Assessment Of Infrared Photobiotherapy for Improved Wound Healing
Wound HealingThe purpose of this study is to examine whether or not Low Level Laser Therapy (LLLT) can reduce pain and/or improve wound healing in patients with an acute traumatic injury to the upper extremity (wrist, forearm, or elbow).
Santyl vs. Sharp Debridement of Diabetic Foot Wounds
Diabetic Foot UlcersFoot WoundsThis study tests two different approaches to the removal of dead tissue from the surface of a wound.
The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients...
Acute Lung InjuryARDSThe investigators aim to study the specific elastance in ALI/ARDS patients during invasive mechanical ventilation.
Reparation of Cartilage Injuries in the Human Knee by Implantation of Fresh Human Allogenic Chondrocytes...
Cartilage Injuries in the Human KneeImplantation of fresh human allogenic chondrocytes in human knee cartilage injuries to obtain a repair and prevention of secondary osteoarthritis
Trauma Informed Intervention to Support Engagement in HIV Care Among MSM (THRIVE+)
HIV/AIDSTraumaThis purpose of this project is to specify and provide an initial test of a 10 session, individual-based cognitive therapy intervention to address symptoms of PTSD and poor engagement in HIV care among men who have sex with men (MSM) with trauma histories
Risk Factors and Machine Learning Model for Diuretics Related Acute Kidney Injury
Diuretic ToxicityAcute Kidney InjuryAcute kidney injury (AKI) is a series of clinical syndromes in which serum creatinine (Scr) concentrations increase over a short period of time, or urine output decreases. It has become an increasing global concern.Drug-induced acute kidney injury (D-AKI) refers to kidney injury caused by drugs or their metabolites within 7 days after the use of one or more drugs. The kidneys are rich in blood flow and have the function of acidifying the urine, making them an easy target for drug toxicity. Besides, there are enzymes in the kidney that metabolize some drugs, and if these drugs are metabolized abnormally in the kidney, substances toxic to the kidney may be produced.It was found that about 20% of AKI in hospitalized patients was caused by medications.Diuretics are one of the well-known nephrotoxic drugs, since they can directly or indirectly cause a significant decrease in renal blood perfusion and glomerular filtration rate through the mechanism of affecting tubulobulb feedback, which leads to kidney ischemia and hypoxia.However, there are few real-world studies on the incidence of AKI in hospitalized patients received diuretics. In this study, we aimed to explore the incidence and risk factors analysis of AKI in hospitalized patients received diuretics and develop the machine learning model for diuretics related AKI based on electronic medical record data. With the individual characteristics of patients, the risk of AKI can be evaluated before receiving diuretics, which may provide useful information for clinical decision making to better prevent D-AKI.
Nutrition Education for Cardiovascular Disease Prevention in Spinal Cord Injury
Spinal Cord InjuryThis is a randomized controlled trial to study a nutrition education intervention in individuals with spinal cord injuries both in the acute rehabilitation setting (n = 100) and the community setting (n = 100). Participants in the treatment group will receive six interactive nutrition lectures based upon a successful program that has been used in older adults titled "Eat Smart, Stay Well". The goals of intervention are to improve whole-grain, fruit and vegetable, and low-fat dairy intake and reduce fat and saturated fat intake. Secondary outcomes will include improvements in waist circumference of body mass index and some biomarkers such as cholesterol and blood sugar.
Ideal Anatomic Location for Saphenous Nerve Blocks: A Prospective Clinical Evaluation
Foot InjuryAnkle InjuryThis research is being done to compare two different saphenous nerve block locations and will help to determine which site best maintains knee strength and pain control.
Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury
Acute Lung InjurySepsisHypothesis 1A: Vitamin C infusion will significantly attenuate sepsis-induced systemic organ failure as measured by Sequential Organ Failure Assessment (SOFA) score, Hypothesis 1B: Vitamin C infusion will attenuate sepsis-induced lung injury as assessed by the oxygenation index and the VE40 Hypothesis 1C: Vitamin C infusion will attenuate biomarkers of inflammation (C-Reactive Protein, Procalcitonin), vascular injury (Thrombomodulin, Angiopoietin-2), alveolar epithelial injury (Receptor for Advanced Glycation Products), while inducing the onset of a fibrinolytic state (Tissue Factor Pathway Inhibitor).
Intravenous Exenatide in Patients With Acute Brain Injury
Brain InjuriesThe purpose of this study is to assess the feasibility of exenatide infusion for the treatment of high blood sugars following acute brain injury.