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Active clinical trials for "Multiple Sclerosis, Relapsing-Remitting"

Results 61-70 of 533

Study to Evaluate the Safety and Efficacy of PIPE-307 in Subjects With Relapsing-Remitting Multiple...

Relapsing Remitting Multiple Sclerosis

This is a randomized, double-blind study of PIPE-307 or placebo in subjects with relapsing-remitting multiple sclerosis. Subjects will be randomized into 1 of 3 separate cohorts (1:1:1 randomization ratio, PIPE-307 Dose A:PIPE-307 Dose B: Placebo) for a total duration of approximately 30 weeks.

Not yet recruiting23 enrollment criteria

A Study to Compare Efficacy, Pharmacokinetics, Pharmacodynamics and Safety of CT-P53 and Ocrevus...

Relapsing-remitting Multiple Sclerosis

This is a double-blind, randomized, active-controlled, parallel group, Phase 1/3 study to compare efficacy, PK, PD and overall safety of CT-P53 with Ocrevus in patients with Relapsing-remitting Multiple Sclerosis.

Not yet recruiting10 enrollment criteria

Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis

Multiple Sclerosis (MS)Relapsing-remitting Multiple Sclerosis (RRMS)2 more

This project is to: Quantify differences in axonal integrity and organization in aMS versus naPMS patients. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.

Recruiting10 enrollment criteria

MS-ResearchBiomarkerS

Multiple SclerosisMultiple Sclerosis12 more

This study is being conducted to investigate risk factors for disability progression in Multiple Sclerosis and related disorders (MSRD). The primary goal is to assess whether combining information from visual assessment, blood markers, as well as historical and ongoing longitudinal MRIs of the brain, orbit (the part of the skull where eyes are located), and/or spinal cord can predict changes in quantitative disability measures related to MSRD and neurological disease.

Recruiting11 enrollment criteria

Physical Activity, Sedentary Behaviour and Cardiometabolic Health in Multiple Sclerosis

Multiple SclerosisRelapsing-Remitting

This study evaluates the association between sedentary behaviour, physical activity, and the cardiometabolic health of Multiple Sclerosis via several cardiovascular, metabolic and anthropometric parameters.

Recruiting15 enrollment criteria

Effects of a Combined Supplementation of Conjugated Linoleic Acid (CLA) and Probiotics (Vivomixx®)...

Multiple SclerosisRelapsing-Remitting

The goal of this randomized, double-blind, placebo-controlled multicenter study is to investigate whether the combination of food supplementation with Tonalin® and specific probiotics is a safe and effective add-on to first-line disease modifying treatment (DMT, interferon-beta derivatives as well as glatirameracetate and other glatirameroids) in relapsing remitting MS (RRMS). 100 patients will be randomly assigned in a 1:1 ratio to receive either both food supplements for 48 weeks or to receive placebo in addition to their established first-line disease modifying treatment (DMT). The two randomized groups will be compared concerning the change in volume of T2-weighted hyperintense lesions from baseline to 48 weeks.

Not yet recruiting14 enrollment criteria

Reduced Oligodendrocyte-specific Cytotoxicity and Ofatumumab Treatment

Relapsing Remitting Multiple Sclerosis

In this study the investigators wish to test the hypothesis that the repertoire of solutes secreted by leukocytes isolated from patients with relapsing-remitting forms of Multiple Sclerosis (MS) following 6 months of treatment with Ofatumumab (Kesimpta®) will be less toxic to mouse-derived oligodendrocyte lineage cells, grown in a dish, than solutes secreted by the same leukocyte populations prior to treatment with Ofatumumab.

Recruiting29 enrollment criteria

Examining Effects of Ocrevus on Cognitive Fatigue Using fMRI

Multiple SclerosisRelapsing-Remitting

The purpose of this research study is to investigate the effectiveness of MS Disease modifying medications on cognitive fatigue in persons with relapsing remitting multiple sclerosis (RRMS). Cognitive fatigue is the kind of fatigue that occurs after intense mental concentration as after a session of problem solving.

Recruiting10 enrollment criteria

Investigation of Subclinical Markers of Multiple Sclerosis

Multiple SclerosisRelapsing Remitting Multiple Sclerosis

Transcranial magnetic stimulation (TMS) studies reported consistent and substantial impairments in the central nervous system (CNS) in multiple sclerosis (MS). Studies of peripheral nervous system (PNS) function comprising electromyoneurography (EMNG) reported impairments of the PNS in MS that were less pronounced and inconsistent. Neurophysiological studies are generally small and cross-sectional and with the poor grouping of MS patients according to MS type. The objective of the study is to investigate clinical, neurophysiological, and immunological markers in relapsing-remitting MS patients, and in patients with relapsing-remitting MS treated with immunomodulation. The results of the study may contribute to a better understanding of the pathophysiology of multiple sclerosis and can provide guidance in the diagnosis and treatment of patients with relapsing-remitting MS.

Recruiting5 enrollment criteria

A Study Investigating the Utilization, Effectiveness and Quality of Life in Clinical Practice in...

Multiple SclerosisRelapsing-Remitting

The purpose of this study is to collect real-world data and to gain insights about long-term usage of ozanimod (Zeposia ®), its effect on well-defined outcome parameters comprising participant-relevant outcomes, as well as quality of life, effectiveness, and incidence of adverse events.

Recruiting7 enrollment criteria
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