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Active clinical trials for "Renal Artery Obstruction"

Results 21-30 of 55

Zainidip in Renal Artery Stenosis

Hypertension

To evaluate the efficacy of renal artery stent combined with standardized medical therapy as treatment for renal artery stenosis.

Completed12 enrollment criteria

Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions

AtherosclerosisCardiovascular Diseases3 more

This study will compare medical therapy plus stenting of hemodynamically significant renal artery stenoses versus medical therapy alone in patients with systolic hypertension and renal artery stenosis.

Completed33 enrollment criteria

Formula PTX Renal Stent Clinical Study

Renal Artery Stenosis

The purpose of the study is to evaluate the safety and effectiveness of the PTX-coating on the Formula PTX Balloon-Expandable Stent in treatment of renal artery stenosis.

Completed5 enrollment criteria

REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent...

Renal Artery Stenosis

The purpose of the study is to evaluate the safety and effectiveness of the Formula Balloon-Expandable Stent in treatment of renal artery stenosis.

Completed8 enrollment criteria

Stenting in Renal Dysfunction Caused by Atherosclerotic Renal Artery Stenosis

Renal Artery ObstructionKidney Failure

Background: Atherosclerotic renal artery stenosis (ARAS) is associated with progressive loss of renal function and is one of the most important causes of renal failure in the elderly. Current treatment includes restoration of the renal arterial lumen by endovascular stent placement. However, this treatment only affects damage caused by ARAS due to the stenosis and ensuing post-stenotic ischemia. ARAS patients have severe general vascular disease. Atherosclerosis and hypertension can also damage the kidney parenchyma causing renal failure. Medical treatment focuses on the latter. Lipidlowering drugs (statins) could reduce renal failure progression and could reduce the overall high cardiovascular risk. The additional effect on preserving renal function of stent placement as compared to medical therapy alone is unknown. Therefore, the STAR-study aims to compare the effects of renal artery stent placement together with medication vs. medication alone on renal function in ARAS patients. Method: Patients with an ARAS of ≥50% and renal failure (creatinine (Cr) clearance <80 mL/min/1.73 m2) are randomly assigned to stent placement with medication or to medication alone. Medication consists of statins, anti-hypertensive drugs and antiplatelet therapy. Patients are followed for 2 yrs with extended follow-up to 5 yrs. The primary outcome of this study is a reduction in Cr clearance >20% compared to baseline. This trial will include 140 patients.

Completed13 enrollment criteria

Renal Fractional Flow Reserve in Renal Artery Stenting

Renal Artery StenosisHypertension

The purpose of the study is to determine potential utility of renal fractional flow reserve in prognosis predicting after renal stent implantation.

Completed12 enrollment criteria

Comparison of Best Medical Treatment Versus Best Medical Treatment Plus Renal Artery Stenting

Renal Artery Stenosis

The clinical investigation is a prospective, international, multi-centre, randomized (1:1) trial with follow ups at 2, 6, 12 months and 3 years. The purpose of the study is to evaluate the clinical impact of percutaneous transluminal renal artery stenting (PTRAS) on the impaired renal function measured by the estimated Glomerular Filtration Rate (eGFR) in patients with hemodynamically significant atherosclerotic renal artery stenosis (ARAS).

Completed38 enrollment criteria

Effects of Intravenous Bendavia™ on Reperfusion Injury in Patients Undergoing Angioplasty of the...

Renal Artery ObstructionHypertension2 more

This was a Phase 2a prospective, single center, randomized, double-blind, placebo-controlled study designed to assess the efficacy, pharmacokinetics, safety and tolerability of IV elamipretide for reduction of reperfusion injury in subjects with Atherosclerotic Renal Artery Stenosis (ARAS), who are undergoing percutaneous transluminal angioplasty of the renal artery (PTRA).

Terminated21 enrollment criteria

Ultrasound Wave Therapy for Post-stenotic Microvascular Remodeling

Renal Artery Stenosis

Researchers are evaluating a noninvasive treatment with ultrasound waves for Atherosclerotic Renal Artery Stenosis (ARAS).

Withdrawn21 enrollment criteria

Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease

Chronic Kidney DiseasePulmonary Embolism2 more

The purpose of this study is to show that the use of low volume iso-osmolar non-ionic radio contrast medium (30 cc) in a thoracic CT Scanning procedure in a selected group of patients with chronic kidney disease (CKD) will avoid contrast induced nephropathy (CIN) in comparison to a similar group of patients with CKD who receive no contrast medium..

Completed11 enrollment criteria
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