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Active clinical trials for "Retinal Perforations"

Results 21-30 of 128

Inverted Internal Limiting Membrane Flap Technique for Macular Hole Retinal Detachment in Highly...

Macular Hole Retinal Detachment

To evaluate efficacy of vitrectomy with inverted internal limiting membrane (ILM) flap technique for macular hole retinal detachment (MHRD) in highly myopic eyes, and to demonstrate postoperative clinical course of MHRD after inverted ILM flap technique using swept-source optical coherence tomography (OCT)

Completed2 enrollment criteria

Human Amniotic Membrane Plug for Large Macular Holes

Macular Holes

This is a prospective, interventional, consecutive case series conducted in Alexandria university. The aim of the study is to evaluate the therapeutic efficacy of human amniotic membrane in promoting closure of large macular holes.

Completed2 enrollment criteria

Pilot Randomised Controlled Trial of Posturing Following Surgery for Full-thickness Macular Hole...

Full Thickness Macular Hole

This is a pilot randomised controlled trial (RCT) to investigate the effect of postoperative face-down positioning on the outcome of macular hole surgery.

Completed5 enrollment criteria

Full Thickness Macular Hole and Internal Limiting Membrane Peeling Study

Stage 2 or 3 Full Thickness Macular Hole

A macular hole is a fairly common problem in the retina and is an important cause of loss of central vision. The aim of this study is to determine whether, in patients with a stage 2 or 3 full thickness macular hole (FTMH), peeling a very fine, transparent tissue that covers the surface of the retina, called the internal limiting membrane (ILM) during surgery is superior to non-ILM peeling macular hole surgery. The main outcomes are improvement in vision, achievement of macular hole closure, need for re-operation, health related quality of life (HRQOL) and cost effectiveness.

Completed2 enrollment criteria

Internal Limiting Membrane Peeling for Large Macular Holes

Macular Hole

Rational of the study: for macular holes larger than 400 µm the rate of failure is of more than 20%. It is for these eyes that it is necessary to show the benefit of internal limiting membrane (ILM) peeling in term of vision and success rate. In order to test the benefit of this gesture, it is necessary to make a randomized study. Primary objective: To show that the percentage of success (anatomical closing, confirmed by OCT) at third postoperative month is higher in the ILM peeling group. Design of the study: Randomized multicentric study, in parallel groups, with individual benefit for the patient. Tested Hypothesis: The success rate of the surgery of idiopathic macular holes larger than 400 µm is increased by the peeling of the MLI. Awaited results: To show that the success rate of the surgery of idiopathic macular holes larger than 400 µm is improved by ILM peeling. This category could then have a success rate similar to the small holes. If this difference is not proven, it will remain no justification to continue this procedure which represents little risk but which is not either without consequence.

Completed12 enrollment criteria

Effects of Macular Buckle Versus Vitrectomy on Macular Hole and Macular Detachment in Highly Myopic...

Macular HolesHigh Myopia1 more

Full-thickness macular Hole associated with macular detachment is a one of the maculopathies of high myopia. There is controversy in the primary treatment for this situation. This study will compare the effects of macular buckling versus vitrectomy in a cohort of highly myopic eyes with this situation.

Completed8 enrollment criteria

Optical Coherence Tomography Angiography Characteristics of Patients With Surgically Closed Full-thickness...

Macular HolesOptical Coherence Tomography

State of the art treatment for idiopathic macular holes consists of pars plana vitrectomy, internal limiting membrane staining with a blue colouring dye, internal limiting membrane peeling and filling of the vitrectomized space with a specific tamponade such as air and SF6. Air and SF6 have previously shown similar closure rates, although there was a trend towards lower closure rates in large diameter IMH (Idiopathic Macular Holes) using air. IMH with diameters < 600 μm are currently believed to have similar closure rates with air and SF6. The investigators want to assess possible effects of the used tamponade (air or SF6) on closure rates and perfusion parameters represented by OCTA (Optical coherence tomography angiography). IMH eyes with a minimum diameter > 600 μm will be excluded. Two idiopathic macular hole patient groups will therefore be formed: The first group (group 1) will receive air after vitrectomy and membrane peeling, the second group (group 2) will receive 10% SF6 (and 90% air) after vitrectomy and membrane peeling. After recruitment, patients will therefore be electronically randomized to one of the two groups. The groups will then be compared by the means of OCT (Optical coherence tomography) and OCTA. Note: The trial was registered retrospectively on Clinicaltrials.gov after start of recruitment.

Completed21 enrollment criteria

Effect of Topical Aqueous Suppressants on Intraocular Gas Duration Following Pars Plana Vitrectomy...

Macular HoleRetinal Detachment

The purpose of this study is to see if glaucoma eye drops (dorzolamide-timolol) have any effect on the duration of an intraocular gas bubble following pars plana vitrectomy.

Completed6 enrollment criteria

Double Flap Technique for Macular Hole

Macular Holes

Double flapping technique to close the macular hole.

Completed3 enrollment criteria

Internal Limiting Membrane Flaps for Coexistent Macular Hole and Retinal Detachment

Retinal Detachment

Purpose: To evaluate the logical surgical approaches in closing macular holes in eyes of proliferative diabetic retinopathy with retinal detachment

Completed2 enrollment criteria
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