search

Active clinical trials for "Acute Kidney Injury"

Results 251-260 of 1194

Early Deresuscitation Strategy Driven by Tissue Perfusion in Renal Replacement Therapy in Patients...

Acute Kidney InjuryFluid Overload

In Intensive Care Unit (ICU) patients with acute kidney injury (AKI) and treated with renal replacement therapy (RRT) often present a fluid overload which is associated with morbidity (mechanical ventilation duration increase, kidney recovery decrease) and mortality. Patients' prognostic could be improved by correcting the fluid overload with net ultrafiltration (UFnet) however it may lead to harmful iatrogenic hypovolemia responsible of deleterious ischemic lesions. In usual practice, UF net prescription are variable and there are different international recommendations. Some observational studies suggest that using a UFnet between 1 et 1.75 mL/kg/h in fluid overloaded patient decrease mortality. Fluid overload increases morbidity and mortality, particularly in RRT. Studies without RRT argue for an efficacy of management by decreasing the fluid overload .Cohort studies suggest to use a moderate UFnet instead of a low UFnet. Some data from studies on early versus late RRT that relate the fluid balance or correct the fluid overload during the early strategy argue for a beneficial effect of an early deresuscitation strategy Consequently, the impact of a moderate UFnet (to decrease the fluid overload) compared to a low UFnet (to stabilize the fluid overload) in a randomized interventional study could be assessed. The study hypothesis is that : an early fluid overload deresuscitation protocol with a high UFnet (2 ml/kg/h) targeting both the negativation of cumulated fluid balance to reach a dry weight and the maintenance of tissue perfusion. Compared to fluid overload deresuscitation protocol with a low UFnet (between 0 and 1 ml/kg/h) to reach a stabilization of cumulated fluid balance without monitoring the tissue perfusion. could improve overall, renal, hemodynamic and respiratory prognosis in fluid overloaded patients with renal replacement therapy in ICU

Not yet recruiting17 enrollment criteria

Telemedicine Notifications With Machine Learning for Postoperative Care

Surgery--ComplicationsPerioperative/Postoperative Complications2 more

The ODIN-Report study will be a randomized controlled trial of the effect of providing machine learning risk forecasts to providers caring for patients immediately after surgery on serious complications. The complications studied will be ICU admission or death on wards, acute kidney injury, and hospital length of stay.

Not yet recruiting7 enrollment criteria

UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events...

Acute Kidney Injury

Nearly one in ten people who are hospitalized in Canada develop a complication with sudden loss of kidney function, called acute kidney injury (AKI). AKI may lead to other severe health problems after discharge home, such as kidney failure requiring dialysis treatment, heart failure, heart attacks, stroke, and even premature death. Discharge from hospital to home can be a difficult transition where there are often gaps in identification, communication, care coordination, education, and planning of care for AKI. The study team will co-design and evaluate a tailored post-discharge care plan that is based on the risk of later kidney problems and uses currently available, yet untapped digital innovation to improve the health and experience of people with AKI. This study will be built into Alberta's new provincial electronic health record (EHR). The plan is to use digital tools in the EHR to identify all people in Alberta hospitals that have had an AKI event and are at increased risk of long-term complications. Half will randomly be assigned to receive a tailored care plan based on their risk at hospital discharge while the other half will receive care as it is currently provided by their healthcare team. The electronic health system will automatically calculate a patient's risk and report this risk in their chart along with recommendations for care. The study team includes patients, healthcare providers, and health system decision makers needed to co-develop the proposed strategy and introduce the changes needed to deliver this intervention. The investigators will study whether this strategy can reduce health problems that may happen after AKI including death, need for dialysis, heart attacks, and stroke. The investigators will also determine if the approach improves patient experience during the transition from hospital to home. This study has the potential to revolutionize how we care for people that leave hospital after having AKI.

Not yet recruiting10 enrollment criteria

Hemodynamic Effects of Blood Flow Variation in Continuous Renal Replacement Therapy

Acute Kidney InjuryEnd-stage Renal Disease

Purpose of this study is to evaluate the short-term hemodynamic effects of changes in blood flow rates in critically ill patients receiving continuous renal replacement therapy.

Terminated20 enrollment criteria

Melatonin for Renal Protection in Patients Receiving Polymyxin B

Acute Kidney InjuryMelatonin1 more

This study has the objective to evaluate the effect in renal function of 30mg of Melatonin versus placebo in patients ≥18 years old treated with polymyxin B. The development of nephrotoxicity will be evaluated by RIFLE(Risk, Injury, Failure, Loss, End stage renal disease) score and KIM-1 urinary biomarker for the first 14 days of polymyxin B therapy.

Terminated11 enrollment criteria

Safety & Efficacy of BCT197 in Patients Undergoing Cardiac Surgery

Acute Kidney Injury

This study will assess the safety and efficacy of BCT197 on acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass.

Terminated11 enrollment criteria

Study to Evaluate the Safety and Efficacy of the Renal Assist Device in Patients With Acute Renal...

Kidney FailureAcute

The purpose of this study is to evaluate the safety and efficacy of the RAD to determine whether the RAD is effective in reducing mortality in patients with Acute Renal Failure due to Acute Tubule Necrosis and to evaluate the safety of the RAD If the RAD works normally when used for as long as 72 hours If the RAD will provide added benefits to normal CVVH therapy for patients with Acute Renal Failure

Terminated6 enrollment criteria

Acetylcysteine Against Acute Renal Insult During Cardiopulmonary Bypass.

Cardiovascular DiseaseRenal Insufficiency2 more

The purpose of this study is to determine whether N-acetylcysteine is effective in the prophylaxis of post-cardiopulmonary bypass acute renal impairment.

Suspended6 enrollment criteria

Predictive Value of Renal Venous Flow Profiles for Acute Kidney Injury After Cardiac Surgery

Acute Kidney InjuryCardiorenal Syndrome

The prospective single-center study investigates whether preoperative Doppler-based renal venous flow profiles predict risk of acute kidney injury after cardiac surgery.

Active9 enrollment criteria

Development of a Web-based Multicenter Registry on the Use of oXiris Membrane for EBPTs in Critically...

Critical IllnessAcute Kidney Injury2 more

The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting. Nonetheless, most of the clinical trials aimed at exploring the effect of EBPT on patients' long-term outcomes have failed to demonstrate consistent results regarding 28 day- or hospital- mortality rates. The aim of this observational prospective registry is to evaluate if there is a cluster of critically ill patients that mostly benefits from extracorporeal blood purification therapies with oXiris membrane.

Active3 enrollment criteria
1...252627...120

Need Help? Contact our team!


We'll reach out to this number within 24 hrs