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Active clinical trials for "Aortic Aneurysm, Thoracic"

Results 111-120 of 127

Phase II Clinical Study of the Safety and Efficacy of the Relay Thoracic Stent-Graft

Thoracic Aortic AneurysmPenetrating Ulcers

This study is a continuation of the pivotal trial studying the safety and efficacy of the Relay thoracic stent-graft system to treat thoracic aortic aneurysms. Efficacy is being evaluated by the device-related adverse event rate of endovascular repair (via the Relay thoracic stent-graft) through 1 year. Safety is being evaluated by comparing major adverse events through 1 year in subjects treated with the Relay thoracic stent-graft to those who underwent surgical repair.

Approved for marketing9 enrollment criteria

National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions...

Marfan SyndromeTurner Syndrome14 more

The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). GenTAC established a registry of 3706 patients with genetic conditions that may be related to thoracic aortic aneurysms and collected medical data and biologic samples. The study ended in September 2016. Data and samples are available from NHLBI and requests should be made to BioLINCC. See the NHLBI website for more information: https://www.nhlbi.nih.gov/research/resources/gentac/.

Completed15 enrollment criteria

Point-of-Care Focused Cardiac Ultrasound in Assessing the Thoracic Aorta

Aortic AneurysmThoracic1 more

The purpose of this prospective study is to compare point-of-care focused cardiac ultrasound (FOCUS) to thoracic computed tomographic angiography (CTA) in the measurement of ascending aortic dimensions. We hypothesize that FOCUS will demonstrate good agreement with CTA in the measurement of ascending aortic dimensions and accurately detect dilation and aneurysmal disease.

Completed3 enrollment criteria

CTAG Dissection/Trauma Post Marketing Surveillance Japan

Thoracic Aortic AneurysmThoracic Aorta Injury1 more

Post Marketing Surveillance of the Conformable GORE® TAG® Thoracic Endoprosthesis

Completed10 enrollment criteria

Platelet Activity in Vascular Surgery for Thrombosis and Bleeding

Peripheral Vascular DiseasePeripheral Artery Disease9 more

The proposed PIVOTAL study will examine a panel of platelet/coagulation activity markers during the perioperative period. The goal is to develop a clinically useful assessment of platelet/coagulation activity for risk stratification that may ultimately serve as a target for therapeutic intervention. This study will enroll 200 patients with peripheral artery disease undergoing vascular surgery. PIVOTAL is funded by American Heart Association and is scheduled to begin enrollment in July 2013 for approximately two years.

Completed10 enrollment criteria

Overlay of 3D Scans on Live Fluoroscopy for Endovascular Procedures in the Hybrid OR

Abdominal Aortic Aneurysm (AAA)Thoracic Aortic Aneurysm (TAA)2 more

As endovascular procedures become more complex, there is a growing need for 3D image overlay to assist with device guidance and placement. Currently, a 3D image is typically created intra-operatively using 3D rotational angiography (3D-RA) or cone-beam CT (XperCT). This 3D image may then be overlaid on live fluoroscopy to provide 3D guidance information (Dynamic 3D Roadmapping). Philips Healthcare multimodality overlay products allows registration of a pre-acquired MR/CT or 3D rotational image to live fluoroscopy.

Completed16 enrollment criteria

Indexed Aortic Area in Bicuspid Aortic Valve Aortopathy

Thoracic Aortic AneurysmBicuspid Cardiac Valve

This study aims to determine the relationship between the cross-sectional aortic area/patient height ratio (indexed aortic area) and absolute aortic diameter in proximal thoracic aortic aneurysms associated with a bicuspid valve. This will shed light on whether aneurysms with smaller diameters than those recommended for surgical intervention by guidelines are still at risk of aortic complications attending an abnormally high indexed aortic area.

Completed6 enrollment criteria

Noninvasive Neuromonitoring of Surgery of the Thoracic Aorta

Cardiopulmonary ArrestAortic Aneurysm3 more

The aim of this prospective, explorative study of noninvasive neuromonitoring was to search potential and practical methods associated with neurological outcome in the perioperative and immediate postoperative setting of surgery of the thoracic aorta. These methods include abbreviated EEG monitoring, near-infrared spectroscopy, transcranial Doppler ultrasound and biochemical markers associated with neuronal damage.

Completed3 enrollment criteria

Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes

Marfan SyndromeLoeys-Dietz Syndrome3 more

The primary objective of this study is to determine whether specific patterns of circulating micro-ribonucleic acids (miRNAs) are associated with aortic aneurysm and dissection in patients with hereditary aortopathy syndromes. The most common of these syndromes is Marfan Syndrome (MFS), but several other recognized aortopathy syndromes are well characterized. The investigators propose the use of a simple blood test, from which miRNA profiles can be measured in individuals with aortopathy syndromes to be compared with miRNAs observed in a control population that has no known predisposition for aortic disease. The investigators hypothesize that microRNA profiles in individuals with Marfan syndrome, and related disorders, will be distinct from those seen in a control group. The investigators predict that up- or down-regulation of certain miRNAs will correlate with the presence and severity of aortic aneurysm, responses to medical therapy, and ultimately could be used to determine when an individual may be at risk of dissection.

Completed10 enrollment criteria

Intravascular Ultrasound (IVUS) in Complex Aortic Endovascular Interventions

Thoracic Aortic Aneurysm

The study aims to investigate the applicability of intravascular ultrasound (IVUS) in the endovascular therapy of juxta-, supra- and thoracoabdominal aortic aneurysms. The focus of the study is on the intraoperative and postoperative evaluation of the geometric data of bridging stentgrafts in terms of patency, occurrence of stenosis and/or kinking.

Completed5 enrollment criteria
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