Active clinical trials for "Septo-Optic Dysplasia"

Hypotheses: The prevalence of endocrinopathies, and growth hormone (GH) deficiency in particular, among young children diagnosed with optic nerve hypoplasia (ONH) is higher than is commonly thought. Early treatment of children with ONH and GH-deficiency can prevent adverse outcomes. Aims: Determine the prevalence and types of endocrinopathies in children diagnosed with ONH. Correlate endocrine outcome with radiographic, ocular, and developmental findings in children with ONH. Examine the effect of GH treatment on growth and obesity in children with ONH, GH-deficiency, and either subnormal or normal growth compared to children with ONH that are not GH-deficient. Compare growth outcomes between children with isolated GH-deficiency and those with multiple hormone deficiencies.

Evaluation of prenatal optic chiasm (OC) is important for the differential diagnosis of septo-optic dysplasia (SOD), which is a congenital optic disc anomaly, and the absence of the cavum septum pellucidum (CSP). Septo-optic dysplasia is associated with a wide range of neurological abnormalities, including hypoplasia of the visual pathways, CSP agenesis, and developmental delay.