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Active clinical trials for "Aortic Aneurysm, Thoracic"

Results 41-50 of 127

French Assessment of the Relay Plus and Relay NBS Plus Thoracic Stent-Graft

Pathology of the Thoracic AortaAneurysm Thoracic6 more

Stent treatment of thoracic aortic pathologies, including aneurysms, pseudo-aneurysms, dissections, intramural hematomas, penetrating ulcers and ruptures of the isthmus, seems to provide a likely benefit compared to surgery in terms of surgical mortality and severe morbidity. However, the data concerning the long-term fate of these stents are insufficient. For this reason, the French National Health Authority (HAS) requests a 5-year follow-up in relation to the renewal of insurance reimbursement for these stent-grafts. Therefore, this long-term observational study has been set up.

Active4 enrollment criteria

GORE® TAG® Thoracic Endoprosthesis French Mandatory Registry

Aortic AneurysmThoracic4 more

This is a French Registry mandated by the French National Health Authority assessing long-term (5-years) safety of the GORE® TAG® Thoracic Endoprosthesis treating diseases of the thoracic aorta.

Active5 enrollment criteria

Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic...

SedationRespiration2 more

The primary objective of this study is to test the hypothesis that time on the ventilator and ICU length of stay will be shorter in TAA patients given postoperative sedation with dexmedetomidine compared to those given standard sedation. Secondary endpoints are: requirement for sedatives vasoactive drugs incidence of postoperative delirium and cost analysis.

Terminated9 enrollment criteria

Male-female Differences in Immunohistological and Biomechanical Properties of the Thoracic Aorta...

Thoracic Aortic Aneurysm

Thoracic aortic aneurysms (TAA) result from progressive dilatation of the thoracic aorta and confer a risk for aortic dissection or rupture, which is associated with significant morbidity and mortality. In the Netherlands there are an estimated 200.000 adults with TAA, and annually 600 deaths after aortic dissection or rupture. There are clear differences in the incidence of TAA between men and women, with a higher incidence in men. Little is known on possible differences in outcome between male and female patients with Thoracic Aortic Aneurysm (TAA). Aortic disease is thought to affect men more frequently than women, and aortic growth is different between men and women. Current data suggest that women are at an increased risk of both dying from aortic dissection and having aorta-related complications compared to men (1). The mechanisms for these male-female difference in TAA outcome remain, however, unclear. The timing of preventive surgery is now not different for men and women, but gender-based cut-off values for maximal aortic diameter based on differences in vessel wall composition might be needed.

Active3 enrollment criteria

The Effect of Losartan in Bicuspid Aortic Valve Patients

Bicuspid Aortic ValveThoracic Aortic Aneurysm

The specific aims of this study are to: Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in individuals with bicuspid aortic valve and ascending aortic or aortic sinus measurements >40mm. Assess the effect on MMP levels during treatment with losartan, an angiotensin II receptor blocking agent. In the setting of losartan therapy for one year, evaluate the response of MMP levels in these patients, and clinical outcomes including effects on aortic growth rate

Terminated21 enrollment criteria

Post-Approval Clinical Study of the Talent Thoracic Stent Graft to Treat Thoracic Aortic Aneurysms...

Thoracic Aortic Aneurysms

The purpose of this study is to evaluate the long-term safety and effectiveness of the Talent Thoracic Stent Graft System for treatment of descending thoracic aneurysms (DTA)following U.S. market approval.

Terminated10 enrollment criteria

Bloodtranfusions After Aortic Surgery

HemorrhageThoracic Aneurysm

The purpose of this study is to answer the following question: Leads a primary coagulation corrected with a single dose of fibrinogen concentrate after ascending aorta-arc reconstruction to a decrease in the number of allogenic blood transfusions, compared to placebo?

Terminated2 enrollment criteria

Cerebral Hemodynamics and Microemboli During Placement of Relay®Branch Thoracic Stent-Graft System...

Thoracic Aortic AneurysmThoracic Aortic Dissection1 more

This is an observational cohort study addressing the incidence of cerebral microemboli and alterations of cerebral hemodynamic physiology of the Relay®Branch thoracic stent-graft system.

Enrolling by invitation7 enrollment criteria

Detection of Hypoxia in Human Thoracic Aorta Using Pimonidazole Hydrochloride

Aortic AneurysmThoracic

This is a prospective study designed to determine the safety and value of Hypoxyprobe-1 (pimonidazole hydrochloride (-HCl)) to detect levels of tissue hypoxia in patients presenting with ascending aortic aneurysm.

Suspended19 enrollment criteria

GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Type IV Thoracoabdominal...

Thoracoabdominal Aortic Aneurysm

This study will assess the initial feasibility of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis (TAMBE Device) in the treatment of Aortic Aneurysms Involving the Visceral Branch Vessels.

Completed24 enrollment criteria
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