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Active clinical trials for "Purpura, Thrombocytopenic, Idiopathic"

Results 321-330 of 380

An Epidemiological Study of Subjects With Immune Thrombocytopenic Purpura to Evaluate the Relationship...

PurpuraThrombocytopenic2 more

This study involves the collection of blood samples from patients with immune thrombocytopenic purpura (ITP) to evaluate the relationship between platelet counts, blood levels of a hormone called thrombopoietin that controls platelet production by the bone marrow, and blood levels of antibodies against thrombopoietin that could interfere with the action of this hormone. Blood samples will also be stored if separately agreed to by the patient for analysis of genes that might affect platelet production. At a single outpatient clinic visit, patients will have a medical history taken, and blood samples drawn for testing. Results from this study may help further understand the control of platelet production in patients with ITP, and suggest new therapeutic approaches.

Completed6 enrollment criteria

Balance Benefit / Risk of Immunomodulatory Treatments at the Child and Adolescent for Autoimmune...

Immune Thrombocytopenic PurpuraAutoimmune Hemolytic Anemia2 more

In France, a national prospective cohort for monitoring children and adolescents with autoimmune cytopenia OBS'CEREVANCE is in place since 2004. It is coordinated in Bordeaux by the Center's team. Reference Rare Diseases CEREVANCE. It has been validated by the French Data Protection Authority in 2009 (information note and written consent). It had mid 2013 more of 900 patients, and the data collected make it possible to study intentionally to treat the therapeutic management of patients with Chronic Immune-Thrombocytopenic Purpura, from Autoimmune Hemolytic Anemia, or from EVANS syndrome. This study evaluates efficacy and tolerance at 6 months of treatment immunomodulators prescribed in France in real conditions of use, in children and adolescents under the age of 18, for a Chronic Immune-Thrombocytopenic Purpura, an Autoimmune Hemolytic Anemia or a simultaneous EVANS syndrome.

Completed4 enrollment criteria

Initial Hemato-immunological Profile on the Evolution of Immunological Thrombopenic Purpura.

Immune Thrombocytopenic PurpuraAutoimmune Thrombocytopenia1 more

This study aims to determine the hemato-immunological parameters predictive of the evolution of a Immune thrombocytopenic purpura (ITP) towards chronicity, and to identify possible differences between the child and the adult.

Completed9 enrollment criteria

Retrospective Study on Caplacizumab-treated Pediatric Patients With Immune-mediated Thrombocytopenic...

Immune-mediated Thrombocytopenic Purpura

The purpose of this multi-country, retrospective data collection study (chart review) is to describe the effectiveness and safety of caplacizumab in pediatric patients with iTTP.

Completed5 enrollment criteria

Retrospective Analysis of the Safety and Efficacy of Hydroxychloroquine in Immune Thrombocytopenia...

Immune ThrombocytopeniaSystemic Lupus Erythematosus

Retrospective study of the safety and efficacy of hydroxychloroquine among patients with immune Thrombopenia (ITP).

Completed4 enrollment criteria

Nexium Capsules Helicobacter Pylori Specific Clinical Experience Investigation

Gastric UlcerDuodenal Ulcer3 more

The purpose of this study is to confirm the safety profile / factors which impact safety and efficacy in patients given triple therapy for Helicobacter pylori eradication with Nexium + amoxicillin (AMPC) + clarithromycin (CAM), or Nexium + AMPC + metronidazole (MNZ) in usual post-marketing use.

Completed6 enrollment criteria

Effects of Long-term Dosing of AMG 531 on Bone Marrow Morphology

Idiopathic Thrombocytopenic Purpura

This study was conducted in conjunction with the 2 phase 3 studies of AMG 531 (20030105 and 20030212) and an open-label extension study (20030213) and compared pretreatment and posttreatment bone marrow samples for the purpose of studying morphologic changes.

Completed4 enrollment criteria

LENS - Long-term Eltrombopag Observational Study

PurpuraThrombocytopaenic1 more

A long term observational ocular safety study in adults who have received study medication (either active drug or placebo) in a phase II or III clinical study evaluating eltrombopag. The study will follow subjects for 2.5 years following their last ocular assessment on their prior treatment study (regardless of the therapeutic indication) and will describe long-term ocular safety with respect to changes in the lenses over time from all subjects.

Completed8 enrollment criteria

The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune Disorders

PemphigusAuto-immune Thrombocytopenic Purpura3 more

The primary purpose of the study is to describe by a prospective observational study the serious adverse events occurring in patients treated off-label by rituximab for various auto-immune diseases.

Completed8 enrollment criteria

Role of CD11a in Pathogenesis of Primary ITP and Effect of Immunosuppressive Therapy on Its Level...

Idiopathic Thrombocytopenic Purpura

The purpose of this study is to investigate the expression of CD11a on subpopulation of lymphocytes and compared its expression between ITP patients and healthy controls and explores its possible role in the pathogenesis of ITP. this may help in decision to use inhibitors (have been developed to block ICAM-1/LFA-1 interactions,) as a line of treatment for ITP and some of these molecules have reached clinical trials. to study if there is correlation between level of CD11a and severity of bleeding at presentation (estimated by bleeding score defined by British Journal of Haematology 2007 and platelet count) to study effect of immunosuppressive treatment on the level of CD11a by evaluating levels of CD11a after response to treatment.

Completed6 enrollment criteria
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