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Active clinical trials for "Migraine Disorders"

Results 761-770 of 1206

Randomized Trial to Evaluate the Effectiveness of a Mindfulness Based Intervention (MBSR) for Patients...

Migraine

Patients suffering from migraine will be randomly allocated to one of two different behavioral interventions: mindfulness based stress reduction (MBSR) an eight week intervention program based different meditation & yoga techniques and teaching information regarding the relationship between stress and health. into an active control group teaching three times within eight weeks relaxation techniques (progressive muscle relaxation PMR) and giving psychoeducation on migraine. The investigators will measure the frequency and intensity of migraine attacks before during and after the intervention as well as secondary variables on quality of life and psychological functioning. The hypothesis is that patients allocated to the MBSR intervention will reduce the frequency of their migraine attacks compared to the active control group and compared to their own baseline.

Completed12 enrollment criteria

A Study to Assess an Auto-injector Being Used to Treat a Migraine Attack

Migraine

The purpose of this research study is to evaluate an investigational auto-injector system for delivering sumatriptan under the skin for a single migraine attack. The study could take approximately 5 weeks and will include about 3 office visits to the study doctor, the patient will be contacted every 2 weeks until the patient experiences a migraine and uses the auto-injector. The last visit will be done by a telephone follow-up call.

Completed15 enrollment criteria

Eletriptan Provides Consistent Migraine Relief: Results Of A Within-Patient Multiple-Dose Study...

Migraine Without AuraMigraine With Aura

Evaluation of headache response at 2 hours for active treated attacks for increasing dose.

Completed6 enrollment criteria

Effect of Metoclopramide Versus Sumatriptan for Emergency Department Treatment of Migraine Headache...

Migraine Disorders

The purpose of this study is to determine which drug makes lower migraine headache

Completed13 enrollment criteria

Two Dose Levels of DFN-15 vs. Placebo in Patients With Migraine Headaches

Migraine

Crossover study of DFN-15 dose A versus DFN-15 dose B versus Placebo in the treatment of migraine headaches.

Completed31 enrollment criteria

A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent...

Migraine Disorders

This is a 60 week study including a double-blind phase followed by an open-label extension phase.

Completed12 enrollment criteria

AMG 334 20160172 Pediatric Migraine PK Study.

Migraine

AMG 334 20160172 Pediatric Migraine PK Study.

Terminated9 enrollment criteria

A Study of the Safety, Tolerability, Pharmacokinetics, And Effects On Histamine-Induced Wheal Of...

Migraine

PF-05180999 is a phosphodiesterase-2 inhibitor that is hypothesized to be able to reduce vascular permeability. The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and effects on histamine-induced wheal of single doses of PF-05180999 in healthy adult subjects. Histamine-induced wheals are biomarkers of vascular permeability.

Terminated7 enrollment criteria

Neurostimulation in Chronic and Episodic Migraine

Double-blind DesignSham-controlled1 more

Currently, successful prevention of migraine is not sufficiently achieved by (prophylactic) drug therapy. In contrast, neurophysiologically guided treatments might provide an alternative avenue, since these can normalize brain alterations without side effects. Transcranial direct current stimulation (tDCS) appears useful in the acute and prophylactic treatment of migraine, probably because of its modifying and re-balancing influence on neuronal activity. Yet, to test for the efficacy of tDCS in a clinically acceptable way, it is necessary to apply not only tDCS but also a "sham" placebo, which is often neglected in tDCS stimulation studies. Further, tDCS needs to be applied in a large (n > 20) sample of well-defined migraine patients, which would be advantageous, compared to previously published work. Monitoring sources of regional neuronal alterations in migraineurs prior and after tDCS is essential to investigate physiological mechanisms of tDCS. There is an increasing interest towards non-pharmacological treatment alternatives for migraine (and headache disorders) with reduced side effects to established prophylactic medications. The primary outcome of this project is to demonstrate that repetitive sessions of neurostimulation lead to a significant and permanent reduction of the primary symptom severity (i.e. migraine attacks) for patients suffering from chronic and episodic migraine. Since neurostimulation tools are nowadays accepted as therapeutic tools, our study might provide evidence that tDCS can be a non-pharmacological alternative for treating migraine.

Terminated5 enrollment criteria

Ginger Capsules for the Prophylactic Treatment of Migraine

Migraine

The main objective of the study is to evaluate ginger efficacy as an prophylactic treatment of migraine.

Completed10 enrollment criteria
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