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Active clinical trials for "Spinal Diseases"

Results 81-90 of 242

Anderson Circulating Tumor Cell Burden (CTCB) Study

CancerSpinal Disease1 more

Phase 1 - Optimization Phase: Primary Objective: The primary objective of Phase 1 of this study is to determine the time point at which maximal Circulating Tumor Cell Burden (CTCB) occurs following standard vertebroplasty and Kyphoplasty procedures relative to baseline CTCB. Phase 2 - Comparison Phase: Primary Objective: The primary objective of Phase 2 of this study is to determine the change in CTCB from baseline to post-treatment as measured using the CellSearch™ Assay and to compare the average change between treatment groups with and without the use of the Cavity SpineWand. Secondary Objectives: To determine the change in self-reported pain level from baseline to post-treatment as measured using the visual analogue scale (VAS) for spine pain and to compare the average change in pain level between treatment groups. To determine the change in pain status from baseline to post-treatment as measured using the Brief Pain Inventory (BPI) and to compare the average change in pain status between treatment groups. To determine the change from baseline to post-treatment in the M.D. Anderson Cancer Center Symptom Inventory (MDASI) and to compare the average change between treatment groups. To determine the change from baseline to post-treatment in time to walk a 50-foot distance and to compare the average change between treatment groups.

Terminated17 enrollment criteria

A Phase I/II Study of AGA111 for Lumbar Interbody Fusion in Patients With Degenerative Disc Disease...

Degenerative Disc Disease

The objectives of the study are to evaluate the safety and preliminary efficacy of a single administration of AGA111 for lumbar interbody fusion in patients with degenerative disc disease.

Completed20 enrollment criteria

Stabilizing Training in Degenerative Disc Disease

Degenerative Disc DiseaseProtrusion2 more

This study evaluates efficacy of stabilizing training of deep core muscles in the lumbar spine in degenerative disc disease subjects, considering the progression level of degenerative disc disease: protrusion or extrusion.

Completed10 enrollment criteria

Efficacy of Exercise, Manual Therapy and Tele-rehabilitation-Assisted Treatment on Degenerative...

Cervical Spine DiseaseNeck Pain

The study aims to compare the effectiveness of soft tissue, joint mobilization, and tele-rehabilitation within the scope of Manual Therapy to the exercise program.

Completed15 enrollment criteria

The Effect of Oral Vitamin D Supplements on Fusion Outcome in Patients Receiving Elective Lumbar...

Vitamin DSpinal Fusion1 more

The process of bony fusion is a dynamic bone remodeling process and a variety of risk factors have been identified to contribute to pseudoarthrosis.Vitamin D deficiency has been reported to be associated with more pseudoarthrosis, prolonged time to fusion, and poorer spine function and quality of life after spinal fusion.However, as the review article presented, it lacks high-quality evidence to investigate the role of vitamin D supplements in spinal fusion. Therefore, this randomized controlled trial aimed to evaluate the effectiveness of oral vitamin D supplements on fusion outcomes in patients receiving elective lumbar spinal fusion.

Completed9 enrollment criteria

A Study of SI-6603 in Patients With Lumbar Disc Herniation

Intervertebral Disc DiseaseLumbar Disc Disease

The purpose of this study is to evaluate the efficacy and safety of SI-6603 (condoliase) in patients with lumbar disc herniation.

Completed8 enrollment criteria

A Pilot Study of rhBMP-2/ACS/Allograft Bone Dowel for Anterior Lumbar Interbody Fusion in Patients...

Degenerative Disc Disease

The purpose of this pilot clinical trial is to evaluate the device design as a method of facilitating spinal fusion.

Completed34 enrollment criteria

A-MAV™ Anterior Motion Segment Replacement

Spinal Diseases

The purpose of this clinical trial is to collect safety and effectiveness data concerning the A-MAV™ Anterior Motion Segment Replacement device as a method of treating patients with lumbar degenerative disc disease at one level from L4-S1. Overall success will be the primary clinical endpoint.

Completed48 enrollment criteria

XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease...

Degenerative Disc Disease

The purpose of this study is to evaluate the safety and effectiveness of XL TDR in patients with single-level degenerative disc disease compared to other devices approved by the FDA for the same or similar indications.

Completed35 enrollment criteria

Evaluation of the Safety and Efficacy of Smart Orthopedic Minimally Invasive Surgical Systems for...

Spine DiseaseSpinal Fractures

To evaluate the safety and effectiveness of the intelligent orthopedic minimally invasive surgery system developed by Shenzhen Xinjunte Intelligent Medical Equipment Co., Ltd. in spinal surgery.

Completed2 enrollment criteria
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