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Active clinical trials for "Rectal Neoplasms"

Results 371-380 of 1338

Predicting Neoadjuvant Therapy Response of Rectal Cancer With MRI

Rectal Neoplasms

The purpose of this study is to investigate if MRI scans performed after neoadjuvant radiotherapy can predict the therapeutic response of rectal cancer following preoperative chemo-radiotherapy. This will help doctors to better tailor treatments for rectal cancer in the future.

Active12 enrollment criteria

Advanced Pelvic Surgical Oncology Database - Prospective Observational Study

Rectal CancerPelvic Cancer2 more

Retrospective and prospective observational study of patients undergoing advanced pelvic oncological resection for maligancy including multi visceral resection, beyond TME resection and sacrectomy/flap reconstruction/urinary reconstruction at Glasgow Royal Infirmary. Goal is to study and report outcomes for patients to characterise and understand major complications, natural history of resectional patients and identify areas for future interventional study.

Recruiting2 enrollment criteria

Tempus Priority Study: A Pan-tumor Observational Study

Breast CancerProstate Cancer25 more

Observational study that will be collecting clinical and molecular health information from cancer patients who have received comprehensive genomic profiling and meet the specific eligibility criteria outlined for each cohort with the goal of conducting research to advance cancer care and create a dataset that furthers cancer research.

Recruiting6 enrollment criteria

Changes of Low Anterior Resection Syndrome and Balance Ability in Patients With Rectal Cancer.

Rectal Cancer

The purposes of this study are to explore the trajectory of symptom distress and balance ability in patients with rectal cancer.

Recruiting7 enrollment criteria

Multicenter Cohort Prospective Study on Multidisciplinary Treatment of Rectal Cancer

Metastatic Colorectal Cancer

The purpose of this study is to describe the diagnostic and treatment procedures employed for patients with rectal cancer in each participating center. Outcomes to treatment, costs of treatment will be described. Exploratory analyses will be done to identify factor that influence patient prognosis, as well as factors that predict patient response to treatment.

Recruiting3 enrollment criteria

Prospective Observational Trial to Evaluate Quality of Life After Neoadjuvant Radiation or Chemoradiation...

Rectal CancerQuality of Life2 more

Observational study to evaluate longitudinal quality of life according to standardized EORTC questionaires as well as functional Outcome, oncological outcome and toxicity in patients treated with neoadjuvant short term radiation or long-term chemoradiation followed by surgery

Recruiting9 enrollment criteria

Genetic Testing in Screening Patients With Metastatic or Unresectable Colon or Rectal Cancer for...

Metastatic Colon AdenocarcinomaMetastatic Rectal Adenocarcinoma18 more

This trial screens patients with colon or rectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable) for genetic mutations for recommendation to a molecularly assigned therapy. Identifying gene mutations may help patients enroll onto target companion trials that target these mutations.

Recruiting15 enrollment criteria

A Prospective Feasibility Study Evaluating Extracellular Vesicles Obtained by Liquid Biopsy for...

Rectal CancerLiquid Biopsy

Routine clinical and radiological assessment of response of patients with rectum cancer to neoadjuvant chemoradiotherapy does not allow accurate identification of complete pathological response, and leads to frequent false positive and negative results. Molecular markers reflecting the initial and post-nCRT status of the tumor would be ideal to select patients eligible for organ preservation. This project will test the detection of tumor extracellular vesicles (EVs) in liquid biopsy as a reliable marker for the identification of poor versus good responders to nCRT.

Recruiting31 enrollment criteria

DETECT: Target Volume for Rectal Endoluminal Radiation Boosting

Rectal Cancer

The aim of the study is to provide prospective data regarding microscopic tumor spread in all directions from the macroscopic tumor in pathology specimens, as seen by eye, and on imaging to define the target volume for endoluminal radiation boosting in rectal cancer patients.

Recruiting10 enrollment criteria

Mesorectal Microbiome as a Prognostic Factor in Patients With Rectal Cancer

Rectal Cancer

The equilibrium of intestinal microorganisms is essential for health an imbalance has been associated with an increased risk in the development of different pathologies; including colorectal cancer. Rectal cancer is the third most common neoplasm worldwide and the complete excision of the mesorectum is a major prognostic factor. The identification of microorganisms in the adipose tissue that surrounds the small intestine in inflammatory diseases, together with bacterial alterations found in colonic mucosa and feces in patients with rectal cancer in comparison with healthy individuals indicates that microbiome alteration plays an essential role in pathogenesis. The mesorectal microbiome in rectal cancer patients stills unknown and given its importance in the prognostic of the disease the goal of this study is to identify microbial profiles that allow predicting rectal cancer patients with a poor prognosis.

Recruiting23 enrollment criteria
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