Efficacy and Neural Basis of Music-based Neurological Rehabilitation for Traumatic Brain Injury...
Traumatic Brain Injury (TBI)Traumatic brain injury (TBI) is one of the leading causes of serious, life-long disability among adolescents and young adults. Especially the cognitive, emotional, and motors deficits caused by TBI often impair everyday psychosocial functioning, quality of life and ability to work. The purpose of the study is to determine the long-term effect of music-based rehabilitation on cognitive, motor, emotional, and social recovery after TBI in adolescents and young adults, and to study the neural mechanisms that underlie behavioural recovery and the efficacy of music.
Life Improvement Following Traumatic Brain Injury
Traumatic Brain InjuryDepressionThe purpose of this study is to test the effectiveness of a telephone-based and in-person Cognitive Behavioral Therapy (CBT) intervention for treating Major Depressive Disorder (MDD) following Traumatic Brain Injury. Participants are randomly assigned to receive one of the following: 1) Telephone-based CBT, 2) In-person CBT, or 3) Usual care (control).
Erythropoietin in Traumatic Brain Injury (EPO-TBI)
Traumatic Brain InjuryThis study seeks to determine if erythropoietin alpha (EPO) administered to adult critical care patients with moderate or severe traumatic brain injury improves neurological function assessed at six months after injury.
Effectiveness of Amantadine Hydrochloride for Treatment of Severe Traumatic Brain Injury (TBI)
Traumatic Brain InjuryThis is a controlled trial of amantadine to improve level of function following severe traumatic brain injury. The purpose of this study is: To determine whether amantadine hydrochloride, given in a dose of 200-400 mg, improves functional recovery from the vegetative and minimally conscious states To determine whether amantadine-related gains in function persist following drug discontinuation To determine the safety profile of amantadine in patients with disorders of consciousness
Multidisciplinary Treatment in Patients With Mild Traumatic Brain Injury
Traumatic Brain Injury With Brief Loss of ConsciousnessThe aim of the study is to compare a multidisciplinary examination and follow up by rehabilitation program with a multidisciplinary examination, good advice and follow up by the family doctor. Further on we will examine if there were differing clinical characteristics between patients who attended a planned follow-up session and those that failed to and Prognostic factors in mild traumatic brain injury patients after discharge from hospital.
Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury.
Traumatic Brain InjuryGrowth Hormone (GH) deficiency, defined by insufficient GH response to a variety of stimulating compounds, is found in 20-35% of adults who suffer traumatic brain injuries (TBI) requiring inpatient rehabilitation1. However, there is no accepted gold standard for diagnosing GH deficiency in this population. Further, the major effector molecule of the somatotropic axis, Insulin-Like Growth Factor-1 (IGF-1) has recently been recognized as an important neurotrophic agent. Since most repair and regeneration after TBI occurs within the first few months after injury, absolute or relative deficiencies of GH and IGF-1 in the subacute period after TBI are potentially important factors why some patients fail to make a good functional recovery. The proposed study is a randomized, double-blind, placebo-controlled trial of rhGH, starting at 1 month post TBI, continuing for 6 months. This study has one primary hypothesis, that treatment with recombinant human Growth Hormone (rhGH) in the subacute period after TBI results in improved functional outcome 6 months after injury. As secondary hypotheses, we will investigate what is the optimal method to diagnose GH deficiency in TBI survivors and study the relationship between GH deficiency and insufficiency and functional recovery.
Safety of Darbepoetin Alfa Treatment in Patients With Severe Traumatic Brain Injury
Traumatic Brain InjuryThe purpose of this study is to see if the treatment of severely brain injured patients with darbepoetin (a long acting form of erythropoietin) will be safe, and will reduce brain damage by decreasing harmful levels of chemicals in the brain.
Carbamazepine for the Treatment of Chronic Post-Traumatic Brain Injury Irritability and Aggression...
Traumatic Brain InjuryThe purpose of this study is to determine if carbamazepine reduces irritability and aggression among individuals with traumatic brain injury
Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention
Traumatic Brain InjurySubarachnoid HemorrhageTo show that the use of intravenous levetiracetam(LEV;Keppra)for seizure prevention in patients in the Neuroscience Intensive Care Unit will result in fewer side effects compared to the current standard of care anticonvulsant and will be at least as effective as the current standard of care in preventing clinical and sub-clinical seizure activity.
Safety Study of AVP-923 in the Treatment of IEED (Involuntary Emotional Expression Disorder) Also...
Alzheimer's DiseaseStroke2 moreThe purpose of this study is to evaluate the long-term safety of AVP-923 in the treatment of Involuntary Emotional Expression Disorder (IEED) also known as Pseudobulbar Affect (episodes of uncontrolled crying and/or laughter).