Ultrasonographic Measurements of the Achilles Tendon and Talar Condylar Cartilage Thickness in Paraplegia...
ParaplegiaInvestigators aim to measure the ankle talar cartilage and achilles tendon thicknesses ultrasonographically in paraplegic patients and compare them with the normal population.
Natural History of Shoulder Pathology in Manual Wheelchair Users
ParaplegiaSpinal Cord Injuries2 moreOver 300,000 people in the United States have spinal cord injuries and many use manual wheelchairs for mobility. Most manual wheelchair users will develop shoulder injuries and pain that greatly affect quality of life and level of independence. Understanding when shoulder disease starts in manual wheelchair users and which daily activities contribute to the disease will provide necessary evidence for effective primary prevention methods to inhibit the development of further disability. Our central hypothesis is that the development of shoulder disease in manual wheelchair users will be strongly associated with the cumulative exposure to elevated shoulder postures combined with high upper body loading.
Study of Disease Progression in Adults With Inherited Forms of Spastic Paraplegia
AMNAMN Gene Mutation1 moreThe course of AMN-related disabilities over time is poorly or incompletely understood due to a limited number of patients and lack of treatments. This study will help obtain a better understanding of the progression of disease with AMN and facilitate efficient clinical development of future interventional medications.
Activity-Dependent Transspinal Stimulation in SCI
Spinal Cord InjuriesParaplegia4 moreRobotic gait training is often used with the aim to improve walking ability in individuals with Spinal Cord Injury. However, robotic gait training alone may not be sufficient. This study will compare the effects of robotic gait training alone to robotic gait training combined with either low-frequency or high-frequency non-invasive transspinal electrical stimulation. In people with motor-incomplete SCI, a series of clinical and electrical tests of nerve function will be performed before and after 20 sessions of gait training with or without stimulation.
Spinal Cord Injury Leg Rehabilitation
Spinal Cord InjuryParaplegia2 moreThe purpose of this study is to determine if individuals with incomplete spinal cord injury (SCI) who remain unable to walk normally 1 year after their SCIs are able to sense and move the affected legs better after 10-13 weeks of treatment with a new robotic therapy device. The hypothesis is that using the AMES device on the legs of chronic subjects with incomplete SCI will result in improved strength, sensation in the legs, and improved functional gait in the treated limbs.
Effects of Transvertebral Direct Current Stimulation in Humans
Spinal Cord InjuriesParaplegia and TetraplegiaThis study will evaluate the effects of non-invasive stimulation of the spinal cord in people with spinal cord injury.
Phenotype, Genotype & Biomarkers in ALS and Related Disorders
Amyotrophic Lateral SclerosisFrontotemporal Dementia4 moreThe goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA), and frontotemporal dementia (FTD); and (2) to develop biomarkers that might be useful in aiding therapy development for this group of disorders.
Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5
Spastic ParaplegiaHereditaryThe purpose of this project is to study the efficacy of three candidate molecules (Xenbilox, Tahor and Resveratrol) in order to decrease the production of oxysterols by reducing the synthesis of cholesterol and/or regulate the production of bile acids and/or enabling neuroprotective action within the motor neuron.
The Safety of ahSC in Chronic SCI With Rehabilitation
Spinal Cord InjuryParaplegia2 moreThe purpose of this study is to assess the safety of autologous human Schwann cell (ahSC) transplantation in participants with chronic SCI. This trial design is phase I, open label, unblinded, non-randomized, and non-placebo controlled multiple injury cohorts.
Use of Interactive Gaming for Enhanced Function After Spinal Cord Injury
Paraplegia and TetraplegiaThe purpose of this study is to evaluate whether there are functional improvements in arm muscles and movments for spinal cord injured indviduals after performing video gaming.