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Active clinical trials for "Alzheimer Disease"

Results 831-840 of 2939

Memantine and Antipsychotics Use

Alzheimer's Disease

To investigate the potential to reduce concomitant antipsychotic medication use in subjects with moderate dementia of Alzheimer's type, treated with memantine.

Terminated11 enrollment criteria

A Study to Evaluate the Safety, Tolerability, and Blood Levels of PF-03654746 in Subjects With Mild...

Alzheimer's Disease

This is a study to evaluate the safety, tolerability and blood levels of PF-03654746 in subjects will mild to moderate Alzheimer's disease.

Terminated6 enrollment criteria

A Phase 3 Efficacy Study Of Dimebon In Patients With Moderate To Severe Alzheimer's Disease

Alzheimer Disease

No Dimebon clinical data exist yet in patients with disease that has advanced to the moderate-to-severe stage. Therefore, this study evaluates the safety and efficacy of Dimebon in patients with moderate-to-severe AD who are receiving existing background therapy with memantine.

Terminated7 enrollment criteria

An Extension To The B1451006 Protocol To Evaluate The Safety and Efficacy of Dimebon In Subjects...

Alzheimer's Disease

The purpose of this study is to evaluate the long-term safety and tolerability of dimebon in subjects with moderate-to-severe Alzheimer's Disease.

Terminated2 enrollment criteria

Efficacy and Safety of Curcumin Formulation in Alzheimer's Disease

Alzheimer Disease

Curcumin is shown to impact several different pathways of neuroprotection, however clinical trials have not shown positive results, due to the poor bioavailability of curcumin. This study is designed to determine efficacy and safety of high-bioavailability curcumin formulation (Longvida) in subjects with Alzheimer's disease.

Terminated10 enrollment criteria

Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAM-315

Alzheimer Disease

Primary: To assess the safety and tolerability of ascending multiple oral doses of SAM-315, an investigational drug, in healthy young adult and elderly subjects. Secondary: To assess the Pharmacokinetic and Pharmacodynamic profiles of multiple oral doses of SAM-315 in healthy young adult and elderly subjects.

Terminated8 enrollment criteria

PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in HIV-Seropositive...

HIV-DementiaHIV-Associated Cognitive Motor Complex5 more

The purpose of this protocol is to measure a receptor in the brain using positron emission tomography (PET) that is involved in inflammation.

Terminated13 enrollment criteria

Lutein and Alzheimer's Disease Study

Alzheimer's Disease

Oxidative damage by free radicals may be involved in causing Alzheimer's disease (AD). Free radicals may lead to death of nerve cells and decline in brain function. Certain antioxidants may suppress this free radical damage associated with AD. Carotenoids are a family of naturally occurring antioxidants that have important functions for human health. Carotenoids are known to reduce oxidative damage, but their effects have not been studied in AD patients. The objective of the study is to examine whether lutein supplementation helps to reduce oxidative damage from free radicals in AD patients.

Terminated1 enrollment criteria

Treatment of Elderly Subjects With Psychosis and Behavioral Disturbances Associated With Dementia...

Psychosis and Behavioral Disturbances Associated With Dementia of the Alzheimer's Type

This is a 10-week study with bifeprunox and placebo in elderly subjects with psychosis and behavioral disturbances associated with dementia of the alzheimer's type.

Terminated4 enrollment criteria

Vaspect Study - An Open-Label Trial Of Donepezil in Vascular and Mixed Dementia

DementiaVascular2 more

To document effectiveness, safety, and tolerability of donepezil in patients with mixed AD/VaD, and to further document the effectiveness, safety, and tolerability of donepezil in patients with VaD. The effects of donepezil on executive functioning, behavior, general cognition, ADLs and global functioning will be assessed.

Terminated3 enrollment criteria
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