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Active clinical trials for "Genetic Predisposition to Disease"

Results 51-60 of 190

Cancer Predisposition Testing by Family-based Whole-genome Sequencing (WGS) in Every Child With...

Neoplastic SyndromesHereditary2 more

Assessment of the utility of family-based (trio) whole-genome sequencing for cancer predisposition testing in sequential newly diagnosed paediatric and adolescent cancer patients

Recruiting7 enrollment criteria

Pancreatic Cancer Early Detection Consortium

Pancreas CancerPancreas Cyst2 more

The purpose of the Pancreatic Cancer Early Detection (PRECEDE) Consortium is to conduct research on multiple aspects of early detection and prevention of pancreatic ductal adenocarcinoma (PDAC) by establishing a multisite cohort of individuals with family history of PDAC and/or individuals carrying pathogenic/likely pathogenic germline variants (PGVs) in genes linked to PDAC risk for longitudinal follow up.

Recruiting24 enrollment criteria

Diagnostic Value of Exome/ Genome Sequencing, Conventional Methods in Rare Diseases and Familial...

Rare DiseasesGenetic Predisposition

For the retrospective data analysis, patients with genetic diseases of any age and, if available, other family members, for whom genetic analyzes were carried out between 10/2016 and 12/2020, should be included. This equates to approximately 13,000 records, minus combined analyzes in the same patient, an estimated 12,000 individuals.

Recruiting4 enrollment criteria

Genetic Predisposition to Breast and Ovarian Cancer: Prospective Study of BRCAx Gene Mutation

Breast CancersOvarian Cancers

Cohort of subjects carrying a BRCA gene mutation: genetic predispositions to breast and ovarian cancers

Recruiting7 enrollment criteria

Correlation of Genetic Susceptibility Genes to Inflammatory Bowel Disease in Chinese Han Population...

Gene AbnormalityInflammatory Bowel Disease1 more

The pathogenesis of IBD is still unclear, and the disease characteristics of IBD patients are affected by genetic susceptibility genes. Therefore, this study aims to explore the relationship between genetic susceptibility genes of IBD and the pathogenesis of IBD in Chinese Han population, in order to clarify the pathogenesis of IBD and provide basis for individualized treatment of IBD.

Recruiting2 enrollment criteria

Prostate Cancer Genetic Risk Evaluation and Screening Study

Prostatic NeoplasmProstate Cancer6 more

This study aims to define the natural history of men at high genetic risk for prostate cancer on the basis of specific germline genetic mutations or a positive family history and evaluate the utility of prostate MRI as a screening tool. The hypothesis is that this targeted population of men are at elevated risk of developing prostate cancer compared to the general population, and enhanced screening with MRI will enable early detection and diagnosis of potentially aggressive prostate cancer, characterization of the penetrance of specific mutations, and potentially identify new genetic risk mutations.

Recruiting9 enrollment criteria

Exploring the Genetics of Neuropathic Pain

Neuropathic PainGenetic Predisposition1 more

In the present study the investigators will search for new genetic variants relevant for the development of neuropathic pain.

Recruiting7 enrollment criteria

The China Neonatal Genomes Project

NewbornHereditary Disease3 more

The project will carry out the genetic testing of 100000 neonates in the next 5 years. The aim of the project is to construct the Chinese neonatal genome database, establish the genetic testing standard of neonatal genetic diseases, and promote the industrialization of neonatal genetic disease gene testing, improve the training system for genetic counseling.

Recruiting11 enrollment criteria

Assesment of Multiomics Profiles in Health and Disease.

Genetic Predisposition to Disease

This study will determine reference genomic, transcriptomic, proteomic and metabolomic profiles in Czech population and will evaluate its correlation with the disease phenotype.

Recruiting6 enrollment criteria

Gene Expression in Chronic Venous Leg Ulcers

Genetic Predisposition to DiseaseInflammation1 more

Chronic Venous Disease (CVD) is a widespread clinical condition widely spread in the western countries that may negatively impact the quality of life (QoL) of affected patients. Chronic venous leg ulcers (CVLUs) are the most severe form of CVD, and several genetic and molecular alterations have been studied in order to understand the progression of CVD towards CLVUs. Chronic inflammation is a key element in CVLUs onset, and recently T helper 17 (Th-17) cells, a subtype of pro-inflammatory T helper (CD4+) cells defined by the production of a cytokine signature of which IL-17 represents the progenitor, seem to be related to several chronic disease. The aim of this study is to evaluate Th17- Gene Expression profile in patients with CVD and CVLUs.

Recruiting3 enrollment criteria
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