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Active clinical trials for "Purpura, Thrombocytopenic, Idiopathic"

Results 71-80 of 380

Prospective Evaluation of Diagnosis and Treatment of Patients With Autoimmune Cytopenias Including...

Autoimmune Hemolytic AnemiaImmune Thrombocytopenia4 more

The goal of this observational study is to characterize the diagnostic and therapeutic management of autoimmune cytopenias including autoimmune hemolytic anemia, immune thrombocytopenia, and chronic idiopathic/autoimmune neutropenia. The main aims to answer are: evaluation of traditional and novel diagnostic tools including immunohematology, cytokine essays, bone marrow studies, molecular findings, and fecal microbiome. evaluation of type and sequence of the therapies administered, the response rates, and the adverse events. evaluation of clinical and laboratory (immunologic, molecular, and morphologic) predictors of outcome. evolution of autoimmune cytopenias into myelodysplastic syndromes. a subgroup of patients with myelodysplastic syndromes will be included to evaluate the presence of immunologic events, autoimmune activation, and red cell metabolism. Participants will receive a clinical/laboratory diagnostic workup as per current clinical practice. Furthermore They will be sampled at baseline (peripheral blood and feces for microbiome) and followed up for at least 3 years to evaluate their clinical course, therapeutic management and outcome.

Recruiting7 enrollment criteria

Machine-learning Based Prediction Model in Primary Immune Thrombocytopenia

Immune ThrombocytopeniaITP

This study developed the first prediction model for risk of critical ITP bleeds for ITP inpatients using a novel machine learning algorithm. This model has been implemented as a web-based model so that clinicians can obtain the estimated probability of critical ITP bleeds for ITP inpatients. The objective of this study is to prospectively and externally validate the risk of critical ITP bleeds in newly admitted ITP patients.

Recruiting7 enrollment criteria

ITP Registry and Accompanying Biospecimen Collection

Immune Thrombocytopenia

The objective of this ITP registry is to collect clinical information, including biosampling, from consenting patients with a variety of ITPs at different points in the course of their disease.

Recruiting5 enrollment criteria

IVIg Plus Low Dose rhTPO for ITP in Pregnancy

Immune ThrombocytopeniaPregnancy Related

Randomized, open-label, multicenter study to investigate the efficacy and safety of IVIg plus low-dose recombinant thrombopoietin in pregnant patients with corticosteroid or IVIg monotherapy-resistant ITP.

Not yet recruiting2 enrollment criteria

A Clinical Trial to Assess Safety and Efficacy of Daratumumab in the Treatment of Primary Immune...

Immune Thrombocytopenia

A single-center, open-label, off-label use investigator-initiated clinical study with safety run-in to explore the clinical activity and safety of daratumumab in adult ITP patients who have not responded adequately or relapsed after first-line treatment and at least one second-line therapy including rituximab and/or TPO-RA.

Not yet recruiting16 enrollment criteria

Zanubrutinib and Eltrombopag as Second-line Treatment in Adults With Primary Immune Thrombocytopenia...

Immune Thrombocytopenia

Randomized, open-label, multicenter study to compare the efficacy and safety of zanubrutinib plus eltrombopag compared to eltrombopag monotherapy for the first-line treatment of adults with chronic immune thrombocytopenia (ITP).

Not yet recruiting12 enrollment criteria

COVID-19 Vaccine and Development of Immune Thrombocytopenic Purpura

COVID-19 Vaccine

Detect development of immune thrombocytopenic purpura (ITP) after different types of (COVID-19) vaccination

Recruiting4 enrollment criteria

Atorvastatin in Management of Newly Diagnosed ITP

Immune ThrombocytopeniaPurpura1 more

The project was undertaking by Qilu Hospital of Shandong University in China. In order to report the efficacy and safety of atorvastatin for the treatment of adults with immune thrombocytopenia (ITP).

Not yet recruiting11 enrollment criteria

A Study of Orelabrutinib in Patients With ITP

Immune Thrombocytopenia

This project was undertaken to evaluate the efficacy and safety of BTK inhibitor Orelabrutinib for the secondary treatment of adults with primary immune thrombocytopenia (ITP).

Not yet recruiting10 enrollment criteria

An Observational, Multicenter Study to Evaluate the Use and Effectiveness of Doptelet® in Patients...

Immune ThrombocytopeniaITP

This is a multi-center, observational, Phase 4 study in patients with Immune Thrombocytopenia (ITP) designed to describe the real-world effectiveness of Doptelet and assess the patterns of drug utilization to add to the knowledge base regarding the use of Doptelet in routine medical practice. Patients eligible for participation will, as part of their routine medical care, be receiving Doptelet for the treatment of ITP.

Recruiting11 enrollment criteria
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