Cancer Sensing: Evaluation of Odour Sampling Techniques
Skin CancerTo evaluate the suitability of two odour capturing techniques for early detection of skin cancer.
Non-Linear Imaging of Skin In Vivo
Skin CancerThe overall objective of this study is to investigate the potential for Enspectra Investigational Device to display microscopic skin structure in people of different age, sex, race, and skin health.
Itch and Pain Characteristics in Skin Carcinomas
Skin CarcinomaSkin Cancer1 moreThe objective of this study is to have better knowledge about sensations of patients with skin carcinomas and to have data about characteristics of pain and pruritus . All patients presenting with a suspicions lesion for skin carcinomas will be included and will respond to a questionnaire. Demographics data, and histological data about skin carcinomas will be collected.
Viral Reactivation and Skin Cancer
Skin CancerInfection ReactivationSeveral studies show that the incidence of skin cancer parallels the length and depth of immunosuppression. This study will analyze the correlation of viral reactivation and skin cancer in organ transplant recipients.
Spectrally Guided Mohs Surgery
Skin CancerFreshly excised or freshly frozen tissue for Raman analysis will be obtained from a dermatology practice affiliated with UMCB. In the course of the routine removal of benign or malignant tumors in the office, skin cancer surgeons routinely check frozen sections to ensure adequate margins are obtained. Consent will be obtained from patients to provide freshly excised or freshly frozen leftover tissue obtained during Mohs surgery to be discarded after histological diagnosis. Freshly excised tissue will be measured at the time of excision before processing, while the freshly frozen tissue samples will be stored in a freezer at the Mohs clinic and transferred to the UT- Austin campus for spectroscopic analysis.
A Study of Ultrasonography With Elastography in Skin Neoplasms
Benign and Malignant Skin NeoplasmsThis study will look at high frequency ultrasound as a medical imaging modality and apply it to skin lesions. Elastography is an ultrasonic method of looking at the hardness of an area. We will use this to try and differentiate between benign and cancerous skin lesions.
Expression Levels of microRNA Processing Enzymes Dicer and Drosha in Epithelial Skin Cancer
Skin CancerMicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study the expression profiles for the two most important miRNA processing enzymes Dicer and Drosha of actinic keratoses, basal cell carcinoma and squamous cell carcinoma are compared to healthy skin tissue.
Spectral Diagnosis of Cutaneous Malignancy
Skin CancerThe goal of this clinical research study is to evaluate the use of an imaging technology called spectral diagnosis. Researchers want to find out if a special spectral-diagnosis probe can be used to detect skin cancers.
Skin Ageing Signatures and Cancer
Skin CancerThe aim of this study is to identify genetic patterns in normal ageing skin in order to better understand age-related changes. Data has suggested that skin ageing has a genetic basis and past studies have identified genes that promote skin aging due to sun exposure.
How Microbes and Metabolism May Predict Skin Cancer Immunotherapy Outcomes
AutoimmunityMelanoma4 moreThe purpose of this research study is to examine the relationship between the microbiota (microscopic organisms) in the gut and the activity of the immune system during skin cancer immunotherapy.