Bimodal and Coaxial High Resolution Ophtalmic Imaging
Retinitis PigmentosaMaculopathy10 moreThe knowledge of the pathogenesis of retinal affections, a major cause of blindness, has greatly benefited from recent advances in retinal imaging. However, optical aberrations of the ocular media limit the resolution that can be achieved by current techniques. The use of an adaptive optics system improves the resolution of ophthalmoscopes by several orders of magnitude, allowing the visualization of many retinal microstructures: photoreceptors, vessels, bundles of nerve fibers. Recently, the development of the coupling of the two main imaging techniques, the Adaptive Optics Ophthalmoscope with Optical Coherence Tomography, enables unparalleled three-dimensional in vivo cell-scale imaging, while remaining comfortable for the patients. The purpose of this project is to evaluate the performance of this system for imaging micrometric retinal structures.
Environmental Localization Mapping and Guidance for Visual Prosthesis Users
Retinitis PigmentosaVisual Impairment1 moreThis study is driven by the hypothesis that navigation for users of retinal prosthetics can be greatly improved by incorporating Spatial Localization and Mapping (SLAM) and object recognition technology conveying environmental information via a retinal prosthesis and auditory feedback. The investigators will study how effectively the SLAM technology enables the visual prosthesis system to construct a map of the user's environment and locate the user within that map. The technology will be tested both with normally sighted individuals donning a virtual reality headset and with retinal prosthesis users (Argus II).
Dose Escalation Study to Evaluate the Safety/Tolerability and Efficacy of EA-2353 in Subjects With...
Retinitis PigmentosaRetinitis Pigmentosa SyndromeThis is an open-label, multiple ascending dose study to evaluate the safety, tolerability, and efficacy of EA-2353 in subjects with RP. Unilateral intravitreal injections (IVT) will be administered into the subject's Study Eye. There will be up to 4 cohorts.
Interventional Study of Implantation of hESC-derived RPE in Patients With RP Due to Monogenic Mutation...
Retinitis PigmentosaPhase I/II open-label, safety, tolerability and preliminary efficacy study of implantation into one eye of hESC-derived RPE (Human Embryonic Stem Cell Derived Retinal Pigment Epithelium (RPE)) in patients with retinitis pigmentosa due to monogenic mutation. Study non randomized single group assignment consisting in 2 sequential cohorts of patients: First cohort of 2 patients with very advanced loss of visual acuity (legally blind) Second cohort of 10 patients with less advanced loss of visual acuity:
Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With...
X-Linked Retinitis PigmentosaA clinical trial of AAV5-RPGR vector for patients with X-linked retinitis pigmentosa (XLRP)
Study to Evaluate the Efficacy Safety and Tolerability of Ultevursen in Subjects With RP Due to...
Retinitis PigmentosaUsher Syndrome Type 27 moreThe purpose of this study is to evaluate the efficacy safety and tolerability of ultevursen administered via intravitreal injection (IVT) in subjects with Retinitis Pigmentosa (RP) due to mutations in exon 13 of the USH2A gene.
PDE6A Gene Therapy for Retinitis Pigmentosa
Retinitis PigmentosaThe PDE6A gene encodes a subunit of the rod phosphodiesterase. The loss of this enzyme function leads to a chronically elevated cGMP level which causes an increased calcium inflow into the cell and thereby the hyperactivation of cell death pathways. The goal of the PIGMENT study is to develop, produce and investigate a recombinant adeno-associated viral (AAV) gene transfer vector for the curative therapy of PDE6A-linked retinitis pigmentosa in patients, in order to counteract their disease progression and to stop further impairment of visual function. The vector is given with a single subretinal injection.
A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis...
Autosomal Dominant Retinitis PigmentosaEye Diseases7 moreThis study evaluates the safety, tolerability and efficacy of QR-1123 injection in the eye (intravitreal; IVT) injections (one eye/unilateral) in subjects receiving a single dose or repeat doses. Single injections will be assessed in an open label way, and repeat injections will be assessed in a double-masked, randomized, sham-controlled fashion.
Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in...
X-Linked Retinitis PigmentosaA clinical trial of AAV5-RPGR vector for patients with X-linked retinitis pigmentosa (XLRP)
Safety and Tolerability of hRPC in Retinitis Pigmentosa
Retinitis PigmentosahRPC is a cell therapy for retinitis pigmentosa. This is a first-in-human, dose escalation study in which participants with retinitis pigmentosa will receive a single subretinal injection of hRPC cells in one eye to evaluate safety and tolerability. Participants will be followed for two years to evaluate the safety and tolerability of hRPC Additional testing will seek to establish any preliminary efficacy from hRPC.