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Active clinical trials for "Respiratory Distress Syndrome, Newborn"

Results 1071-1080 of 1218

Cross-section Survey of Mechanical Ventilation and Acute Respiratory Distress Syndrome in China...

Respiratory FailureAcute Respiratory Distress Syndrome

The characteristics and outcomes of a mixed group of critically ill patients who received mechanical ventilation are not known in China. A 1 month Cross-section survey will be performed with the aim of describing the characteristics and outcomes of conventional mechanical ventilation and treatment of acute respiratory distress syndrome in intensive care units in China.

Completed5 enrollment criteria

Fetal Pulmonary Artery Acceleration to Ejection Time Ratio (PATET) in the Prediction of Subsequent...

RDS

Fetal PATET ratio evaluation to predict neonatal RDS

Completed5 enrollment criteria

SLI MANEUVER and RESPIRATORY MORBIDITIES

Respiratory Distress Syndrome

Purpose: The investigators hypothesis is that, as compared to the only nCPAP-applied group, application of SLI maneuver followed by respiratory support with nCPAP immediately afterwards in preterm infants at high risk for RDS would reduce the need for intubation and mechanical ventilation in early period and ultimately will improve respiratory outcomes.

Unknown status4 enrollment criteria

Assessment of Lung Recruitablity of Acute Respiratory Distress Syndrome With SARS-CoV-2 Pneumonia...

Critical IllnessARDS

Novel coronavirus (SARS-CoV-2: severe acute respiratory coronavirus 2) pneumonia often develop the acute respiratory distress syndrome (ARDS). Lung protective ventilation strategy consisting of low tidal volume and high positive end-expiratory pressure (PEEP) is recommended. However, it is not clear whether injured lungs from SARS-CoV-2 pneumonia have the same mechanical properties, especially response to PEEP as common ARDS. Therefore, the investigators propose an observational study to analyze respiratory mechanics and lung recruitablity using EIT (electrical impedance tomography) in patients with ARDS due to SARS-CoV-2 pneumonia.

Completed13 enrollment criteria

Prospective Electroencephalography Evaluation of Sedation in COVID-19

Conscious SedationPathologic Processes3 more

Sedation of severe COVID-19 disease are often complicated. We try to find a correlate for this observation by encephalographic studies.

Completed2 enrollment criteria

Flow-controlled Ventilation (FCV) in Moderate Acute Respiratory Distress Syndrome (ARDS) Due to...

COVID-19 Acute Respiratory Distress SyndromeRespiration1 more

Flow controlled ventilation (FCV) is a fairly new mode of mechanical ventilation, consisting of a constant inspiratory and expiratory flow. Inspiration is thus comparable to volume controlled ventilation (VCV). The actively controlled, constant flow during expiration is unique. FCV is known to minimize dissipated energy to the lung [ref] and is therefore supposed to aid in lung protective ventilation. The VICAR study is designed as a prospective single cohort crossover trial. The intervention consists of a sequence of respiratory modes: baseline pressure controlled ventilation (PCV) during 5 minutes, followed by 30 minutes of FCV with an evone respirator (Ventinova Medical B.V., Eindhoven, The Netherlands) and eventually 30 minutes of VCV. Every participant will receive the intervention. Respiratory rate (RR), positive end-expiratory pressure (PEEP) and inspiratory fraction of oxygen (FiO2) will be held constant. According to the manufacturers guidelines, an I:E ratio of 1:1 will be pursued during FCV. During FCV, the respirator will be set with the same PIP as during baseline PCV. For VCV, the same tidal volume as during baseline PCV will be set.

Completed8 enrollment criteria

SOLIRIS® (Eculizumab) Treatment of Participants With COVID-19

COVID-19Pneumonia2 more

This protocol provides access to eculizumab treatment for participants with severe COVID-19.

No longer available8 enrollment criteria

Place of ECMO in the Management of Severe Refractory ARDS Associated With Covid-19

Respiratory Distress Syndrome

Describe COVID-19 patients who are receiving ECMO-VV respiratory replacement and what happens to them.

Completed7 enrollment criteria

Comparison of Esophageal and Central Venous Pressure for Estimating Transpulmonary Pressure Changes...

Mechanical VentilationAcute Respiratory Distress Syndrome

Central venous pressure (CVP) is characterized by a low-frequency pleural-dependent as well as a high-frequency cardiac pulsatile component. The aim of the study is to compare the low-frequency component of CVP with the esophageal pressure (Pes), as surrogate of pleural pressure, to estimate trans-pulmonary pressure (PL).

Completed12 enrollment criteria

Comparison of Non-invasive Oxygenation Strategies in Patients Admitted for Covid-19 Acute Respiratory...

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Acute Respiratory Distress Syndrome (ARDS) is the main clinical presentation of SARS-CoV-2 (Covid-19) infected patients admitted in Intensive Care Unit (ICU). During the first phase of the outbreak (between February and May 2020), the use of invasive Mechanical Ventilation (MV) was largely required with 63% of ICU patients intubated in the first 24 hours after admission and up to 80% of patients during the overall ICU stay. Mortality was especially higher when using MV in the first 24 hours. In contrast, the use of non-invasive oxygenation strategies in the first 24 hours was only 19% for High Flow Nasal Cannula oxygen therapy (HFNC) and 6% for Non-Invasive Ventilation (NIV). Several non-invasive oxygenation strategies were proposed in order to delay or avoid MV in ICU patients suffering from Covid-19 ARDS. The use of HFNC became the recommended oxygenation strategy, based in particular on publications prior to the outbreak. The use of NIV or Continuous Positive Airway Pressure (CPAP) combined with HFNC have also been proposed. Although these non-invasive oxygenation strategies seem widely used in the second phase of the outbreak, they have not yet confirmed their clinical impact on MV requirement and patient's outcome. Moreover, no comparison has been made between these different non-invasive oxygenation strategies. The aim of this study is to compare different non-invasive oxygenation strategies (HFNC, NIV, CPAP) on MV requirement and outcome in ICU patients treated for ARDS related to Covid-19.

Completed5 enrollment criteria
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