosisTo test a public health model of screening, preventive isoniazid treatment, and adherence counseling plus medical education of primary care clinicians to enhance their skills and attention to TB control. Also, to test a behavioral adherence intervention for Latino adolescents with latent disease and a medical education program designed to enhance primary care (community clinic) practitioners' treatment of active and latent TB infection.