Prospective Evaluation of Heart Failure Patients With Central Sleep Apnea
Central Sleep ApneaHeart FailureCentral sleep apnea (CSA) has been associated with increased mortality and primarily occurs in patients with heart failure (HF). The primary purpose of this study is to document the natural progression of moderate to severe CSA in heart failure patients.
Sparkle Respiratory Effort Validation
Sleep ApneaObstructive2 moreThis study has been developed in order to demonstrate the validity of the Sparkle respiratory effort signal.
Effect of Adaptive Servoventilation on Cardiac Function in Chronic Heart Failure and Cheyne-Stokes...
Chronic Heart FailureCentral Sleep Apnea1 moreSleep disordered breathing is common in patients with chronic heart failure. Adaptive servoventilation is a novel method of treatment central sleep apnoea, especially associated with Cheyne-Stokes-respiration. The aim of the study is to investigate effect of adaptive servoventilation on cardiac function, exercise tolerance and quality of life in patients with chronic heart failure.
Heart Function in Patients Assessed for Sleep Apnoea
Heart Failure With Preserved Ejection FractionSleep Disordered Breathing4 moreThis study aims to determine the prevalence and prognosis of heart failure with preserved ejection function (HFpEF) among patients being assessed for sleep disordered breathing (SDB).
Late-onset Congenital Central Hypoventilation Syndrome and the Mutation of Phox2B Gene
Congenital Central Hypoventilation SyndromeCongenital central hypoventilation syndrome (CCHS) is a rare disorder of respiratory control characterized by ventilatory impairment that results in arterial hypoxemia. Although patients typically present this disease as newborns and rarely in later infancy, there have been reports of patients presenting with CCHS in adulthood. The present study reports a unique familial case in which the father (proband) presented late-onset CCHS with an expansion mutation of the Phox2B gene that was confirmed by genetic analysis. Surprisingly, the proband did not report any manifestation of the disease during childhood, and the disease progressed following an insidious course until adulthood. At the time of diagnosis, he did not present signs of pulmonary hypertension and right-side heart failure. The patient responded well to nocturnal invasive ventilation. In contrast, his son presented CCHS as a newborn with the full complement of symptoms while his daughter did not. The present report shows that CCHS cases characterized by a mutated Phox2 gene can progress without many symptoms and that the treatment approach used here was efficient for controlling the course of the disease. Furthermore, this case indicates that incomplete penetrance can occur. Genetic screening of family members is mandatory to evaluate the reproductive risk of the disease, especially because asymptomatic mutation carriers may be at high risk to develop the disease and transmit it to the next generation.
Pre-operative Polysomnography Assessment of Cardiac Surgery Inpatients
Sleep Disordered BreathingObstructive Sleep Apnea1 moreThe purpose of this study is to assess the prevalence and morbidity rates of sleep disordered breathing in cardiac surgery patients.
A Multi-Center Study to Assess the Performance of Saturation Patterns.
Sleep-Disordered BreathingObstructive Sleep Apnea2 moreA multi-center, prospective, single-visit study designed to acquire physiologic pulse oximeter waveform data during standard polysomnography (PSG) studies performed at multiple different Sleep Lab Centers.
A Prospective Multicenter Registry of Patients With Sleep Disordered Breathing Treated With DreamStation...
Central Sleep ApneaMixed Sleep Apnea2 moreThis multi-center observational study will prospectively collect data from patients who have an indication for servo ventilation therapy. This registry is intended to characterize the patient populations that may benefit from DreamStation BiPAP autoSV therapy (PR DS-autoSV, Philips Respironics, Monroeville, PA) in real life settings. In addition, this registry will assess adherence to the PR DS-autoSV therapy, the therapeutic benefits, collect morbidity and mortality data of servo ventilation in patients with central sleep apnea (CSA) and complex sleep-disordered breathing (SDB).
Cognitive Consequences of an Activation of the Cortical Drive to Breath (VENTIPSY)
Ondine SyndromeHealthy1 moreThe purpose of the study is to measure the negative cognitive consequences of the ventilation under pathological or experimental cortical drive to breath.
French Cohort Study of Chronic Heart Failure Patients With Central Sleep Apnoea Eligible for Adaptive...
Central Sleep ApneaHeart FailureThe purpose of this study is to determine the predictive factors of poor compliance to sleep disordered breathing therapy in chronic heart failure patients treated for central sleep apnea. To characterize nocturia pathophysiology associated with SDB in this population. To use telemonitoring data to define predictive factors of poor compliance.