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Active clinical trials for "Spondylarthritis"

Results 331-340 of 566

Mechanism of Action of Anti-IL17 Therapy in Peripheral Spondyloarthritis

Spondylarthropathies

The purpose of this study is to determine the mechanism of action on target tissue level of anti Interleukine-17 (anti-IL-17) an therapy in peripheral spondyloarthritis. Patients will be treated with anti-IL-17 therapy (secukinumab) for 12 weeks and with a 2 year extension period thereafter. At week 0 and 12 peripheral blood, synovial tissue and skin will be analysed with different techniques, including immunohistochemistry, RNA analysis and tissue culture to assess the effect of the therapy on inflammatory pathways.

Completed8 enrollment criteria

Exercise Therapy in Patients With Axial Spondyloarthritis

Axial SpondyloarthritisInflammatory Disease1 more

Regular exercise, such as brisk walking, has been shown to lower levels of indicators of inflammation in the blood in people with long term conditions. This includes people with heart disease, kidney disease and diabetes. Axial Spondyloarthritis (axSpA) is an inflammatory condition with prescribed medication focusing on reducing inflammation. However, the effect of exercise on indicators of inflammation in axSpA is unknown. The research study intends to investigate whether a 12-week period of regular exercise can have favourable effects on inflammatory markers in the blood.

Completed13 enrollment criteria

Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis

Ankylosing Spondylitis

The primary objective of this study is to evaluate the efficacy of safety of etanercept dose reduction combined with sulfasalazine in ankylosing spondylitis (AS) patients who have achieved a significant clinical response.

Unknown status22 enrollment criteria

A Pilot Study of MSCs Iufusion and Etanercept to Treat Ankylosing Spondylitis

SpondylitisSpondylitis8 more

The purpose of this study is to evaluate the safety and clinical effect of mesenchymal stem cells (MSCs) derived from human bone marrow at a dose of 1.0E+6 MSC/kg in subject for the therapy of Ankylosing spondylitis (AS) and to compare the efficacy of MSCs and Etanercept to treat this disease.

Unknown status11 enrollment criteria

Etanercept (Enbrel) in Undifferentiated Spondyloarthritis

Spondyloarthritis

The study has the aim to investigate the efficacy and safety of etanercept in patients with active undifferentiated spondyloarthritis (uSpA) over the period of 520 weeks.

Unknown status23 enrollment criteria

Study Evaluating the Safety of Etanercept in Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriatic...

Ankylosing SpondylitisArthritis5 more

This is a Phase 4 open label, non-interventional, multi-center study to evaluate the safety of Enbrel (etanercept) treatment in patients receiving etanercept 25mg sc twice weekly or 50mg of etanercept once weekly. The improvement of health-related quality of life will also be evaluated.

Terminated11 enrollment criteria

Examination of Radiographic Progression, Efficacy and Safety of Long-Term Treatment With Infliximab...

Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory disease that involves the sacroiliac joints, axial skeleton, entheses and peripheral joints. Current therapy for AS is mainly NSAIDs and physiotherapy which are oft insufficient. Treatment with the TNF-alpha blocking agent infliximab was shown to have definite clinical efficacy in patients with active AS on a short- and a long-term-basis over 2 years. We want to show that treatment with infliximab on a long-term basis over 4 years is safe and efficient and can prevent radiographic progression over a long period of time. Further we want to learn about the outcome after discontinuation of anti-TNF-alpha therapy.

Unknown status16 enrollment criteria

SarS-Cov-2 Viral Infection (COVID-19) in Patients With Chronic Inflammatory Rheumatism

SpondyloarthritisRheumatoid Arthritis1 more

The purpose of this study is to assess whether immunosuppressive therapies used by patients with chronic inflammatory rheumatic diseases have an impact on the viral load and the humoral and cellular responses during viral infection with SarSCoV2, compared to members of their family cluster infected with the same viral strain.

Terminated15 enrollment criteria

An Observational Study of Infliximab in Participants Suffering From Ankylosing Spondylitis With...

SpondylitisAnkylosing

The purpose of this observational (a study that follows participants forward in time) study is to compare the functional improvement of hip joint using Harris hip score between 2 treatment groups (infliximab and conventional therapy) at Week 30 in ankylosing spondylitis (an autoimmune disease causing chronic inflammation at tendon ends and ligament attachment points) participants with hip involvement.

Terminated8 enrollment criteria

Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch...

Ankylosing Spondylitis

To determine the safety and efficacy of switch effects to adalimumab in etanercept-treated AS patients.

Unknown status9 enrollment criteria
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