Aripiprazole Augmentation for Clozapine-Treated Patients With Refractory Schizophrenia
SchizophreniaThe purpose of this study is to determine whether aripiprazole augmentation is safe and effective in the treatment of clozapine-treated patients with refractory schizophrenia.
Graduated Recovery Intervention Program for Enhancing Treatment for First-Episode Psychosis
Psychotic DisordersSchizophreniaThis study will determine the effectiveness of the Graduated Recovery Intervention Program, a manual-based individual therapy program, in enhancing the clinical benefit of routine treatment for individuals recovering from their first episodes of psychosis.
A Study Comparing Three Strategies to Switch Patients With Schizophrenia or Schizoaffective Disorder...
Schizoaffective DisorderSchizophreniaThe purpose of this study is to compare three strategies for switching patients with schizophrenia or schizoaffective disorder to the atypical antipsychotic, risperdone, after they have been unsuccessfully treated with another atypical antipsychotic, olanzapine. In the second phase of this study, investigators will assess the effectiveness of behavioral therapy in reducing body weight in risperdone-treated patients who are overweight or have problems with diabetes or blood sugar.
Pfizer/IVGTT/Ziprasidone/Olanzapine
SchizophreniaType 2 Diabetes MellitusAbnormalities in peripheral glucose regulation and type 2 diabetes can occur more commonly in individuals with schizophrenia than in healthy subjects or in other psychiatric conditions. Antipsychotic treatment may contribute significantly to abnormalities in glucose regulation. Hyperglycemia can contribute to long-term cardiovascular disease risk that may already be increased in patients with schizophrenia due to higher rates of smoking, sedentary life style, obesity and under-treated hypertension and dyslipidemia. This project will characterize the effects on glucose control of the two most commonly prescribed newer antipsychotic medications, ziprasidone and olanzapine, in patients with schizophrenia.
Immediate Release (IR) to Sustained Release (SR) Switching Study: Study of Switching From IR Seroquel...
SchizophreniaThe purpose of this study is to determine that the efficacy of the sustained release (SR) formulation of quetiapine (Seroquel) is not inferior to the immediate release (IR) formulation. PLEASE NOTE: Seroquel SR and Seroquel XR refer to the same formulation. The SR designation was changed to XR after consultation with FDA.
Abilify Therapy for Reducing Comorbid Substance Abuse
SchizophreniaSchizoaffective Disorder4 moreIt is hypothesized that the use of aripiprazole (Abilify) in patients with alcohol and/or drug dependence with comorbid psychiatric conditions will lead to: Reduction in the amount of alcohol and/or drugs used as measured by the Time Line Follow Back (TLFB) and the Addiction Severity Index (ASI) Reduction in cravings for alcohol and drugs as measured by the Penn Alcohol Craving Scale Reduction in symptoms of co-morbid psychiatric disorders compared to before starting aripiprazole.
Safety And Efficacy Study Of Ziprasidone In Pediatric Psychotic Illness
SchizophreniaAffective Disorders2 moreThe purpose of this research is to determine if Ziprasidone is safe and effective for use in children and adolescents with a psychotic illness, and to determine of Ziprasidone treatment leads to weight changes in children.
Improving Work Outcome in People With Recent-onset Schizophrenia
SchizophreniaThis study will determine the effectiveness of combining antipsychotic medication with Individual Placement and Support (IPS) and group training with the Workplace Fundamentals Module or Brokered Vocational Rehabilitation in facilitating the search for appropriate work or schooling and maintaining work or school activities in people with recent-onset schizophrenia.
Will Decreased Noradrenergic Activity Normalize Information Processing in Patients With Schizophrenia?...
SchizophreniaThe investigators want to try to improve information processing in schizophrenic patients via pharmacological intervention. The hypothesis is that decreased noradrenergic activity will normalize information processing (PPI, P50 gating, P300, and mismatch negativity) in patients with schizophrenia.
Evaluation of Effectiveness of Risperdal® Consta® Compared to Abilify® Over a Two-year Period in...
SchizophreniaPsychotic DisordersThe purpose of this study is to compare the effectiveness of two antipsychotic medications, Risperdal® Consta® versus Abilify®, over a 2-year treatment period in the long-term maintenance of patients with schizophrenia.