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Active clinical trials for "Sleep Apnea, Central"

Results 61-70 of 75

Prospective Evaluation of Heart Failure Patients With Central Sleep Apnea

Central Sleep ApneaHeart Failure

Central sleep apnea (CSA) has been associated with increased mortality and primarily occurs in patients with heart failure (HF). The primary purpose of this study is to document the natural progression of moderate to severe CSA in heart failure patients.

Terminated16 enrollment criteria

Sparkle Respiratory Effort Validation

Sleep ApneaObstructive2 more

This study has been developed in order to demonstrate the validity of the Sparkle respiratory effort signal.

Withdrawn12 enrollment criteria

Effect of Adaptive Servoventilation on Cardiac Function in Chronic Heart Failure and Cheyne-Stokes...

Chronic Heart FailureCentral Sleep Apnea1 more

Sleep disordered breathing is common in patients with chronic heart failure. Adaptive servoventilation is a novel method of treatment central sleep apnoea, especially associated with Cheyne-Stokes-respiration. The aim of the study is to investigate effect of adaptive servoventilation on cardiac function, exercise tolerance and quality of life in patients with chronic heart failure.

Unknown status8 enrollment criteria

Heart Function in Patients Assessed for Sleep Apnoea

Heart Failure With Preserved Ejection FractionSleep Disordered Breathing4 more

This study aims to determine the prevalence and prognosis of heart failure with preserved ejection function (HFpEF) among patients being assessed for sleep disordered breathing (SDB).

Completed3 enrollment criteria

Late-onset Congenital Central Hypoventilation Syndrome and the Mutation of Phox2B Gene

Congenital Central Hypoventilation Syndrome

Congenital central hypoventilation syndrome (CCHS) is a rare disorder of respiratory control characterized by ventilatory impairment that results in arterial hypoxemia. Although patients typically present this disease as newborns and rarely in later infancy, there have been reports of patients presenting with CCHS in adulthood. The present study reports a unique familial case in which the father (proband) presented late-onset CCHS with an expansion mutation of the Phox2B gene that was confirmed by genetic analysis. Surprisingly, the proband did not report any manifestation of the disease during childhood, and the disease progressed following an insidious course until adulthood. At the time of diagnosis, he did not present signs of pulmonary hypertension and right-side heart failure. The patient responded well to nocturnal invasive ventilation. In contrast, his son presented CCHS as a newborn with the full complement of symptoms while his daughter did not. The present report shows that CCHS cases characterized by a mutated Phox2 gene can progress without many symptoms and that the treatment approach used here was efficient for controlling the course of the disease. Furthermore, this case indicates that incomplete penetrance can occur. Genetic screening of family members is mandatory to evaluate the reproductive risk of the disease, especially because asymptomatic mutation carriers may be at high risk to develop the disease and transmit it to the next generation.

Completed0 enrollment criteria

Pre-operative Polysomnography Assessment of Cardiac Surgery Inpatients

Sleep Disordered BreathingObstructive Sleep Apnea1 more

The purpose of this study is to assess the prevalence and morbidity rates of sleep disordered breathing in cardiac surgery patients.

Completed5 enrollment criteria

A Multi-Center Study to Assess the Performance of Saturation Patterns.

Sleep-Disordered BreathingObstructive Sleep Apnea2 more

A multi-center, prospective, single-visit study designed to acquire physiologic pulse oximeter waveform data during standard polysomnography (PSG) studies performed at multiple different Sleep Lab Centers.

Completed5 enrollment criteria

A Prospective Multicenter Registry of Patients With Sleep Disordered Breathing Treated With DreamStation...

Central Sleep ApneaMixed Sleep Apnea2 more

This multi-center observational study will prospectively collect data from patients who have an indication for servo ventilation therapy. This registry is intended to characterize the patient populations that may benefit from DreamStation BiPAP autoSV therapy (PR DS-autoSV, Philips Respironics, Monroeville, PA) in real life settings. In addition, this registry will assess adherence to the PR DS-autoSV therapy, the therapeutic benefits, collect morbidity and mortality data of servo ventilation in patients with central sleep apnea (CSA) and complex sleep-disordered breathing (SDB).

Completed11 enrollment criteria

Cognitive Consequences of an Activation of the Cortical Drive to Breath (VENTIPSY)

Ondine SyndromeHealthy1 more

The purpose of the study is to measure the negative cognitive consequences of the ventilation under pathological or experimental cortical drive to breath.

Completed17 enrollment criteria

French Cohort Study of Chronic Heart Failure Patients With Central Sleep Apnoea Eligible for Adaptive...

Central Sleep ApneaHeart Failure

The purpose of this study is to determine the predictive factors of poor compliance to sleep disordered breathing therapy in chronic heart failure patients treated for central sleep apnea. To characterize nocturia pathophysiology associated with SDB in this population. To use telemonitoring data to define predictive factors of poor compliance.

Withdrawn5 enrollment criteria
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