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Active clinical trials for "Restless Legs Syndrome"

Results 51-60 of 211

Effects of Neupro on Cardiovascular Observations in Patients With Restless Legs Syndrome

Restless Legs Syndrome

Periodic Limb Movements (PLMs) during sleep in patients with Restless Legs Syndrome (RLS) have been shown to be associated with elevations in Blood Pressure (BP). Rotigotine has been shown to effectively reduce the incidence of PLMs in patients with RLS. The current study aims to demonstrate that treatment with Rotigotine could help reduce the number of nocturnal BP elevations associated with PLMs in patients with RLS.

Completed34 enrollment criteria

Pramipexole (BI-Sifrol®) Orally Once Daily for 6 Weeks in Patients With Primary Restless Legs Syndrome...

Restless Legs Syndrome

The objective of this trial is to investigate the efficacy and safety of pramipexole (0.125-0.75 mg) orally once daily as compared with placebo for 6 weeks in patients with primary restless legs syndrome (RLS) and to investigate the reliability of the Japanese version of the RLS rating scale by the International Restless Legs Syndrome Study Group (IRLSSG) as a sub-study.

Completed20 enrollment criteria

Ropinirole Tablets In Young Patients With Restless Legs Syndrome

Restless Legs Syndrome

This is a two-period dose rising study of Ropinirole Immediate Release in adolescent patients with restless legs syndrome (RLS) in order to determine the starting dose for the ropinirole titration regimen for this age group. Patients will receive two single doses unless poor tolerability is observed following the first dose.

Completed2 enrollment criteria

RCT for Pregabalin in Restless Legs Syndrome in South Korea

Restless Legs Syndrome

This randomized, double-blind, placebo-controlled, multicenter clinical trial is designed to to assess the treatment efficacy and tolerability of pregabalin in patients with idiopathic restless legs syndrome in South Korea.

Completed11 enrollment criteria

Switching From Oral Dopamine Agonists to Rotigotine

Restless Legs SyndromeEkbom Syndrome1 more

The primary objective is to demonstrate safety and tolerability of switching patients with Restless Legs Syndrome (RLS) from an oral dopamine agonist to rotigotine. As a secondary objective, the investigators will evaluate control of RLS symptoms on rotigotine compared to the prior oral regimen.

Completed40 enrollment criteria

Dose-Response and Pharmacokinetics of Gabapentin Enacarbil (GEn [XP13512 / GSK1838262]) in Restless...

Restless Legs Syndrome

The objective of the study was to generate the data necessary to determine the gabapentin exposure produced by 4 dose levels of GEn (600 mg, 1200 mg, 1800 mg, and 2400 mg) or placebo, and the corresponding relief of symptoms in subjects with Restless Legs Syndrome (RLS).

Completed15 enrollment criteria

Study of Vitamin C, Vitamin E and Their Combination to Treat Restless Legs Syndrome in Hemodialysis...

Restless Legs SyndromeKidney Failure1 more

The purpose of this study is to determine whether vitamin C, vitamin E and their combination are effective in the treatment of RLS in hemodialysis patients.

Completed4 enrollment criteria

Study to Assess the Effect of Gabapentin Enacarbil on Simulated Driving in Healthy Subjects

Restless Legs Syndrome (RLS)

This is a double-blind, placebo-and active-controlled 3-period crossover study designed to assess the effect of GEn 600 mg on simulated driving performance in healthy volunteers.

Completed35 enrollment criteria

A Sleep Laboratory Study to Investigate the Safety and Efficacy of the Rotigotine Skin Patch in...

Restless Legs SyndromeEnd-Stage Renal Disease

This is a sleep laboratory study to evaluate the efficacy and safety of Rotigotine in subjects with Restless Legs Syndrome and End-Stage Renal Disease requiring hemodialysis. The objectives are to demonstrate superiority of Rotigotine against Placebo as well as to investigate the effect of Rotigotine on quality of life and sleep.

Completed24 enrollment criteria

Probiotics in the Treatment of Iron Deficiency in Children With Restless Leg Syndrome

Iron DeficiencyRestless Leg Syndrome

A double-blind randomized controlled trial comparing iron plus vitamin C plus probiotic (lactobacillus plantarum 299) to iron plus vitamin C plus placebo in correcting the iron deficiency in children with Restless leg syndrome (RLS) and iron deficiency. One hundred children with diagnosis of RLS will be recruited over a two- year period.

Completed10 enrollment criteria
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