Multi-disciplinary Treatment for Patients Experiencing First Episode of Psychosis
SchizophreniaSchizoaffective Disorder3 moreThis study will assess the effectiveness of an experimental treatment intervention for adolescents and adults who have experienced their first episode of psychosis during the past two years. The DUP sub-study will collect pathways to care information that will be used to inform the development and pilot testing of strategies that aim to reduce DUP among individuals experiencing a first episode of psychosis.
Reducing Internalized Stigma in People With Serious Mental Illness
SchizophreniaSchizoaffective Disorder2 moreThe purpose of this study is to determine if Ending Self-Stigma (ESS), a 9-session group intervention designed to assist veterans with serious mental illness to develop skills (SMI) to effectively cope with stigma and minimize the internalization of stigmatizing beliefs and stereotypes, is more effective in reducing internalized stigma and its associated effects than an active comparison group.
Trial to Evaluate the Effects of OPC-34712 on QT/QTc in Subjects With Schizophrenia or Schizoaffective...
SchizophreniaSchizoaffective DisorderThe purpose of this study is to establish pharmacodynamics (PD), pharmacokinetics (PK), and adverse event (AE) profile of OPC-34712 administered to schizophrenic/schizoaffective subjects. The goals of this trial are three-fold: To determine the effect of OPC-34712 on the individual QT interval (QTcI) corrected for placebo To determine the effect of moxifloxacin on QTcI To examine the concentration-effect relationship of OPC-34712 and moxifloxacin on QTcI
Ginkgo Biloba Extract for Schizophrenia
SchizophreniaA double-blind, randomized, placebo-controlled trial of ginkgo biloba extract (Egb-761) as an add-on therapy to risperidone compared to risperidone plus placebo in the treatment of 200 treatment-naive first-episode patients with schizophrenia. The study addresses an immune dysfunction hypothesis of schizophrenia.
Adjunctive Minocycline in Clozapine Treated Schizophrenia Patients
SchizophreniaSchizophrenia is a devastating and costly illness. One-third to one-half of people with schizophrenia do not respond to the most current drugs leaving clozapine as the best alternative for treatment. However, over 60% of people treated with clozapine continue to have persistent symptoms and cognitive impairments. Little data is available to support evidence-based recommendations to guide clinicians in treating these patients. Preliminary data has suggested that adjunct treatment with minocycline may offer robust symptom improvement in patients with schizophrenia, including those taking clozapine. Minocycline has had interesting effects; including suggesting it may have a significant role in treatment of neurologic and psychiatric disorders. Minocycline is currently available generically; its side effects are well-described and minimal. The proposed double-blind treatment study seeks to demonstrate that adjunctive minocycline offers patients superior efficacy for persistent positive symptoms, cognitive impairments, and/or other components of schizophrenia pathology. This knowledge could lead to the more effective treatment of patients with schizophrenia. The research itself may lead to a better understanding of the pathophysiology of positive symptoms and cognitive impairments, which could contribute to improved treatments in the future.
A Dose-finding Trial of OPC-34712 in Patients With Schizophrenia
SchizophreniaTo investigate the efficacy and safety of OPC-34712 in comparison with placebo in patients with schizophrenia.
A Long-Term Study of JNS007ER in Patients With Schizophrenia
SchizophreniaThe purpose of this study is to assess the safety of JNS007ER 3-12 mg once daily in patients with schizophrenia over a long term period.
Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia
SchizophreniaSchizoaffective Disorder1 moreIn this trial, researchers aim to investigate if prolonged-release melatonin can facilitate the withdrawal of chronic benzodiazepine administration in patients with schizophrenia. Furthermore, researchers will investigate the association of benzodiazepine dose reduction with the following clinically important variables: sleep, psychophysiology, cognition, social function, and quality of life.
Paliperidone ER(Invega®) on Depressive Symptoms of Schizophrenia Patients
SchizophreniaThe purpose of this study is changing (improving), after initiating various doses of Paliperidone ER on schizophrenia patients.
Effectiveness of Ziprasidone for Patients With Schizophrenia
SchizophreniaSchizoaffective DisorderThis study is designed with the aim to evaluate the clinical effect of the overlapped switching to ziprasidone as well as the efficacy and safe metabolic profile of ziprasidone.