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Active clinical trials for "Schizophrenia"

Results 2931-2940 of 3086

Seroquel (Quetiapine Fumarate) InPractice Evaluation Programme

Schizophrenia

Patients eligible for entry into the study have a diagnosis of schizophrenia defined by Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) criteria and of a chronic or sub-chronic nature.The primary purpose of the study is to observe symptoms changes over 6 months in schizophrenia in patients treated with Seroquel; additionally disease severity and treatment compliance are followed

Completed3 enrollment criteria

Genes, Intermediate Phenotypes and Response to Quetiapine RX

Schizophrenia

Pharmacological treatment of schizophrenia is still characterized by a certain proportion of patients who are resistant to common antipsychotics. Variability in individual response ranges from patients who experience complete or near complete symptom remission to a subset of patients who remain treatment-refractory despite extensive drug trials over years. The investigators propose to take advantage of the simultaneous acquisition of clinical and of intermediate phenotypes to ascertain the possible contribution of SNPs within putative causative genes to response to treatment with quetiapine XR.

Completed24 enrollment criteria

Schizophrenia Treatment Adherence Investigation (STAI)

SchizophreniaSchizoaffective Disorder

The primary objective of this treatment review and feedback program is to quantify the risk status for medication adherence in a cohort of Australian patients diagnosed with schizophrenia.

Completed6 enrollment criteria

Attention and Visual Perception in Schizophrenia: A Functional Magnetic Resonance Imaging (fMRI)...

Schizophrenia

The main objective of the study is to contribute to a better understanding of the physiopathology of schizophrenia, by studying causal relationships between cognitive deficits and the neurobiological basis for these deficits. Processing visual information involves both automatic grouping processes and control processes. Automatic grouping processes allow the building of a global configuration from local contour information. It is necessary in order to recognize objects. Control processes allow tending to and prioritizing information parts. The paradigm the investigators use allows to dissociate these processes, and is used in order to characterize the impairments observed in patients with schizophrenia. It is adapted to fMRI in order to explore the neurobiological basis of the deficits. The investigators will examine whether functional disconnectivity between activated areas subtend the impairments observed in patients.

Completed10 enrollment criteria

An Observational Study of Olanzapine Coated and Orodispersible Tablets Effectiveness in Schizophrenic...

SchizophreniaBipolar Disorder

The primary objective of this study is to assess the proportion of schizophrenic patients and the proportion of bipolar patients who discontinue olanzapine within 12 months of treatment in outpatient, ambulatory or community settings

Completed7 enrollment criteria

Do Self-Report and Physician Impressions of Adherence to Oral Antipsychotic Medication Agree With...

SchizophreniaSchizoaffective

The purpose of this study is to prospectively examine adherence to oral atypical antipsychotics in patients with schizophrenia. We are psrticularly interested in examining the level of agreement among self-report, physician impressions and objective measures of adherence. We believe that physicians, casemanagers, and clients significantly overestimate the level of adherence.

Completed3 enrollment criteria

A Study to Compare Two Different Brain Imaging Techniques in Healthy Volunteers and in Schizophrenic...

Schizophrenia

A direct comparison of Positron Emission Tomography (PET) (11C-Raclopride) and Single Photon Emission Computed Tomography (SPECT) (123I-IBZM) D2 RO measurements would allow GSK to gain understanding on the SPECT results obtained with SB773812, and to accurately interpret future D2 RO results from either PET or SPECT studies with new compounds.

Completed14 enrollment criteria

Enhancing the Prospective Prediction of Psychosis

SchizophreniaPsychotic Disorders

This study will gather information on the natural history of the basic symptoms of psychosis to identify factors that may affect the improvement or persistence of the symptoms.

Completed4 enrollment criteria

The Role of Personal Identity in Psychotic Symptoms: a Study With the Repertory Grid Technique

SchizophreniaPsychotic Disorders1 more

Personal identity is being recently recognized as a core element for mental health disorders, with relevant clinical implications. However, scarcity of data exists on its role in schizophrenia and related disorders. The repertory grid (RGT), a technique derived from personal construct theory, has been used in different clinical and non-clinical contexts for the study of the construction perception of self and others, to appreciate aspects of interpersonal construing such as polarization and differentiation (unidimensional thinking) or self-construction.and Our study aims to explore the potential influence of the structure of personal identity and of other relevant cognitive factors (social cognition, metacognition, neurocognition) in positive and negative symptoms in people suffering schizophrenia and related disorders.

Completed5 enrollment criteria

Validation of Receptor Occupancy Simulation

Dopamine Receptor OccupancyMedication Satisfaction2 more

To estimate dopamine receptor occupancy by aripiprazole using computer simulation To measure dopamine receptor occupancy by aripiprazole in patients treated with the antipsychotics To validate the simulation result by comparing the receptor occupancy from the simulation with that from the patients

Completed8 enrollment criteria
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