Active clinical trials for "Tinnitus"

The purpose of this study is to prove the efficacy of the internet and smartphone application-delivered tinnitus retraining therapy (TRT).

This study investigates the effect of cervical physical therapy on tinnitus annoyance in patients with somatic tinnitus. This study specifically enrolls patients with co-varying tinnitus and neck complaints, with low-pitched tinnitus or patients who's tinnitus can be influenced by neck movements or positions. These inclusion criteria were chosen, since a prior study showed that these factors were good prognostic indicators for a positive treatment effect.

The investigators aim to study whether surgical resurfacing of the sigmoid sinus and jugular bulb will result in elimination of venous pulsatile tinnitus.

The objectives of the study will be 1) to develop and show the feasibility of an internet-based Reiki therapy as an intervention for tinnitus, 2) to deliver Reiki therapy for tinnitus as a potential treatment, 3) to maintain a meaningful cohort of participants over a 6-month protocol, and 4) to collect pilot data on the potential benefit of internet-based Reiki therapy on tinnitus-related quality of life. Patients will also be provided with information on other potential tinnitus therapies.

This study will involve collaborating with oncologists in the post-chemotherapy follow-up appointments. The participants who wish to consent to this study will then answer 3 short questionnaires (THI, HHIA and SF-36) about hearing loss, tinnitus and quality of life. The audiologist or the researcher, under the supervision of an audiologist, will then perform a simple, non-invasive hearing test on the participant. Should the participant have a hearing loss, they will be advise to seek help from their General Practitioner.

Studies have established that the somatosensory system of the upper cervical region and head can be intimately involved in tinnitus. Tinnitus can arise directly from a disorder of the head and upper neck via the somatosensory system. Our clinical experience and review of reports of various types of treatments support the hypothesis that treatment modalities involving the somatosensory system can benefit individuals whose tinnitus is likely on a somatosensory basis, namely people with symmetric hearing thresholds but asymmetric widely fluctuating tinnitus. However these previous studies did not (a) limit their treatment population to only people with tinnitus on a somatosensory basis and (b) did not assess their results by considering this tinnitus subpopulation separately from the entire group of tinnitus subjects they treated. Hence, the purpose of this study is to re-assess these treatments by targeting people whose audiograms can not account for their tinnitus, such as individuals with symmetric hearing thresholds but asymmetric widely fluctuating tinnitus

In 1986 The Medical Research Council estimated that 4 million UK adolescents were at risk of hearing damage from over-exposure to loud music from personal audio players (PAPs), gigs, clubs, pubs and festivals. Since that time social noise exposure is estimated to have tripled to 19% of young people. The European Commission commissioned a report that estimated 5-10% of personal audio player users are risking permanent hearing loss and tinnitus by listening to music at high volumes for more than 1 hour a day for 5 years or more. Up to 246 million PAPs were sold in Europe in 2008, and 200 million mobile phones, many of which now have built-in audio players. Nevertheless, a recent survey showed that only 8% of young people identify hearing loss as a health problem. The Royal National Institute for the Deaf (RNID) undertook two surveys of young people in the UK to analyse listening behaviours as part of their "Don't Lose the Music" campaign. As a consequence they offer listening advice given by flyers at events and online at the dedicated website. There have been no studies to confirm if such advice is effective in reducing noise exposure. Aim: This study will pilot a methodology for a randomised controlled trial to test the effectiveness of a publically-available online video in changing the listening habits of young music lovers i.e. reduce the volume and number of hours of exposure. Hypothesis: A video and adapted sound track demonstrating the experience of noise-induced hearing loss and tinnitus accessed online will change the listening habits of 18-25 year-olds.

Primary objective Determine whether there are meaningful changes in tinnitus outcomes following cochlear implantation in adults with bilateral severe-to-profound hearing loss. Secondary objectives Determine the prevalence, nature, and severity of tinnitus before cochlear implantation. Determine the incidence, nature, and changes in severity of tinnitus following cochlear implantation. Explore associations between tinnitus and changes in hearing, psychological health, cochlear implantation-related factors, and quality of life in cochlear implant recipients with and without tinnitus. Patient identification: Providers of cochlear implantation services on the National Health Service in the United Kingdom Standard questionnaires: Completed remotely by participants using a computer or other preferred electronic device. The sample will comprise adults determined as eligible to receive a unilateral cochlear implant on the National Health Service (NHS) in the United Kingdom (UK). Inclusion criteria 18 years or older. Determined to be eligible for unilateral cochlear implantation. Did not previously receive a cochlear implant in either ear. Sufficient written or spoken English to participate in study activities. Have access to internet or suitable device to complete online study questionnaires. Able to give informed consent. Exclusion criteria Significant difficulties preventing independent completion of study activities. This study involves no clinical interventions beyond cochlear implantation that will be already available to participants as part of their routine care pathway. Participants will undergo routine pre- and post-operative assessments as part of usual care. Online questionnaires will include standard instruments used to assess: Tinnitus and its characteristics, related socio-demographic, lifestyle and health-related factors, and access to tinnitus care as measured with the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESiT-SQ) Tinnitus impact as measured with the Tinnitus Functional Index (TFI) Tinnitus-related psychological symptoms including anxiety as measured with the Patient Health Questionnaire (PHQ-9) mood as measured with the Generalised Anxiety Disorder Assessment (GAD-7) and insomnia as measured using the Insomnia Severity Index (ISI). Quality of life sensitive to changes in hearing as measured with the Health Utilities Index (HUI-3), and health and tinnitus as measured with the EuroQol Quality of Life Questionnaire (EQ-5D-5L) Hearing function (SSQ-12) The schedule of questionnaires will follow the schedule of routine clinical appointments as part of the cochlear implantation care pathway including a pre-operative baseline assessment, and 5 follow up assessments after the surgery to receive the cochlear implant, after first cochlear implant activation appointment, and after the 1-, 3- and 6-month appointments post-activation. The baseline questionnaire will require about 40 min to complete and follow up questionnaires about 15-30 min. Detailed analyses will be specified prospectively in a study analysis plan developed by the study team. Data analyses will be conducted by the study team with support from medical statisticians at the National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre (BRC) and/or the University of Nottingham. The software utilised for analyses may include Excel, SPSS, R or MATLAB. Mixed statistical methods will be used to characterise the sample and evaluate changes in the severity of tinnitus and patient-specific factors before and after implantation. Data analyses will include descriptive statistics, General/Generalised Linear Models (e.g., ANOVA, regression models) or non-parametric statistical methods where appropriate (e.g., Mann Whitney U test).

The hypothesis of the study is that the use of Cannabis will attenuate the tinnitus level as experienced by the patients.

This study will be conducted on patients with otosclerosis attending Assiut University Hospital and undergo stapedectomy operation Evaluation of each patient will conducted preoperatively and 3 month postoperatively Patient will undergo tinnitogram and tinnitus handicap questionnaire before and after the operation to measure improvement in hearing and tinnitus