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Active clinical trials for "Scleroderma, Diffuse"

Results 471-480 of 491

Role of Macrophage Migratory Inhibitory Factor in Systemic Sclerosis

System; Sclerosis

Migration Inhibitory Factor has proliferative and antiapoptotic actions on fibroblasts which may be relevant to scleroderma because of the central role of a dysregulated fibroproliferative response in disease-affected tissues

Unknown status6 enrollment criteria

Non-Invasive Diagnostic and Functional Evaluation of Cardiac Involvement in Patients With Systemic...

Systemic Sclerosis

The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in systemic sclerosis patients and to establish whether it reflects the severity of RV overload.

Unknown status4 enrollment criteria

Objective Measurement Methods for Autoimmune Disease and Dry Eye Syndrome

Sjögren's SyndromeSystemic Lupus Erythematosus4 more

To explore the association among TCM pattern, TCM tongue diagnosis and TCM pulse diagnosis for Autoimmune disease and Dry eye syndrome

Withdrawn18 enrollment criteria

Stress Echocardiography in the Detection of Pulmonary Arterial Hypertension in Systemic Sclerosis...

SclerodermaSystemic2 more

The purpose of this study is to assess the value in terms of sensitivity, specificity and likelihood ratio of the stress echocardiography in the screening of pulmonary arterial hypertension in patients with systemic sclerosis and indirect signs of pulmonary arterial hypertension.

Withdrawn6 enrollment criteria

Campath-1h Phase I/II Pilot Trial as Immunoablative Therapy for Refractory Systemic Sclerosis

Scleroderma

This phase I/II pilot trial seeks to demonstrate that prolonged administration of Campath-1H without prior marrow or stem cell harvesting can result in immunoablation similar to that achieved by hematopoietic stem cell transplantation (HSCT) from either bone marrow or peripheral blood stem cell sources in children and adolescents with severe treatment refractory systemic sclerosis (SSc).

Withdrawn40 enrollment criteria

Systemic Sclerosis Clinical and Biomarker Study

HealthySystemic Sclerosis

The primary objective of the study is to assess the change in systemic sclerosis (SSc)-associated gastrointestinal (GI) tract symptoms over a 1-year period in participants with SSc.

Withdrawn15 enrollment criteria

Post Marketing Surveillance Study of Cuprimine

Scleroderma

Cuprimine (penicillamine) was made available in the Philippines by the Sponsor under a Compassionate Special Permit issued by the Bureau of Food and Drugs. Physicians were able to request the drug for their patients from the Sponsor. A Clinical Study Report form was completed for each purchase of Cuprimine.

No longer available2 enrollment criteria

Seoul National University Hospital Systemic Sclerosis Cohort

Systemic Sclerosis

To establish a new prospective cohort of Korean patients with systemic sclerosis and track the natural history of the disease over time. To generate new hypotheses for further investigation.

Unknown status2 enrollment criteria

Screening Patients With Diabetes Mellitus for the Presence of Skin Disorder of Scleredema

Diabetes MellitusDiabetes Complications2 more

Scleredema is a scleroderma-like skin disorder appearing in 2.5-14% among patients with type 1 or 2 diabetes mellitus. This is a single centre study to screen consecutive patients with diabetes mellitus for the presence of scleredema,and to compare the clinical-laboratory data of patients with and without scleredema. Metabolic and vascular complications of these patients will be focused on.

Unknown status3 enrollment criteria

Non-interventional Study Describing Epidemiology, Prognosis and Patient Healthcare Costs in France,...

Lung DiseasesInterstitial1 more

Interstitial lung diseases (ILDs) are a heterogeneous group of disorders, which encompass a wide range of conditions. In some patients with fibrosing ILDs, a progressive phenotype similar to that observed in idiopathic pulmonary fibrosis (IPF) may develop during the course of the disease (PF-ILD), including patients with systemic sclerosis (SSc)-related ILD. The aim of the study is to estimate the incidence and prevalence and to describe the characteristics of patients diagnosed with non-IPF PF-ILD and SSc-ILD, to describe the natural course of disease, and to explore the correlation between mortality and Forced Vital Capacity (FVC) of the patients with non-IPF PF-ILD. This study will be based on two data sources: the French national medico administrative database (SNDS) and the ILD cohort from the National French center for rare pulmonary diseases in Lyon, France.

Unknown status4 enrollment criteria
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