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Active clinical trials for "Tetralogy of Fallot"

Results 11-20 of 76

ALTERRA: SAPIEN 3 THV With the Alterra Adaptive Prestent

Pulmonary DiseaseTranscatheter Pulmonary Valve Replacement (TPVR)3 more

To demonstrate the safety and effectiveness of the Edwards Alterra Adaptive Prestent in conjunction with the Edwards SAPIEN 3 Transcatheter Heart Valve (THV) System in subjects with a dysfunctional right ventricular outflow tract/pulmonary valve (RVOT/PV) who are indicated for treatment of pulmonary regurgitation (PR). Following completion of enrollment, subjects will be eligible for enrollment in the continued access phase of the trial.

Active18 enrollment criteria

Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses...

Tetralogy of FallotVentricular Tachycardia1 more

Individuals with repaired Tetralogy of Fallot (rTOF) remain at risk for sudden cardiac death from ventricular tachycardia (VT). Transcatheter pulmonary valve replacement (TPVR) indications continue to broaden, yet its capability to reduce the risk of VT and sudden cardiac death remains unknown. Thus, in a cohort of participants with rTOF who are presenting for TPVR the investigators intend to: (1) quantify and localize right ventricular (RV) isthmuses with abnormal voltage and/or conduction velocity; (2) identify which RV isthmuses are at risk of being "jailed" by TPV prostheses; and (3) explore the feasibility of omnipolar technology to characterize wavefront directionality and differentiate slow conduction from conduction block.

Recruiting3 enrollment criteria

Contrast Enhanced Three Dimensional Echocardiographic Quantification of Right Ventricular Volumes...

Tetralogy of FallotPulmonary Insufficiency

We propose the novel integration of two echocardiographic technologies - three-dimensional echocardiography using semi-automated right ventricular analysis coupled with the administration of ultrasound enhancing agents - to improve the inter-rater reliability and accuracy of various measures of right ventricular size and function, compared with cardiac MRI.

Recruiting6 enrollment criteria

Myocardial FIbrosis in Repaired Tetralogy of FAllot- FIFA Study)

Congenital Heart DiseaseCongenital Heart Defect1 more

This study aims to study the correlation between biomarkers of myocardial fibrosis (extracellular volume fraction calculated by cardiac magnetic resonance imaging (MRI) (T1-mapping) and levels of molecular biomarkers of fibrosis) and adverse events in a population of patients with repaired tetralogy of Fallot.

Recruiting6 enrollment criteria

Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

Congenital Heart DiseaseTetralogy of Fallot

The study team will use small pieces of human hearts which are removed as part of a required surgical procedure to study different objectives. One of the objective is how calcium ions pass through the membrane of heart cells in order to tell the heart cell how much force to contract with when the heart beats. Investigators will also study the proteins and RNA of these pieces to determine how the newborn heart cells control their force of contraction differently from adult heart cells. Investigators hypothesize that infant hearts have different regulation of calcium entry than adult hearts. The study team also wants to study combinations of 3D cardiac spheres with multiple environmental cues that can improve functional and metabolic maturation of Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and generate a more clinically relevant cell model.

Recruiting5 enrollment criteria

Optical Tissue Identification for Myocardial Architecture

Ventricular Septal DefectComplete Atrioventricular Canal1 more

The goal of this study is to test the hypothesis that fiberoptic confocal microscopy (FCM) imaging during repair of common congenital heart defects is a useful adjunct for avoidance of conduction abnormalities.

Active15 enrollment criteria

Evaluation of the GORE PV1 Device in Patients With Pulmonary Valve Dysfunction

Heart DefectsCongenital3 more

This study will assess the safety and performance of the GORE PV1 Device for replacement of the pulmonary valve and reconstruction of the Right Ventricular Outflow Tract (RVOT).

Active7 enrollment criteria

French National Registry of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator...

Tetralogy of FallotImplantable Defibrillator User3 more

National french registry of patients with tetralogy of Fallot and implantable cardioverter defibrillator.

Recruiting3 enrollment criteria

Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot...

Tetralogy of Fallot

This study is being done to determine the mechanism(s) contributing to the onset of symptoms (i.e. shortness of breath and/or palpitations) as well as changes in right heart structure in patients with Tetralogy of Fallot (TOF).

Recruiting4 enrollment criteria

ALTERRA Post-Approval Study

Pulmonary Valve InsufficiencyComplex Congenital Heart Defect3 more

This study will monitor device performance and outcomes in subjects undergoing implantation of the Edwards SAPIEN 3 Transcatheter Pulmonary Valve System with Alterra Adaptive Prestent in the post-approval setting

Recruiting5 enrollment criteria
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