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Active clinical trials for "Constriction, Pathologic"

Results 41-50 of 1124

Percutaneous Endoscopic Decompression for Lumbar Canal Stenosis

Lumbar Spinal StenosisSurgery

Lumbar spinal stenosis (LSS) is the most common spinal degenerative disease. For conservative treatment failure, open lumbar decompression and fusion surgery is the main surgical treatment. After decades of development, open lumbar decompression and fusion surgery has been the standard treatment. However, there are still people and conditions that cannot be covered, such as elderly people who intolerable surgery, severe osteoporosis, and re-stenosis at adjacent segments after fusion. Percutaneous spinal endoscopic lumbar spinal decompression technique could be performed under local anesthesia, soft tissue damage is minimized, and effective spinal decompression can be achieved. There are still some controversial points of LSS decompression under percutaneous endoscope surgery, such as the range of decompression, choice of approach, postoperative spinal stability, learning curve, surgical safety, long-term effects of endoscopic treatment of restenosis at adjacent segments after fusion surgery. The purpose of this study was to solve these controversial points. A multi-center, prospective registration study based on the real world is planned. The total sample size is about 600 cases (300 cases in endoscopic surgery group, 300 cases in open decompression and fusion group). The mid- to long-term clinical efficacy and safety were evaluated.

Recruiting2 enrollment criteria

Physical Therapy vs Surgical Decompression for Lumbar Spinal Stenosis

Spinal Stenosis

This is a randomized controlled multicenter trail comparing physical therapy to surgical decompression in patients with lumbar spinal stenosis. The 0-hypothesis is that there is no difference in the efficacy of structured physical therapy compared to surgical decompression. Our aim is to evaluate if physical therapy can serve as a nonsurgical alternative for patients with LSS, where the severity of symptoms indicates the need of surgical decompression.

Recruiting18 enrollment criteria

Coated Metal Ureteral Stent in the Treatment of Radiation Induced Ureteral Stricture

Ureteral StrictureHydronephrosis1 more

A prospective, multicenter and controlled study to observe the efficacy and safety of coated metal ureteral stent in the treatment of radiation induced ureteral stricture.

Recruiting5 enrollment criteria

Preventive Effect of Limited Decompression on Adjacent Segment Following Posterior Lumbar Interbody...

Degenerative Lumbar Spinal StenosisDegenerative Disc Disease1 more

This is a prospective single-center study. Patients requiring posterior lumbar interbody fusion (PLIF) for degenerative disease are prospectively enrolled and followed. Patients enrolled in this study have asymptomatic pre-existing spinal canal stenosis at adjacent segment. This study will focus on the effects of preventative limited decompression at adjacent segment.

Recruiting7 enrollment criteria

Evolut™ EXPAND TAVR II Pivotal Trial

Aortic Stenosis SymptomaticModerate Aortic Valve Stenosis

Obtain safety and effectiveness data to support indication expansion for the Medtronic TAVR System to include patients with moderate, symptomatic AS.

Recruiting28 enrollment criteria

A Clinical Trial to Evaluate the Safety and Efficacy of IBS Angel in Patients With Pulmonary Artery...

Pulmonary Artery Stenosis

This is a prospective, multi-center, single-arm clinical trial to evaluate the safety and efficacy of Iron Bioresorbable Scaffold System (IBS Angel) in patients with pulmonary artery stenosis.

Recruiting17 enrollment criteria

PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

Aortic StenosisCalcific1 more

This study objective is to establish the safety and effectiveness of the Edwards SAPIEN 3 / SAPIEN 3 Ultra / SAPIEN 3 Ultra RESILIA Transcatheter Heart Valve systems in subjects with moderate, calcific aortic stenosis.

Recruiting17 enrollment criteria

SOLARIS Peripheral PMCF Trial

Peripheral Arterial DiseaseIliac Artery Stenosis1 more

The objective of this clinical investigation is to evaluate, in a controlled setting, the long-term (up to 12 months) safety and efficacy of the Solaris Vascular Stent Graft (Scitech) in clinical settings when used according to the indications of the IFU.

Recruiting36 enrollment criteria

Effect of Limaprost in Combination With Transforaminal Epidural Steroid Injection

Lumbar Spinal Stenosis

The purpose of this study was to compare the effects of limaprost(Opalmon® ) on walking ability, low back pain and leg pain after transforaminal epidural steroid injection (TFESI) was administered compared to the placebo group.

Recruiting18 enrollment criteria

Cryospray Therapy for Benign Airway Stenosis

Stenosis Trachea

This is a clinical evaluation to assess the effectiveness of cryospray therapy used in addition to current standard of care endoscopic therapies in preventing short term recurrent airway stenosis with a multicentric outcome evaluation. The investigators hypothesize that the addition of SCT to standard endoscopic treatment of benign airway stenosis will result in decreased stenosis recurrence at 6 months as estimated by quantitative radiologic assessment of the stenotic volume.

Recruiting21 enrollment criteria
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