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Active clinical trials for "Paraplegia"

Results 31-40 of 104

Ultrasonographic Measurements of the Achilles Tendon and Talar Condylar Cartilage Thickness in Paraplegia...

Paraplegia

Investigators aim to measure the ankle talar cartilage and achilles tendon thicknesses ultrasonographically in paraplegic patients and compare them with the normal population.

Active5 enrollment criteria

Natural History of Shoulder Pathology in Manual Wheelchair Users

ParaplegiaSpinal Cord Injuries2 more

Over 300,000 people in the United States have spinal cord injuries and many use manual wheelchairs for mobility. Most manual wheelchair users will develop shoulder injuries and pain that greatly affect quality of life and level of independence. Understanding when shoulder disease starts in manual wheelchair users and which daily activities contribute to the disease will provide necessary evidence for effective primary prevention methods to inhibit the development of further disability. Our central hypothesis is that the development of shoulder disease in manual wheelchair users will be strongly associated with the cumulative exposure to elevated shoulder postures combined with high upper body loading.

Active18 enrollment criteria

Study of Disease Progression in Adults With Inherited Forms of Spastic Paraplegia

AMNAMN Gene Mutation1 more

The course of AMN-related disabilities over time is poorly or incompletely understood due to a limited number of patients and lack of treatments. This study will help obtain a better understanding of the progression of disease with AMN and facilitate efficient clinical development of future interventional medications.

Active6 enrollment criteria

Activity-Dependent Transspinal Stimulation in SCI

Spinal Cord InjuriesParaplegia4 more

Robotic gait training is often used with the aim to improve walking ability in individuals with Spinal Cord Injury. However, robotic gait training alone may not be sufficient. This study will compare the effects of robotic gait training alone to robotic gait training combined with either low-frequency or high-frequency non-invasive transspinal electrical stimulation. In people with motor-incomplete SCI, a series of clinical and electrical tests of nerve function will be performed before and after 20 sessions of gait training with or without stimulation.

Terminated15 enrollment criteria

Spinal Cord Injury Leg Rehabilitation

Spinal Cord InjuryParaplegia2 more

The purpose of this study is to determine if individuals with incomplete spinal cord injury (SCI) who remain unable to walk normally 1 year after their SCIs are able to sense and move the affected legs better after 10-13 weeks of treatment with a new robotic therapy device. The hypothesis is that using the AMES device on the legs of chronic subjects with incomplete SCI will result in improved strength, sensation in the legs, and improved functional gait in the treated limbs.

Terminated21 enrollment criteria

Effects of Transvertebral Direct Current Stimulation in Humans

Spinal Cord InjuriesParaplegia and Tetraplegia

This study will evaluate the effects of non-invasive stimulation of the spinal cord in people with spinal cord injury.

Terminated18 enrollment criteria

Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Amyotrophic Lateral SclerosisFrontotemporal Dementia4 more

The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA), and frontotemporal dementia (FTD); and (2) to develop biomarkers that might be useful in aiding therapy development for this group of disorders.

Enrolling by invitation6 enrollment criteria

Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5

Spastic ParaplegiaHereditary

The purpose of this project is to study the efficacy of three candidate molecules (Xenbilox, Tahor and Resveratrol) in order to decrease the production of oxysterols by reducing the synthesis of cholesterol and/or regulate the production of bile acids and/or enabling neuroprotective action within the motor neuron.

Completed19 enrollment criteria

The Safety of ahSC in Chronic SCI With Rehabilitation

Spinal Cord InjuryParaplegia2 more

The purpose of this study is to assess the safety of autologous human Schwann cell (ahSC) transplantation in participants with chronic SCI. This trial design is phase I, open label, unblinded, non-randomized, and non-placebo controlled multiple injury cohorts.

Completed28 enrollment criteria

Use of Interactive Gaming for Enhanced Function After Spinal Cord Injury

Paraplegia and Tetraplegia

The purpose of this study is to evaluate whether there are functional improvements in arm muscles and movments for spinal cord injured indviduals after performing video gaming.

Completed2 enrollment criteria
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