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Active clinical trials for "Respiratory Distress Syndrome, Newborn"

Results 431-440 of 1218

Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute...

Septic ShockSevere Sepsis2 more

Severe sepsis/septic shock is a serious condition associated with high mortality rate. Hydrocortisone has been recommended as a useful treatment to decrease mortality in hemodynamically unstable septic shock patients, not response to fluid and moderate dose of vasopressor. During the progression of severe sepsis/septic shock, multi-organ dysfunction can develop. Acute lung injury (ALI) and its more severe form, acute respiratory syndrome (ARDS) is one of the common organ dysfunction associated with septic shock. Information from a meta-analysis suggested that moderate dose of hydrocortisone may improve the ARDS patients' outcome. Whether hydrocortisone can effectively prevent disease progression and death in severe sepsis/septic shock patients who complicated with ALI/ARDS has not been proven.

Completed9 enrollment criteria

Human Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (START)

Respiratory Distress SyndromeAdult

This was a Phase 2a, randomized, double-blind, placebo-controlled, multi-center trial to assess the safety and efficacy of a single dose of Allogeneic Bone Marrow-derived Human Mesenchymal Stromal Cells (hMSCs) infusion in patients with Acute Respiratory Distress Syndrome (ARDS).

Completed23 enrollment criteria

Treprostinil Sodium Inhalation for Patients At High Risk for ARDS

Respiratory Distress SyndromeAdult

Acute Respiratory Distress Syndrome (ARDS) is a rapidly progressing lung disease caused by a number of factors including pneumonia, sepsis and acute trauma that leads to reduced lung function and breathlessness. There are no pharmacological treatments approved for the treatment of ARDS. This pilot trial will study the safety and efficacy of Treprostinil sodium by inhalation for preventing the progression of acute hypoxemic respiratory failure to positive pressure ventilation and/or ARDS in patients at high risk.

Terminated21 enrollment criteria

Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress...

Acute Respiratory Distress Syndrome (ARDS)Multiple Organ Failure

Acute respiratory distress syndrome (ARDS) in combination with multi-organ dysfunction syndrome (MODS) is a life-threatening condition, particularly when treatment modalities such as extracorporeal membrane oxygenation (ECMO) and catecholamine administration have failed to treat the severe condition. In this study, the investigators report patients who responded to intrapleural steroid instillation (IPSI) while being unresponsive to conventional treatment (use of intravenous steroids, nitric oxide inhalation, high-frequency oscillatory ventilation, or ECMO) for treatment of critical illnesses such as ARDS in combination with MODS.

Completed17 enrollment criteria

Safety Study of Feeding With Ginger Extract in Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome

An enteral diet supplemented with ginger extract in acute respiratory distress syndrome (ARDS) patients may be beneficial for gas exchange and could decrease duration of mechanical ventilation and length of stay in intensive care unit (ICU).

Completed17 enrollment criteria

Surfactant Application During Spontaneous Breathing With Continuous Positive Airway Pressure (CPAP)...

Respiratory Distress SyndromeNewborn

This study investigates the efficacy of surfactant application during spontaneous breathing with CPAP in avoiding death and chronic lung disease (CLD) in very immature infants with a gestational age of less than 27 weeks.

Completed7 enrollment criteria

Non-Invasive Positive Pressure Ventilation and Adult Respiratory Distress Syndrome (ARDS)

Acute Respiratory Distress Syndrome

Background and objective: To determine the efficacy of non-invasive positive pressure ventilation (NPPV) and its effects upon intubation rate and mortality in ARDS.

Completed7 enrollment criteria

ARDSnet Protocol vs. Open Lung Approach in ARDS

Respiratory Distress SyndromeAdult

Many patients with Acute Respiratory Distress Syndrome or ARDS need breathing support that is provided by a machine called a ventilator or respirator. The purpose of this study is to find out if a new method of setting the ventilator for patients with severe ARDS is better than the standard, commonly used way of setting the ventilator.

Completed23 enrollment criteria

Protective Ventilation With Carbon Dioxide (CO2) -Removal Technique in Patients With Adult Respiratory...

Adult Respiratory Distress Syndrome

30% of ARDS patients ventilated according to NIH protocol presents morphological (CT) and functional (Stress Index>1) conditions of hyperinflation even with Plateau pressure (Pplat) < 30 cmH2O; values of Pplat lower than 26 cmH2O were associated with more a condition of more protective ventilation. In patients at risk of hyperinflation, use of alternative techniques such as CO2-removal my allow the reduction of Tidal Volume (Vt) and Pplat.

Completed13 enrollment criteria

Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study

Infant Respiratory Distress SyndromeRespiratory Insufficiency1 more

The purpose of this study is to test whether application of high frequency ventilation through a nasal tube can lower blood carbon dioxide levels in stable preterm infants.

Completed6 enrollment criteria
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