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Active clinical trials for "Hyperparathyroidism, Secondary"

Results 121-130 of 173

ACHIEVE: Optimizing the Treatment of Secondary Hyperparathyroidism

Secondary Hyperparathyroidism

The purpose of this study is to compare the proportion of chronic kidney disease (CKD) subjects on dialysis receiving Sensipar® and low dose vitamin D or escalating doses of vitamin D alone who are able to achieve the National Kidney Foundation-Kidney Disease Outcomes Quality Initiative (NKF-K/DOQI) secondary hyperparathyroidism (HPT) treatment targets for both biointact parathyroid hormone (biPTH) and calcium-phosphorus (Ca x P) product.

Completed0 enrollment criteria

Investigation of the Optimal Calcium Supplement Following Roux-en-Y Gastric Bypass

Roux-en-Y Gastric BypassHyperparathyroidism1 more

This study investigates whether calcium citrate or calcium carbonate are the optimal supplement to treat secondary hyperparathyroidism following Roux-en-Y gastric bypass operation. Half of the participants will be randomized to receive calcium citrate, while the other half will receive calcium carbonate. The study will be double blinded.

Completed11 enrollment criteria

Efficacy and Safety of Cinacalcet in Ca, P and iPTH Levels in Patients With Mild, Moderate and Severe...

Hyperparathyroidism; SecondaryRenal

To evaluate achievement ratio of iPTH,Calcium and phosphorus after taking Cinacalcet HCL in hemodialysis subjects with mild, moderate and severe SHPT; To explore the impact of Cinacalcet HCL using on the combined use of drugs; To explore the difference of patients who continued or discontinued Cinacalcet HCL in real-world period from 33rd to 52nd week.

Completed19 enrollment criteria

A Study of Cinacalcet to Improve Achievement of National Kidney Foundation Kidney Disease Outcomes...

AnemiaSecondary Hyperparathyroidism

The purpose of this study is to show that the use of cinacalcet in patients with End Stage Renal Disease can help achieve NKF K/DOQI targets for both serum calcium and calcium phosphorous product.

Completed18 enrollment criteria

Trial to Optimize Mineral Outcomes in Dialysis Patients

Secondary HyperparathyroidismChronic Kidney Disease

This trial is designed to determine if the use of a computer algorithm designed to optimize mineral outcomes in dialysis patients increases the number of patients achieving the desired target endpoints for calcium, phosphorus and parathyroid hormone.

Completed11 enrollment criteria

Bioequivalency Study of Calcitriol Tablets Under Fasting Conditions

Secondary HyperparathyroidismHypocalcemia

The objective of this study was to assess the bioequivalence of Roxane Laboratories' Calcitriol capsules, 0.25 mcg, to ROCALTROL® capsules, 0.25 mcg (Roche) using a single-dose, 2-treatment, 2-period, crossover design, under fasting conditions

Completed4 enrollment criteria

A Phase 4 Study to Determine Dosing of Hectorol® Capsules When Converting From Zemplar® Injection...

Secondary Hyperparathyroidism

Protocol HECT00306 aims to determine clinically appropriate doses of Hectorol (doxercalciferol capsules) when converting from Zemplar (paricalcitol injection) for the treatment of secondary hyperparathyroidism in Stage 5 chronic kidney disease on hemodialysis.

Completed7 enrollment criteria

Prevention of Secondary Hyperparathyroidism With Vitamin D in Stage II/III Chronic Kidney Disease...

Kidney Disease

This study will evaluate whether earlier intervention with vitamin D in stage II/III chronic kidney disease will prevent or delay secondary hyperparathyroidism. Subjects will receive vitamin D or placebo at study entry and will be followed for a period of one year. The hypothesis is that subjects given vitamin D will have lower PTH and higher 25(OH)D after 1 year compared to placebo. Additionally, there will be less subjects who progress into secondary hyperparathyroidism in the vitamin D treated group compared to the placebo treated group.

Completed12 enrollment criteria

FGF-23 (Fibroblast Growth Factor 23) Regulation in Chronic Kidney Disease

Secondary Hyperparathyroidism

FGF-23 is a newly described protein that is an important regulator of phosphorus in the body. This protein increases in people with kidney disease and people who need dialysis have very high levels of FGF-23 in the blood. However, although some studies have indicated that FGF-23 levels go up with increased intake of phosphorus, no one knows if FGF-23 levels can be lowered in patients with kidney disease by preventing them from absorbing phosphorus from food. This study is designed to see what happens to levels of FGF-23 in the blood when patients with chronic kidney disease take medications to prevent phosphorus absorption. Since high levels of FGF-23 have been linked with increased rates of death in patients with advanced kidney disease, controlling the levels may, in the future, be a way to decrease heart disease in patients with kidney disease.

Completed0 enrollment criteria

Suspected Deficient Activation of Vitamin D in Patients With Secondary Hyperparathyroidism

Secondary Hyperparathyroidism

The purpose of this study is to determine if a reduction in the enzyme 1-hydroxylase, which activates Vitamin D, is the cause of overactivity of the parathyroid glands (called secondary hyperparathyroidism - normal blood calcium and elevated parathyroid hormone) in a selected group of young patients with normal kidney function.

Completed18 enrollment criteria
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