A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat...
Treatment Resistant DepressionThe primary objective of this study is to assess short, mid and long-term clinical outcomes in patients with difficult to treat depression (such as patients with treatment resistant depression) treated with Vagus Nerve Stimulation (VNS) Therapy as adjunctive therapy.
CET- REM (Correlating ECT Response to EEG Markers)
ECTTreatment Resistant DepressionSingle-center study to determine the relationship between changes in depression symptoms and electroencephalographic (EEG) patterns induced by electroconvulsive therapy (ECT)
Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant Depression
Major Depressive DisorderThe overarching goal of the present study is to evaluate the effect of a subanesthetic dose of ketamine 24-hour post-injection on resting state functional connectivity, cognitive control, and reward learning.
The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant...
Treatment-resistant DepressionIn this project, the investigators evaluate an accelerated schedule of repetitive transcranial magnetic stimulation for treatment-resistant depression. The investigators focuse on participants' brain activity and blood markers (Reelin, Apoer2, NMDAR, BDNF, exosomes and so on) to deepen the understanding of the mechanism of accelerated rTMS for treatment-resistant depression.
rTMS Therapy for Treatment-Resistant Depression With Different Targets Guided by pBFS
MDDMajor Depressive Disorder1 moreTo explore the effectiveness and safety of rTMS intervention with different targets in the left prefrontal cortex defined using the pBFS method, in adult patients with moderate and severe depressive disorder. Second, investigate the neural circuit that responds to the rTMS intervention using individualized brain image analysis, which may help to establish an effective target for the neuromodulation of patients with major depressive disorder.
Auditory MMN EEG in TRD in Response to Ketamine
Treatment-resistant Depression (TRD)To develop and test a neurocomputational model of ketamine treatment response predictions in TRD.
N2O for Acute Suicidality and Depression in the ED
Suicidal IdeationMajor Depressive Disorder1 moreInvestigators are conducting this double-blind, randomized control trial (RCT), to compare inhaled N2O+ treatment as usual (TAU) versus inhaled placebo+TAU; demonstrating the feasibility and tolerability of the intervention in an emergency department (ED) setting on an acutely suicidal population.
Olfactory and Brain Stimulations in Treatment-resistant Depression
Treatment-resistant DepressionThis is a prospective, randomized, double-blind, parallel-group controlled trial. The aim of this research project is to compare the clinical benefits achieved in patients with major depressive disorder (MDD) following two types of intervention: iTBS active alone or iTBS active combined with olfactory stimulations.
Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression
Treatment Resistant DepressionInflammation1 moreThe goal of this clinical trial is to determine the impact of omega-3 fatty acids on the production of anti-inflammatory effects and clinical improvement in people with depression who have not responded well to standard antidepressant treatment. The main questions it seeks to answer are: Do omega-3 fatty acids added to ineffective antidepressant treatment increase production of compounds that reduce inflammation? Is the increase in these anti-inflammatory compounds associated with a stronger antidepressant effect? Participants taking antidepressants that have not worked completely will be assigned at random for a 12-week period to one of the following: an omega-3 preparation an inactive placebo During the course of the study, blood tests will be obtained for compounds associated with inflammation, and questionnaires to measure clinical improvement in depressive symptoms will be administered.
pBFS Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression
MDDMajor Depressive Disorder1 moreTo explore the effectiveness and safety of rTMS intervention with different targets in the left prefrontal cortex defined using the pBFS method, in adult patients with moderate and severe depressive disorder. Second, investigate the neural circuit that responds to the rTMS intervention using individualized brain image analysis, which may help to establish an effective target for the neuromodulation of patients with major depressive disorder.