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Active clinical trials for "Short Bowel Syndrome"

Results 111-120 of 122

Intestinal Microbial Dysbiosis in Chinese Infants With Short Bowel Syndrome With Different Complications...

Short Bowel SyndromeComplications

There are no reports involved the intestinal microbiota from Chinese infants with short bowel syndrome (SBS) under different clinical status. Alterations in the microbiota are closely correlated with the bile acids and short chain fatty acids metabolism as well as the intestinal immunity. A relatively comprehensive profile composed of microbial structure, microbial metabolism products and immune biomarkers in SBS infants may facilitate a better therapy strategy to complications occurred in SBS children.

Completed1 enrollment criteria

Mechanisms of Adaptation in Human Short Bowel Syndrome

Short Bowel Syndrome

This is an observational, natural history trial of mechanisms of gut adaptation in adult short bowel syndrome (SBS). Patients with SBS (< 200 cm small bowel ± colon) will be studied initially 2-9 months after the last small bowel resection and again exactly 6 months after the initial study. GCRC-studies will examine intestinal nutrient absorption, gut barrier functions and gut mucosal biopsy specimens for markers of nutrient transport and cell proliferation and apoptosis.

Completed2 enrollment criteria

Teduglutide in Short Bowel Syndrome Patients

Short Bowel Syndrome

A retrospective analysis was performed using data of patients suffering from non-malignant SBS-IF. They were treated with teduglutide in a multidisciplinary SBS-IF program at a single university medical center between June 2016 and June 2020.

Completed4 enrollment criteria

Compassionate Use of Omegaven for Pediatric Patients With Parenteral Nutrition Associated Liver...

CholestasisShort Bowel Syndrome

A compassionate use protocol to provide Omegaven to pediatric patients with parenteral nutrition (PN) dependence and parenteral nutrition associated liver disease (PNALD).

Approved for marketing11 enrollment criteria

Energy Metabolism in Patients With Short Bowel Syndrome

Short Bowel Syndrome

This study proposes to verify the total energy expenditure in patients with short bowel syndrome using the doubly labeled water method, as well as determining the rate of oxidation of nutrients, aiming to assist the management of nutritional therapy for these patients.

Completed3 enrollment criteria

Magnetic Resonance (MR) Enterography Assessment of Post Operative Small Bowel Length in Short Bowel...

Short Bowel Syndrome

It is essential to know intestinal length and anastomotic type in post-operative short bowel syndrome patients. These parameters can help predict long-term intestinal failure with long-term parenteral nutrition usually needed for smallest lengths. Sometimes these parameters are unfortunately missing for lack of intraoperative measurement. Thus, it is necessary to develop non-invasive and reproducible techniques to assess small bowel length. This is the reason why the investigators will evaluate magnetic resonance (MR)-enterography and barium follow-through in this indication. There are at this time only two small studies evaluating barium follow-through for intestinal length measurement, and none evaluating MR-enterography. However, a major advantage of the latter is the lack of radiation exposure and possibility to perform 3D. This will be an open labelled single center crossover study. Short bowel syndrome patients of the investigators center will be included after consent. The sequence of exams (MR enterography followed by barium follow-through or vice-versa) will be randomly assigned. Peroperative short bowel length measurement will be available for all patients. There will be one month between the two exams. The main objective of this study is to assess the performance of MR-enterography in short bowel measurement in short bowel syndrome patients, the gold standard being peroperative length. Secondary objectives are to assess the performance of barium follow-through in short bowel measurement in these patients, and to show that barium follow-through does not perform better than MR-enterography. For that purpose the investigators will include 50 patients over 2 years.

Unknown status10 enrollment criteria

Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure...

Short Bowel Syndrome

This study will determine if air-displacement plethysmography (ADP) provides accurate measurement of body composition (percent body fat and fat-free mass) in pediatric patients with intestinal failure, as compared to body composition measured by alternative standard methods, including deuterium dilution, bioimpedance analysis (BIA), dual x-ray absorptiometry (DXA) when clinically indicated, and routine anthropometric measurements.

Completed6 enrollment criteria

Quality of Life in Patients With Short Bowel Syndrome Treated Without and With Teduglutide - a Prospective...

Short Bowel SyndromeIntestinal Failure

The aim of this prospective longitudinal study is to compare the quality of life of short bowel patients prior to and on teduglutide treatment with a non-treated patient group in a matched-pair design.

Unknown status5 enrollment criteria

Evaluation of 70% Ethanol Lock Solution to Prevent Catheter Related Blood Stream Infections in Pediatric...

Blood Stream InfectionsShort Bowel Syndrome

The purpose of this study is to evaluate the clinical practice of the prophylactic use of ethanol locks for the prevention of catheter related blood stream infections in pediatric intestinal rehabilitation program patients requiring total parenteral nutrition.

Withdrawn12 enrollment criteria

Safer Parenteral Nutrition in Pediatric Short Bowel Syndrome to Decrease Liver Damage

Cholestasis of Parenteral Nutrition

To provide children dependent on total parenteral nutrition with Omegaven®, a fish oil-based intravenous lipid emulsion that may be less hepatotoxic than conventional, vegetable oil-based intravenous lipid emulsions, and that may therefore reduce the need for liver transplantation.

Approved for marketing12 enrollment criteria
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