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Active clinical trials for "Neoplasms, Second Primary"

Results 141-150 of 267

Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine...

Solid Tumour Neoplastic MeningitisBrain Metastases

The purpose of this study is to demonstrate the safety of giving Whole Brain Radiotherapy (WBRT) together with intrathecal liposomal cytarabine (DepoCyte®) for patients with leptomeningeal metastases. The study will compare the safety of giving DepoCyte at the same time as WBRT with giving the drug after WBRT is complete.

Completed32 enrollment criteria

Study of NS-9 in Patients With Liver Metastases

Liver NeoplasmsNeoplasm Metastasis1 more

This study is to investigate the safety of NS-9 and to see how well it is tolerated in patients with cancer that has metastasized (spread) to the liver from another primary tumor. NS-9 is a drug developed to go to the liver to cause cell death specifically in tumor cells. This study is also set up to determine the best dose to use.

Completed32 enrollment criteria

Brain Metastases Study: Radiotherapy Fractionation Schemes in the Treatment of Brain Metastases...

Neoplasm MetastasisBrain Neoplasms

This is a comparison of radiotherapy fractionation schemes for brain metastasis.

Completed5 enrollment criteria

Study of Patupilone in Patients With Brain Metastasis From Non-small Cell Lung Cancer

Brain MetastasisNon-small Cell Lung Cancer

The study objective is to evaluate the safety and efficacy of patupilone with respect to early progression and response of patients with non-small cell lung cancer (NSCLC) metastatic to the brain, who have progressed after chemotherapy, surgery and/or radiation.

Completed22 enrollment criteria

Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases

PainNeoplasm Metastasis1 more

This study will evaluate the efficacy of cryoablation for palliation of painful metastases in participants with metastatic lesions involving bone who have failed, are not candidates for, or are not experiencing adequate pain relief from current pain therapies (for example, radiation, analgesics).

Completed21 enrollment criteria

Phase II Study of Ipilimumab Monotherapy in Recurrent Platinum-sensitive Ovarian Cancer

Platinum-sensitive Ovarian CancerSecond-line2 more

To assess the incidence of drug-related adverse events of Grade 3 or higher and the overall response associated with ipilimumab treatment

Completed23 enrollment criteria

Exploratory Study in Achievement of Improved Survival by Molecular Targeted Chemotherapy and Liver...

Liver MetastasisColorectal Cancer

The correlation between the values of angiogenesis-related growth factors in plasma and efficacy, and biomarkers relevant as prognostic factors or predictive factors for sensitivity or resistance to treatment will be examined exploratively.

Completed2 enrollment criteria

Stereotactic Body Radiation and Monoclonal Antibody to OX40 (MEDI6469) in Breast Cancer Patients...

Metastatic Breast CancerLung Metastases1 more

This study will test the investigational antibody, MEDI6469 (anti-OX40), in combination with stereotactic body radiation in breast cancer patients that have liver or lung metastases and have received systemic therapy and have progressive disease. The investigators hypothesize that SBRT directed at metastatic breast cancer lesions will result in a systemic anti-tumor immune system response. This amplified and directed immune response could result in anti-tumor responses.

Completed20 enrollment criteria

A Study of Prexasertib (LY2606368) in Combination With Ralimetinib in Participants With Advanced...

Advanced CancerMetastatic Cancer2 more

The main purpose of this study is to evaluate the safety of the study drug prexasertib in combination with ralimetinib in participants with advanced or metastatic cancer.

Completed14 enrollment criteria

SRS and Nivolumab in Treating Patients With Newly Diagnosed Melanoma Metastases in the Brain or...

Metastatic Malignant Neoplasm in the BrainMetastatic Malignant Neoplasm in the Spine1 more

This phase I pilot trial studies the side effects of stereotactic radiosurgery and nivolumab in treating patients with newly diagnosed melanoma that has spread to the brain or spine. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor to more precisely target the cancer. Monoclonal antibodies, such as nivolumab may interfere with the ability of tumor cells to grow and spread. Giving stereotactic radiosurgery together with nivolumab may be a better treatment for melanoma.

Completed26 enrollment criteria
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