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Active clinical trials for "Depressive Disorder, Treatment-Resistant"

Results 101-110 of 336

A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat...

Treatment Resistant Depression

The primary objective of this study is to assess short, mid and long-term clinical outcomes in patients with difficult to treat depression (such as patients with treatment resistant depression) treated with Vagus Nerve Stimulation (VNS) Therapy as adjunctive therapy.

Recruiting6 enrollment criteria

CET- REM (Correlating ECT Response to EEG Markers)

ECTTreatment Resistant Depression

Single-center study to determine the relationship between changes in depression symptoms and electroencephalographic (EEG) patterns induced by electroconvulsive therapy (ECT)

Active3 enrollment criteria

Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant Depression

Major Depressive Disorder

The overarching goal of the present study is to evaluate the effect of a subanesthetic dose of ketamine 24-hour post-injection on resting state functional connectivity, cognitive control, and reward learning.

Recruiting23 enrollment criteria

The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant...

Treatment-resistant Depression

In this project, the investigators evaluate an accelerated schedule of repetitive transcranial magnetic stimulation for treatment-resistant depression. The investigators focuse on participants' brain activity and blood markers (Reelin, Apoer2, NMDAR, BDNF, exosomes and so on) to deepen the understanding of the mechanism of accelerated rTMS for treatment-resistant depression.

Recruiting11 enrollment criteria

rTMS Therapy for Treatment-Resistant Depression With Different Targets Guided by pBFS

MDDMajor Depressive Disorder1 more

To explore the effectiveness and safety of rTMS intervention with different targets in the left prefrontal cortex defined using the pBFS method, in adult patients with moderate and severe depressive disorder. Second, investigate the neural circuit that responds to the rTMS intervention using individualized brain image analysis, which may help to establish an effective target for the neuromodulation of patients with major depressive disorder.

Not yet recruiting21 enrollment criteria

Auditory MMN EEG in TRD in Response to Ketamine

Treatment-resistant Depression (TRD)

To develop and test a neurocomputational model of ketamine treatment response predictions in TRD.

Recruiting7 enrollment criteria

N2O for Acute Suicidality and Depression in the ED

Suicidal IdeationMajor Depressive Disorder1 more

Investigators are conducting this double-blind, randomized control trial (RCT), to compare inhaled N2O+ treatment as usual (TAU) versus inhaled placebo+TAU; demonstrating the feasibility and tolerability of the intervention in an emergency department (ED) setting on an acutely suicidal population.

Not yet recruiting11 enrollment criteria

Olfactory and Brain Stimulations in Treatment-resistant Depression

Treatment-resistant Depression

This is a prospective, randomized, double-blind, parallel-group controlled trial. The aim of this research project is to compare the clinical benefits achieved in patients with major depressive disorder (MDD) following two types of intervention: iTBS active alone or iTBS active combined with olfactory stimulations.

Not yet recruiting9 enrollment criteria

Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression

Treatment Resistant DepressionInflammation1 more

The goal of this clinical trial is to determine the impact of omega-3 fatty acids on the production of anti-inflammatory effects and clinical improvement in people with depression who have not responded well to standard antidepressant treatment. The main questions it seeks to answer are: Do omega-3 fatty acids added to ineffective antidepressant treatment increase production of compounds that reduce inflammation? Is the increase in these anti-inflammatory compounds associated with a stronger antidepressant effect? Participants taking antidepressants that have not worked completely will be assigned at random for a 12-week period to one of the following: an omega-3 preparation an inactive placebo During the course of the study, blood tests will be obtained for compounds associated with inflammation, and questionnaires to measure clinical improvement in depressive symptoms will be administered.

Not yet recruiting25 enrollment criteria

pBFS Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression

MDDMajor Depressive Disorder1 more

To explore the effectiveness and safety of rTMS intervention with different targets in the left prefrontal cortex defined using the pBFS method, in adult patients with moderate and severe depressive disorder. Second, investigate the neural circuit that responds to the rTMS intervention using individualized brain image analysis, which may help to establish an effective target for the neuromodulation of patients with major depressive disorder.

Not yet recruiting21 enrollment criteria
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