
A Randomized Clinical Trial of Brace Treatment
Scoliosis; IdiopathicInfantileBrace treatment is the most effective non-surgical method for the treatment of Adolescent idiopathic scoliosis (AIS). The goal of bracing is to stop the curve progression during the high risk period of the adolescent growth spurt. A spinal brace is a hard plastic shell with pressure pads installed inside the liner to provide mechanical support to the curvature of the spine. It is a big commitment for adolescents to wear a brace because it is physically restrictive, uncomfortable and draws unwanted attention. Therefore, it is very important to make the brace treatment as effective as possible to get patient buy-in to compromise their lifestyle by wearing a brace. Patients' belief in the treatment outcomes is also a factor to attain their compliance. This randomized clinical study will investigate if the effectiveness of brace treatment can be maximized by combining ultrasound imaging assistance during brace design with the smart brace to automatically maintain corrective brace pressures at the optimum level during the whole treatment period.

Safety Outcomes of Vertebral Body Tethering Technique
Idiopathic Adolescent ScoliosisThe objectives of this study is to assess whether the intervention (Anterior Vertebral Tethering) is a safe and efficacious method of anterior approach surgery for spinal deformity in pediatric scoliosis.

Lumbar Interbody Implant Study
Degenerative Disc DiseaseDegenerative Spondylolisthesis3 moreThe objective of this study is to evaluate the safety and performance of NuVasive interbody implants when used during thoracic and/or lumbar spine surgery as measured by reported complications, radiographic outcomes, and patient-reported outcomes. This study is being undertaken to identify possible residual risks and to clarify mid- to long-term clinical performance that may affect the benefit/risk ratios of these interbody implants.

Adolescent Idiopathic Scoliosis and Proprioceptive Defect
Adolescent Idiopathic ScoliosisThis is the first research study to examine the peripheral and spinal proprioceptive deficits in AIS subjects in a comprehensive manner. It will determine normative values with reference to age, the relationship of proprioceptive changes to curve pattern, magnitude and progression, as well as whether all joints are equally affected, and thus address definitively the contribution of spinal proprioception to aetiology. Furthermore, as little is known about the measurement of proprioceptive sense, the present protocol from the study could be a reference measurement guide for detecting the proprioceptive sense in normal individuals, as well as to identify those with high risk for curve progression.

Clinical Study of Imaging and Endoplant-related Mechanical Complications After Long Segment Fixation...
Degenerative ScoliosisThere is a high probability of mechanical complications in patients with degenerative lumbar scoliosis after long segment fixation and fusion, and there are few studies on distal borderline kyphosis deformity/failure. This study was designed to retrospectively analyze the patients with degenerative lumbar scoliosis (DLS) who underwent posterior selective decompression and long segment fixation and fusion surgery in the lumbar spine department of our hospital from April 2009 to May 2016. Patients' basic data, surgical data and preoperative, immediate postoperative and follow-up imaging data were collected to study the incidence of distal mechanical complications, risk factors and their relationship with clinical symptom scores in DLS patients undergoing posterior selective decompression and long segment fixation and fusion. It has guiding significance for clinical operation decision making.

Rapid Postoperative Recovery Pathway in Adolescent Idiopathic Scoliosis.
Scoliosis Idiopathicthe study will evaluate the clinical outcomes of an intra- and postoperative fast-track protocol in patients undergoing instrumented posterior arthrodesis surgery for adolescent idiopathic scoliosis.

Genetic Study of Idiopathic Scoliosis in a Cohort of Families (SCOGEN)
Scoliosis IdiopathicThis study will focus on a large cohort of multiplex families, to precisely identify candidate genes. The fact of have a large database (fifty families, collected by the principal investigator for more than two decades), will contribute to the discovery of genes of interest. It will also allow testing for the presence or absence of mutations found in other cohorts in previous studies. The main objective of this study is to identify genetic abnormalities associated with the presence and severity of idiopathic scoliosis, in families of scoliosis.

Comparison of Reposition Sense in Scoliosis and Healthy Adolescents
Scoliosis; AdolescenceHealthy1 moreThe aim of the study is to compare the spine joint reposition sense in adolescent idiopathic scoliosis and healthy adolescents and to investigate whether there is a difference.

Scoliosis Survey to Development Treatment Decision Tool
Scoliosis; AdolescenceThis is a survey to help understand the influences related to the decision for Adolescent Idiopathic Scoliosis treatment (observation vs. bracing vs. surgery). The investigator then plans to create a decision aid to help families when making a decision about the treatment choice being presented to them.

Assessment of Skeletal Maturity Using Proximal Femoral Epiphysis in Patients With Scoliosis
Idiopathic ScoliosisThis study aims to explore the use of proximal femoral head for the assessment of skeletal maturity in patients with idiopathic scoliosis. The aim is to validate the use of the stages of proximal femoral epiphyseal closure in assessing pubertal growth landmarks in this patient cohort. The grading system of this skeletal maturity index will be established and its reliability and reproducibility in clinical use will be examined.