Zainidip in Renal Artery Stenosis
HypertensionTo evaluate the efficacy of renal artery stent combined with standardized medical therapy as treatment for renal artery stenosis.
Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions
AtherosclerosisCardiovascular Diseases3 moreThis study will compare medical therapy plus stenting of hemodynamically significant renal artery stenoses versus medical therapy alone in patients with systolic hypertension and renal artery stenosis.
Formula PTX Renal Stent Clinical Study
Renal Artery StenosisThe purpose of the study is to evaluate the safety and effectiveness of the PTX-coating on the Formula PTX Balloon-Expandable Stent in treatment of renal artery stenosis.
REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent...
Renal Artery StenosisThe purpose of the study is to evaluate the safety and effectiveness of the Formula Balloon-Expandable Stent in treatment of renal artery stenosis.
Stenting in Renal Dysfunction Caused by Atherosclerotic Renal Artery Stenosis
Renal Artery ObstructionKidney FailureBackground: Atherosclerotic renal artery stenosis (ARAS) is associated with progressive loss of renal function and is one of the most important causes of renal failure in the elderly. Current treatment includes restoration of the renal arterial lumen by endovascular stent placement. However, this treatment only affects damage caused by ARAS due to the stenosis and ensuing post-stenotic ischemia. ARAS patients have severe general vascular disease. Atherosclerosis and hypertension can also damage the kidney parenchyma causing renal failure. Medical treatment focuses on the latter. Lipidlowering drugs (statins) could reduce renal failure progression and could reduce the overall high cardiovascular risk. The additional effect on preserving renal function of stent placement as compared to medical therapy alone is unknown. Therefore, the STAR-study aims to compare the effects of renal artery stent placement together with medication vs. medication alone on renal function in ARAS patients. Method: Patients with an ARAS of ≥50% and renal failure (creatinine (Cr) clearance <80 mL/min/1.73 m2) are randomly assigned to stent placement with medication or to medication alone. Medication consists of statins, anti-hypertensive drugs and antiplatelet therapy. Patients are followed for 2 yrs with extended follow-up to 5 yrs. The primary outcome of this study is a reduction in Cr clearance >20% compared to baseline. This trial will include 140 patients.
Renal Fractional Flow Reserve in Renal Artery Stenting
Renal Artery StenosisHypertensionThe purpose of the study is to determine potential utility of renal fractional flow reserve in prognosis predicting after renal stent implantation.
Comparison of Best Medical Treatment Versus Best Medical Treatment Plus Renal Artery Stenting
Renal Artery StenosisThe clinical investigation is a prospective, international, multi-centre, randomized (1:1) trial with follow ups at 2, 6, 12 months and 3 years. The purpose of the study is to evaluate the clinical impact of percutaneous transluminal renal artery stenting (PTRAS) on the impaired renal function measured by the estimated Glomerular Filtration Rate (eGFR) in patients with hemodynamically significant atherosclerotic renal artery stenosis (ARAS).
Effects of Intravenous Bendavia™ on Reperfusion Injury in Patients Undergoing Angioplasty of the...
Renal Artery ObstructionHypertension2 moreThis was a Phase 2a prospective, single center, randomized, double-blind, placebo-controlled study designed to assess the efficacy, pharmacokinetics, safety and tolerability of IV elamipretide for reduction of reperfusion injury in subjects with Atherosclerotic Renal Artery Stenosis (ARAS), who are undergoing percutaneous transluminal angioplasty of the renal artery (PTRA).
Ultrasound Wave Therapy for Post-stenotic Microvascular Remodeling
Renal Artery StenosisResearchers are evaluating a noninvasive treatment with ultrasound waves for Atherosclerotic Renal Artery Stenosis (ARAS).
Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease
Chronic Kidney DiseasePulmonary Embolism2 moreThe purpose of this study is to show that the use of low volume iso-osmolar non-ionic radio contrast medium (30 cc) in a thoracic CT Scanning procedure in a selected group of patients with chronic kidney disease (CKD) will avoid contrast induced nephropathy (CIN) in comparison to a similar group of patients with CKD who receive no contrast medium..