Study to Assess the Safety of Nivolumab in the Treatment of Metastatic Melanoma, Lung Cancer, Renal...
Multiple Indications CancerThis is a post-marketing study of patients who started nivolumab as first- or second-line therapy for metastatic melanoma or as second-line therapy for metastatic squamous non-small cell lung cancer (SqNSCLC) , metastatic non-SqNSCLC, metastatic renal cell carcimona (RCC), or recurrent or metastatic squamous cell carcinoma of the head and neck cancer (SCCHN), or third-line therapy for classical Hodgkin lymphoma (cHL) in Mexico.
Monitoring Blood Flow and Metabolic Activity in Malignant Tissue of Head and Neck Region
Squamous Cell Carcinoma of Head and NeckThis study will investigate the ability of Lucerno Dynamics Lara sensor when placed on the palpable carotid artery (or femoral artery) to monitor blood flow following the injection of 18-FDG and to distinguish peak flow in tumor versus tissue uptake. Investigators will then assess if differences in tumor versus tissue correlates with tumor response.
Effectiveness in Head and Neck Cancer Detection Using Positron Emission Tomography (PET) Insert...
Squamous Cell Carcinoma of the Head and NeckWe have developed a prototype PET insert device that can be integrated into a clinical PET/computed tomography (CT) scanner to improve its image resolution to approximately 2.5 mm in all 3 dimensions within a reduced imaging field of view (FOV). This zoom-in imaging capability provides 6-fold improvement in volumetric image resolution over the current state-of-the-art clinical PET scanner, offering a tremendous opportunity for cancer imaging applications, in particular for those cases where a lymph node involvement will drastically alter the patient management plan. Accurate diagnosis and staging of head-and-neck cancer is known to be challenging because of the complex anatomy and large number of lymph nodes involved in this region. As a result, head and neck cancer imaging is an ideal candidate for evaluating the clinical usefulness of this novel imaging device.
Saliva-based Detection of CD44
Oral Cavity Squamous Cell CarcinomaOropharynx Squamous Cell Carcinoma2 moreThe purpose of this study is to test the ability of OncAlert™ to screen for cancer and the reappearance of cancer. OncAlert™ was developed by Vigilant Biosciences, a collaborator in this research study. OncAlert™ is an oral rinse which is spit into a cup and sent to a laboratory for analysis. OncAlert™ is considered experimental by the FDA because it is not approved for the screening of cancer.
The Diagnosis of NPC Using the Probe-based Confocal Laser Endomicroscopy
Nasopharyngeal CarcinomaSquamous Cell Carcinoma of the Head and NeckTo evaluate the use of probe-based confocal laser endomicroscopy (pCLE) in human nasopharyngeal mucosa for the differentiation of the nasopharyngeal squamous cell carcinomas.
Epigenetic Changes in Head and Neck Cancer
Head and Neck CancerSquamous Cell Carcinoma2 moreWith this study, the investigators will investigate the epigenetic changes, which may contribute to the development of head and neck squamous cell carcinomas.
The Diagnostic Value of PET/MRI in Head and Neck Cancer
Squamous Cell Carcinoma of Head and NeckHead and Neck Neoplasms1 moreThis study investigates the diagnostic value of PET/MRI for cervical lymph node metastases from head and neck squamous cell carcinomas.
Evaluation of OE-MRI in Patients With H&N Cancer
Head and Neck Squamous Cell CarcinomaAssessment of the use of oxygen enhanced MRI scanning in a cohort of patients with head and neck squamous cell carcinomas to identify areas of hypoxia with tumours and relate this to treatment outcomes.
Functional ImaGing of Heterogeneity in Head and Neck Tumors - Validation From Surgical Specimens...
Squamous Cell Carcinoma of the Head and NeckThe purpose of this study is to investigate if heterogeneity in head and neck squamous cell carcinoma as seen in functional imaging with PET/MR can be correlated to biologic heterogeneity in surgical specimens.
Role of Immune Activation in Response of Head and Neck Squamous Cell Carcinoma to Therapy
Head and Neck CancerOropharyngeal Cancer2 moreThe purpose of this study is to investigate the role of the immune system in the response of squamous cell cancers of the head and neck to treatment that includes radiation therapy. Current research demonstrates that several natural immune cells and molecules affect the way the body's immune system interacts with a cancerous growth. Some cancers may be related to infection with a virus, such as the Human Papilloma Virus (HPV). Studying the activity of the immune system in head and neck cancers, especially cancers related to HPV infections, can provide valuable information to better understand the body's interaction with cancer cells.