Feeding and Swallowing Problems in Infants With Laryngomalacia
Feeding DisordersSwallowing Disorder1 moreObservational cross-sectional study Infants with laryngomalacia Feeding and swallowing assessment
Use and Acceptability Study of Swallis DSA™ Device for Distanced Swallowing Assessment for Older...
DysphagiaSWALL EHPAD is a multicenter, prospective study on the use and Acceptability Study of Swallis DSA™ Medical Device for Distanced Swallowing Assessment for Older Adults In Nursing Home
Rehabilitation Manometry Study
Oropharyngeal DysphagiaOropharyngeal dysphagia, or difficulty swallowing, is a devastating condition that affects physiological and psychosocial functioning in 1 in 25 adults. Many dysphagia treatments exist, but our ability to adequately measure treatment outcomes is limited. Pharyngeal high-resolution manometry (pHRM) directly measures swallowing pressures, providing an objective measurement of physiology that characterizes the basic mechanisms of swallowing. pHRM is well-poised to measure outcomes of dysphagia treatments due to its direct, objective, and reproducible measures of swallowing function. This proposed project will address a central hypotheses that objective swallowing measures (including (pHRM) will reveal treatment-mediated swallowing changes, will align with patient-reported outcome measures, and will be able to predict who will benefit from treatment. The investigators will follow a cohort of participants with oropharyngeal dysphagia as they undergo either pharyngeal strengthening therapy or relief of upper esophageal sphincter outlet obstruction at three time points: baseline, mid-treatment (4-6 weeks) and post-treatment (10-12 weeks). The investigators will compare participants to healthy controls using pHRM, videofluoroscopy, diet assessment, functional reserve tests, and patient-reported outcome measures.
QUantitative Assessment of Swallowing After Radiation (QUASAR)
Head and Neck CancerDysphagia3 moreTo use novel methods for quantitative analysis of VFSS (videofluoroscopic swallow study, also known as modified barium swallow) to study and compare dysphagia in patients treated for head and neck carcinoma with concurrent radiation therapy and chemotherapy (cisplatin) or targeted therapy (cetuximab) vs. immunotherapy (pembrolizumab, nivolumab, or durvalumab). Our hypothesis is that pharyngeal constriction will be greater (lower ratio) with concurrent immunotherapy compared to chemotherapy, as measured by the pharyngeal constriction ratio (PCR).
Improving Diagnostic Standards in Dysphagia
DysphagiaThe purpose of this research is to understand the normal function of swallowing and respiratory muscles in order to establish normal parameters. This will allow us to compare normal physiology and function of swallowing and breathing muscles to people with a medical history that would put them at risk for a swallowing problem. Our goal is to identify the best tests that can be quickly and easily administered to accurately detect swallowing impairment in adults. Involvement is limited to a single 2-hour evaluation.
Establishment of Voice Analysis Cohort for Development of Monitoring Technology for Dysphagia
Deglutition DisordersCollection of basic data to develop a technique for monitoring the state of dysphagia using voice analysis.
Pulmonary Health in Children With Down Syndrome
Down SyndromeDysphagia1 moreThe goal of the study is to learn more about tests that can assess lung health in children with Down syndrome.
Esophageal Impedance and Manometry Measurements and Dysphagia Symptom Scoring
DysphagiaEsophagealComparison of manometry measurements and EndoFlip Balloon measurements in patients with dysphagia and a known esophageal diagnosis
Randomized Study Regarding Preventive Jaw- and Swallowing Intervention for Patients With Head and...
Head and Neck NeoplasmTrismus1 moreThe study includes patients with tumors of the oropharynx, larynx and hypopharynx scheduled to receive radiotherapy with curative intent (+/- chemotherapy). The patients will be randomized into either an intervention group (performing a preventive jaw- and swallowing exercise protocol before and during radiotherapy) or a control group no performing a exercise protocol. All patients will be encouraged to eat or drink for as long as possible during the therapy. All patients will meet with a speech-language therapist weekly during radiotherapy.
Evaluation of the Functional Status of Jejunoplasty and Coloplasty and Its Impact on Quality of...
Quality of LifeDysphagiaThe goal of this prospective population-based cohort study is to assess: The evolution of the functional status of patients undergoing complex esophageal reconstruction Its impact on quality of life, depending on the type of conduit performed. Participants Will be asked to complete different quality of life questionnaires during every follow-up visit Will undergo additional tests to assess functionality