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Active clinical trials for "Blood Loss, Surgical"

Results 31-40 of 173

Thrombin in Cardiac Surgery

ThrombinHemostatic Disorder3 more

Coagulopathy, bleeding, and transfusion are common in cardiac surgical patients. Our collaborator has developed a novel point of care device that can be used to assess thrombin generation in real-time in cardiac surgical patients. The investigators will measure thrombin generation using our novel device and compare it to standard methods, while examining the association of thrombin parameters with bleeding and other clinical outcomes.

Recruiting2 enrollment criteria

TEG Use in Children Undergoing Procedures With High Anticipated Blood Loss

Surgical Blood LossSurgical Hemorrhage1 more

The research team proposes a prospective, observational study to better understand how TEG can be useful in guiding clinical practice in the Main OR for subject's undergoing high transfusion risk surgeries. Intraoperatively, transfusion of blood products is frequently required to restore oxygen carrying capacity, perfusion and improve coagulation. Both under and over transfusion pose significant risks, particularly to pediatric patients with small starting intravascular volumes. Thromboelastography (TEG) is a validated method of dynamically assessing intraoperative coagulopathy via functional assay. However, while FDA approved and widely used in the adult setting, TEG is not commonly utilized in the setting of bleeding pediatric patients. Recently, TEG has been made available at BCH for clinical purposes and is being used solely in the cardiac surgery setting. The investigators aim to provide TEG data for non-cardiac pediatric surgical cases with a high risk of intraoperative blood loss in order to assess the impact of this tool on intraoperative management.

Not yet recruiting14 enrollment criteria

Ideal Time of Oxytocin Infusion During Cesarean Section

Blood LossSurgical4 more

This study will evaluate if the timing of oxytocin administration in cesarean deliveries will affect the amount of maternal blood loss. Half of participants will receive oxytocin after delivery of the fetal anterior shoulder and the other half will receive oxytocin after delivery of the placenta. We hypothesize that administering oxytocin after delivery of the shoulder, will result in less overall maternal blood loss.

Terminated9 enrollment criteria

Efficacy and Safety of Aprotinin on Transfusion Requirements in Patients Undergoing Radical or Total...

Blood LossSurgical1 more

The purpose of this study is to assess if aprotinin (BAYA0128), given intravenously during your surgery, is safe and can help reduce the need for a blood transfusion during bladder surgery.

Terminated12 enrollment criteria

Study to Investigate the Effect of Aprotinin of Transfusion Requirements in Patients Undergoing...

Blood LossSurgical

Study to Investigate the Effect of Aprotinin of Transfusion Requirements in Patients Undergoing Surgical Procedures for Lung or Esophageal Cancer.

Terminated13 enrollment criteria

Adjunctive Application of BioFoam Surgical Matrix in Liver Surgery

Intraoperative Bleeding

This is a prospective, multicenter, randomized, controlled investigation. Subjects in which bleeding from the exposed parenchymal surface is observed intraoperatively following the ligature of vessels visible with the unaided eye will be randomized to an adjunctive application of BioFoam or a standard topical hemostatic agent (Gelfoam with thrombin, in the form of Gelfoam Plus) to the entire exposed parenchymal surface. Following primary treatment of the exposed parenchymal surface as prescribed by the randomization scheme, treatment sites will be visually evaluated for the continued presence of bleeding. The overall objective of this investigation is to collect clinical data concerning the safety and effectiveness of BioFoam used as an adjunct to conservative measures of achieving hemostasis, such as manual pressure, cautery, and ligation, for intraoperative capillary, arteriolar, and venular bleeding (5 second stack of 5 gauze surface "Bleeding Score" = 1b or 2, score to be validated) on newly resected liver parenchyma in hemodynamically stable (American College of Surgeons' Advanced Trauma Life Support Class I Hemorrhage) and non-coagulopathic patients in the open treatment of exposed liver parenchyma versus a standard topical hemostatic agent, Gelfoam Plus. It is not intended for traumatic liver injury. The investigation will be conducted at a maximum of three investigational sites.

Terminated31 enrollment criteria

Preoperative Hexakapron Reduces Bleeding in Bariatric Surgery

Intra-Operative Injury - OtherPost Operative Hemorrhage1 more

Prophylactic use of tranexamic acid to reduce intra and postoperative bleeding in primary sleeve gastrectomy procedures will be studied.

Terminated12 enrollment criteria

Evaluation of the Quantra QStat System in Obstetric Patients

Blood Loss MassivePost Operative Hemorrhage

This pilot study will assess the performance of the Quantra System with the QStat Cartridge versus standard of care coagulation testing in bleeding pregnant women at delivery.

Enrolling by invitation8 enrollment criteria

Study to Compare the Addition of Floseal to Our Standard of Care to Control Post Operative Bleeding...

Intraoperative BleedingPost-operative Bleeding

The purpose of this study is to compare Floseal to our standard of care (SOC) to decrease intraoperative and immediate post-operative bleeding.

Completed8 enrollment criteria

Efficacy of Peritonsillar Dexmedetomidine Infiltration for Postadenotonsillectomy Pain

Pain PostoperativeIntraoperative Hemorrhage

The purpose of the present study is the clinical assessment of the efficacy of preincisional peritonsillar infiltration of dexmedetomidine on postoperative pain relief in children undergoing adenotonsillectomy.

Completed2 enrollment criteria
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