Overcoming Membrane Transporters to Improve CNS Drug Delivery - Improving Brain Antioxidants After...
Pediatric Traumatic Brain InjuryThe overall purpose of this research study is to investigate the safety of pharmacological therapies that may potentially improve pediatric outcomes after traumatic brain injury. Traumatic brain injuries are the leading cause of death and disability among children and young adults. Hypothesis: Combinational therapy with a membrane transporter and antioxidant are safe after TBI and can overcome barriers to the brain and synergistically improve bioavailability and efficacy the antioxidant content of the body and CNS after TBI.
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury...
Brain InjuriesCraniocerebral Trauma3 moreThe investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI). The primary hypothesis is that adrenergic blockade after severe TBI will be associated with increased ventilator-free days.
Cognitive Therapy to Improve Word Finding
AnomiaAphasia2 moreAdults who sustain brain damage due to stroke, traumatic injury or surgery may develop difficulty finding words. This study compares the effectiveness of two behavior-based programs to improve picture naming ability in these individuals.
Progesterone Treatment of Blunt Traumatic Brain Injury
Traumatic Brain InjuryThe purpose of this study is to determine if progesterone treatment safely reduces brain swelling and damage after injury.
Therapeutic Hypothermia for Severe Traumatic Brain Injury in Japan
Brain InjuriesTraumaticThe purpose of this trial is to determine if mild hypothermia therapy, for severe head trauma patients, improves neurological outcome.
The DECRA Trial: Early Decompressive Craniectomy in Patients With Severe Traumatic Brain Injury...
Brain InjuriesThis is a multi-centre randomised trial to evaluate the effect of early decompressive craniectomy on neurological function in patients with severe traumatic brain injury. The primary outcome is neurological function measured at 6 months post injury using the Glasgow Outcome Score. Neurological function is qualified as proportion of favourable outcomes (Glasgow Outcome Score Extended [GOSE] grades 5-8).
Efficacy and Safety of Rivastigmine in Patients With Traumatic Brain Injury and Cognitive Impairment...
Traumatic Brain InjuryThis study is designed to investigate the efficacy and safety of rivastigmine compared with placebo in patients with traumatic brain injury and cognitive impairment.
Study of Oxycyte in Severe Closed Head Injury
Traumatic Brain InjuryBrain damage as a result of decreased oxygen to the brain is found in 80% of patients that die with severe head injuries. Laboratory studies in animals and clinical trials have shown that increasing oxygen in the brain results in better brain oxygen consumption, less cell death, and better functional outcome. This study will test the hypothesis that Oxycyte is an effective way to increase brain oxygen levels in severe head injury.
Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury
Traumatic Brain InjuryThe purpose of this study is to study the effects of EARLY (no more than 24 four hours from injury) administration of extra amounts of oxygen on traumatic brain injury.
Video Review of the Frequency and Assessment of Head Impacts During the FIFA World Cup 2022TM
Head InjuryConcussion2 moreThis is an exploratory observational study. Broadcasted video footage is used to review all head impacts during all 64 matches in the football tournament. All head impacts are registered, and simple descriptive statistics are used to create overviews of the head impact characteristics, including video signs of potential concussion, observed contact, location of the head impact, presence and timing of medical assessment, whether there was foul play and sanction, and if the player was substituted.