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Active clinical trials for "Spinal Cord Diseases"

Results 71-80 of 179

Vaporized Cannabis and Spinal Cord Injury Pain

Spinal Cord InjuriesSpinal Cord Diseases

This study will demonstrate that vaporized marijuana results in antinociception when compared to placebo in subjects with spinal cord injury. To further evaluate potential benefits and side effects, the effect of different strengths of cannabis on mood, cognition, and psychomotor performance will also be measured.

Completed12 enrollment criteria

The CSM Trial: A Multicenter Study Comparing Ventral to Dorsal Surgery for Cervical Spondylotic...

Cervical Spondylotic Myelopathy

The purpose of the study is to determine the optimal surgical approach (ventral versus dorsal) for patients with multi-level cervical spondylotic myelopathy (CSM). There are no established guidelines for the management of patients with CSM, which slowly causes spinal cord injury in afflicted patients. This study aims to test the hypothesis that ventral surgery (decompressing the spinal cord from the front of the neck) and dorsal surgery (decompressing the spinal cord from the back of the neck) might differ in their overall outcome or major complication rate.

Completed5 enrollment criteria

An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain

Spinal Cord DiseasesSpinal Cord Injuries2 more

The purpose of this study is to assess the safety of the long-term use of pregabalin at doses up to 600 mg/day in patients with central neuropathic pain (post spinal cord injury pain, post stroke pain, and multiple sclerosis pain).

Completed8 enrollment criteria

Safety Study of Preservon-Treated Bone Implants for Cervical Fusion in the Treatment of Cervical...

Cervical RadiculopathyMyelopathy

The purpose of this study is to compare the safety and efficacy of Preservon(TM) treated allograft bone dowels to traditional freeze-dried allograft bone dowels (control) for fusion of degenerated cervical intervertebral discs in the treatment of cervical radiculopathy or myelopathy. Patient follow-up will be conducted at 6 weeks, 3 months, and 6 months. At 3 months after surgery, the implanted bone dowels will be assessed for subsidence; at 6 months after surgery, the implanted bone dowels will be assessed for fusion. Patients will complete questionnaires and x-rays taken at each visit. The degree of subsidence and rate of fusion will be assessed based on the evaluation of the x-rays taken. The x-ray evaluation will be conducted by a neurosurgeon who is blinded to the type of treatment that each patient has received.

Completed21 enrollment criteria

NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain

Disease (or Disorder); Intervertebral DiscWith Myelopathy (Manifestation)

This is a multiple-dose, double-blind, double-dummy, active-control, parallel-group, multi-center, safety and efficacy study.

Completed23 enrollment criteria

Treatment of AIDS Vacuolar Myelopathy With Methionine

MyelopathyAIDS-Myelopathy1 more

The purpose of this study is to determine whether methionine, an amino acid present in low doses in the normal diet, can improve myelopathy or stop its progression.

Completed1 enrollment criteria

AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral SclerosisMotor Neuron Disease6 more

The CENTAUR trial was a 2:1 (active:placebo) randomized, double-blind, placebo-controlled Phase II trial to evaluate the safety and efficacy of AMX0035 for the treatment of ALS.

Completed26 enrollment criteria

Treatment of Sleep-disordered Breathing in Patients With SCI

Spinal Cord InjurySleep-disordered Breathing2 more

Sleep-disordered breathing (SDB) remains under-treated in individuals living with spinal cord injuries and disorders (SCI/D). The investigators' aim is to test a program that addresses challenges and barriers to positive airway pressure (PAP) treatment of SDB among patients with SCI/D. The investigators anticipate that patients who receive this program will have higher rates of PAP use and will demonstrate improvements in sleep quality, general functioning, respiratory functioning and quality of life from baseline to 6 months follow up compared to individuals who receive a control program. This work addresses critical healthcare needs for patients with SCI/D and may lead to improved health and quality of life for these patients.

Completed13 enrollment criteria

Efficacy of Riluzole in Surgical Treatment for Cervical Spondylotic Myelopathy (CSM-Protect)

Cervical Spondylotic Myelopathy

CSM (Cervical spondylotic myelopathy) is the most common cause of spinal cord injury worldwide. While there is evidence from the recently completed SpineNet prospective study that surgical decompression is an effective treatment for CSM, it is clear that many patients have remaining neurological impairment. While surgery is relatively safe, approximately 3% of patients maintain a neurological problem. Given this background and data from preclinical models of non-traumatic and traumatic spinal cord injury, there is strong evidence to consider the potential benefit of adding a neuroprotective drug which aids in the treatment of patients with CSM whom are undergoing surgical decompression. Riluzole is FDA-approved for the treatment of amyotrophic lateral sclerosis, which has some similar clinical features to CSM. Riluzole is currently under investigation for traumatic spinal cord injury. Given this background, there is a strong basis to consider studying the potential neurological benefits of Riluzole as a treatment to surgical decompression in patients with CSM.

Completed58 enrollment criteria

The Study About the Efficacy of Oral Limaprost After Surgery for Cervical Myelopathy

Cervical Myelopathy

The limaprost alfadex can improve the surgical outcomes in patients with cervical myelopathy.

Completed14 enrollment criteria
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