Effects of Different Driving Pressure on Lung Stress, Strain and Mechanical Power in Patients With...
ARDSDriving Pressure3 moreARDS is the most common acute respiratory failure in the ICU and the mortality rate is still as high as 40%. Mechanical ventilation(MV) is the major supportive treatment for ARDS, but inappropriate ventilator setting could lead to patients suffering from Ventilator-Induced Lung Injury(VILI). VILI is an important factor in the aggravation of lung injury during MV. The main mechanism of VILI is the unreasonable pressure change (stress) causing excessive local stretch of the lung (strain), which eventually exceeds the capacity of the lung. The protective strategies during MV (limited platform pressure, low tidal volume, suitable PEEP) are important means of avoiding VILI during MV. The essences of these strategies are to limit the stress and strain of the lung during MV. However, these lung protective ventilation strategies only start from a single indicator and have certain limitations. Considering the various shortcoming of the current strategies, Amato et al. combined two indicators and proposed the concept of driving pressure(driving pressure=tidal volume/respiratory compliance). Several studies also confirmed that limiting the driving pressure can significantly improve patients' outcomes. But the concept of driving pressure and its safety threshold have certain limitations. Taking into the limitations of existing low tidal volume, limited platform pressure, and restricted driving pressure strategies in lung protection ventilation, Gattinoni et al. first integrated the all factors such as driving pressure, respiratory rate, airway resistance, respiratory rate and PEEP together and the concept of mechanical power was formally proposed.There is a good correlation between mechanical power and lung strain in a certain PEEP range. Cressoni et al. demonstrated through animal experiments that excessive mechanical power during MV caused significant VILI in animals; Guérin et al. also found that mechanical power was closely related to patient outcome in patients with ARDS. Not only that, but Gattinoni reanalyzed Güldner's experimental data and found that mechanical power is more valuable in reflecting lung damage than driving pressure. Mechanical power is a good indicator of response to patient VILI. Therefore, the investigators hypothesized that only limiting the driving pressure during MV of patients could not achieve ideal lung protective ventilation. Mechanical power may be a better indicator of response VILI; and the safety threshold of driving pressure based on retrospective analysis may not be suitable for patients with severe ARDS, and a lower driving pressure can protect patients with severe ARDS. This study intends to use a single-center, self-controlled study design to reflect lung injury through stress and strain and mechanical work of the lungs, to verify the safety of different driving pressures for severe ARDS, and to further find a safer driving margin for patients with severe ARDS
Effect of Heart Rate on Left Ventricular Performance
Myocardial FunctionMyocardial StrainThe current study is aimed at determining the normal response to increasing heart rates. For this purpose, atrial pacing will be used to increase heart rate.
Study of Negative Emotion, Fear-Avoidance Belief and Quality of Life in Patients With Ankle Sprain...
Chronic Ankle SprainThis study intends to investigate the negative emotions, fear-avoidance beliefs, and quality of life in patients with chronic ankle sprains to explore the relationship between negative emotions such as anxiety and depression, fear-avoidance beliefs, and their impact on quality of life.
Electromyographic Assessment of the Shoulder Stabilizing Musculature in CrossFit® Athletes
Muscle StrainElectromyography1 moreThis is an observational analytical study of prevalent cases and controls.
Global Strain and Mechanical Dispersion May Predict Death and Ventricular Arrhythmias Better Than...
Left Ventricular Function Systolic DysfunctionThe aim of the study is to investigate if global strain and mechanical dispersion may predict death and ventricular arrhythmias better than ejection fraction(EF) in patients with myocardial infarction and heart failure regardless of cause.
Fetal Cardiac Function Evaluation With aCMQ-Strain Fetal (STRAIN)
Fetal Cardiac DisorderTo assess whether the aCQM-Strain ultrasound method allows a good analysis of fetal cardiac function. Establish normality parameters and compare it with fetuses with risk factors of cardiac dysfunction.
Acute Hamstring Strains in Danish Elite Soccer - Diagnosis and Biomechanical Tests
StrainsA common soft tissue injury in sports involving sprinting and jumping is the hamstring strain. In addition to the frequency of injury, hamstring injuries are also the most recurrent soft tissue injury occurring in sport. There is a need for further research concerning diagnosis and different prognostic parameters for the rehabilitating process. The aims for this study are: A longitudinal comparison of sonographic and MRI assessments of acute and healing hamstring injuries. A study investigating different biomechanical parameters in the process of determining whether a former hamstring injured soccer player is fully rehabilitated. We hypothesize that it is possible to use electromyography, muscle strength measurements and different tests on a force platform to help determine this issue.