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Active clinical trials for "Death, Sudden, Cardiac"

Results 31-40 of 257

Is the Perfusion Index an Accurate Predictor of Return of Spontaneus Circulation in Out-of-hospital...

DeathSudden3 more

The purpose of this pilot feasibility study is to evaluate the ability of the Perfusion Index to predict the return to spontaneous circulation of the out-of-hospital cardiac arrest patient during cardiopulmonary resuscitation. The performance of the perfusion index will also be compared to the current gold standard, end-tidal CO2 (EtCO2).

Recruiting4 enrollment criteria

HeartStart HS1 Defibrillator* Event Registry

Sudden Cardiac Arrest

A Prospective study on the performance and safety of the HeartStart OnSite (Model M5066A) & HeartStart Home (Model M5068A) Defibrillator device data.

Recruiting6 enrollment criteria

Prediction of ARrhythmic Events With Positron Emission Tomography II

Sudden Cardiac ArrestIschemic Cardiomyopathy1 more

Sudden cardiac death continues to be a major contributor to mortality in patients with ischemic cardiomyopathy. While implantable defibrillators can prevent death from ventricular arrhythmias, our current approach to identify patients at highest risk primarily rests on demonstrating a reduction in left ventricular ejection fraction less than 35%. The purpose of this observational cohort study is to prospectively test whether this can be enhanced by quantifying the amount of sympathetic denervation, left ventricular end-diastolic volume or brain natriuretic peptide levels.

Recruiting12 enrollment criteria

Mayo AVC Registry and Biobank

Arrhythmogenic Right Ventricular CardiomyopathyCardiomyopathies15 more

Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous. Diagnosis and screening of blood-relatives is very difficult as the disease process can be subtle, but sufficient enough, so that the first event is sudden death. The Mayo Clinic AVC Registry is a collaboration between Mayo Clinic, Rochester, USA and Papworth Hospital, Cambridge University Hospitals, Cambridge, UK. The investigators aim to enroll patients with a history of AVC or sudden cardiac death which may be due to AVC, from the US and UK. Family members who are blood-relatives will also be invited, including those who do not have the condition. Data collected include symptoms, ECG, echocardiographic, MRI, Holter, loop recorder, biopsies, exercise stress testing, blood, buccal and saliva samples. Objectives of the study: Discover new genes or altered genes (variants) which cause AVC Identify biomarkers which predict (2a) disease onset, (2b) disease progression, (2c) and the likelihood of arrhythmia (ventricular, supra-ventricular and atrial fibrillation) Correlate genotype with phenotype in confirmed cases of AVC followed longitudinally using clinical, electrocardiographic and imaging data. Characterize desmosomal changes in buccal mucosal cells with genotype and validate with gold-standard endomyocardial biopsies

Recruiting12 enrollment criteria

Magnetocardiography (MCG) Parameters in the Prediction of Future ICD Therapy

DeathSudden2 more

A multi-centre observational cohort trial to identify Magnetocardiography (MCG) parameters in the prediction of future ICD therapy. To show a correlation between Arrhythmogenic features on MCG and future ICD therapies seen on ICD interrogation of patients at risk of SCD.

Recruiting8 enrollment criteria

The International SubcutaneouS Implantable Cardioverter Defibrillator Registry (iSuSI)

Sudden Cardiac Death

The entirely subcutaneous implantable defibrillator (S-ICD) (Emblem, Boston Scientific, Marlborough, MA, USA) was introduced as a new therapeutic alternative to the conventional transvenous ICD in 2009 and implantations are rapidly expanding since then.1 Implantation of the S-ICD seems to reduce implant-related perioperative complications such as pneumothorax, hematoma and cardiac tamponade. The aim of this multicenter registry is thus to assess the outcome of patients following an S-ICD implantation in a real-world setting.

Recruiting4 enrollment criteria

Better Mechanistic Understanding of and Risk Stratification for Ventricular Tachyarrhythmias Through...

Ventricular TachycardiaVentricular Arrythmia10 more

This study aims to evaluate the electrophysiological properties of the heart conduction system in patients with (increased risk of) ventricular tachyarrhythmias (VTA) and sudden cardiac arrest, and in a control cohort. The electrophysiological properties will be measured with the relatively new technique ECG-Imaging (ECGI). Moreover, clinical data of subjects will be gathered. By combining the data from the data gathering and the results of ECGI, the investigators hope to increase mechanistic understanding of and risk stratification for VTAs. The investigators aim to be able to identify patients at risk of an arrhythmic event, and aim for better treatment strategies in the future.

Enrolling by invitation12 enrollment criteria

Prediction of Mortality After CIED Implantation (PM-CIED)

Heart FailureSystolic1 more

The study aims to develop and validate predictive models for the mortality of patients receiving CIED (including CRT and ICD) implantation.

Recruiting2 enrollment criteria

The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest

Sudden Cardiac Death

Sudden cardiac death (SCD) remains a major cause of mortality within developed nations despite aggressive efforts to reduce its societal burden. Despite extensive clinical and genetic investigations, a subgroup of cardiac arrests remain unexplained, highlighting the potential contribution of additional cardiac conditions that may not be identified with contemporary diagnostic algorithms. The EPS ARREST study aims to evaluate the role of invasive electrophysiology study within this patient population.

Recruiting13 enrollment criteria

French National Registry of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator...

Tetralogy of FallotImplantable Defibrillator User3 more

National french registry of patients with tetralogy of Fallot and implantable cardioverter defibrillator.

Recruiting3 enrollment criteria
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