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Active clinical trials for "Undifferentiated Connective Tissue Diseases"

Results 11-17 of 17

"Overlap Syndrome and PSC: Evaluating Role of Gut Microflora and Its Identification With Antibiotics...

Primary Sclerosing CholangitisAutoimmune Hepatitis1 more

Based upon the possible implication of microbiota and abnormal microbial metabolites such as altered bile acids, in the pathogenesis of PSC, emerging data suggests that oral antibiotics, such as vancomycin and metronidazole, may have therapeutic effects in this overlap syndrome or PSC. The goal of our study is to evaluate role of antibiotics and microflora in children with AIH/PSC overlap syndrome or with PSC alone. The investigators hope to learn what effects oral antibiotics has on the bacteria present in stool, and hope to learn to characterize human intestinal microbial communities, in children suffering from overlap syndrome or PSC. The hypothesis of the investigators is that overlap syndrome and PSC develop due to altered microflora and the resulting abnormal bile acids pool. The outcome of overlap syndrome or PSC could be affected by presence or absence of RCUH. Antibiotics to correct the microflora may result in disease/cholangiopathy remission.

Completed7 enrollment criteria

Continuous Positive Airway Pressure Versus Noninvasive Ventilation in Patients With Overlap Syndrome...

Chronic Obstructive Pulmonary DiseaseObstructive Sleep Apnea1 more

The purpose of this study is to determine if Bipap should assume a standard-of-care role in the management of overlap syndrome.

Unknown status18 enrollment criteria

Immunosuppressant Regimens for Living Fetuses Study

Undifferentiated Connective Tissue DiseaseRecurrent Pregnancy Loss

Undifferentiated connective tissue diseases (UCTD) are known to increase the risk of pregnancy morbidities, including recurrent pregnancy loss. However, there is no consensus or guideline about the treatment for recurrent pregnancy loss in UCTD patients. Therefore, based on the tendency to thrombosis formation and placental inflammation in the pathogenesis of UCTD, this trial proposes to evaluate the effect of hydroxychloroquine with or without prednisone combined with anticoagulation on pregnancy outcomes in recurrent pregnancy loss patients with UCTD.

Unknown status23 enrollment criteria

Continuous Positive Pressure Versus Bi-level in Overlap Syndrome

Overlap SyndromeNocturnal Hypoventilation

Continuous positive airway pressure (CPAP) became the established treatment for overlap syndrome (OS). It has been showed that the survival benefits of CPAP favored hypercapnic patients. When considering hypercapnic stable COPD patients, survival benefits occurred when the use of bi- level ventilation therapy was targeted to significantly reduce hypercapnia. This highlights the relevance of hypercapnia and hypoventilation correction. Thus, the purpose of this study is to compare the use of CPAP to Bi-level ventilation in hypercapnic OS patients, since the later may correct not only the airway patency but also increase the magnitude of each breath.

Unknown status15 enrollment criteria

A Non-interventional Study to Investigate the Current Situation of Asthma-COPD Overlap Syndrome...

Asthma-COPD Overlap Syndrome

To investigate the distributions of the patients with ACOS, asthma and COPD over age 40 with chronic airflow limitation in China.

Completed2 enrollment criteria

Overlap FGIDs and Genetic Polymorphism

Functional Gastrointestinal DisordersOverlap Syndromes

To analyze the prevalence of overlap syndromes among NERD or RH, FD, and IBS patients, and to identify and to compare the differences in their characteristics and symptoms, and to determine their risk factors. To identify the differences in clinical features according to sex and gender. To analyze the effect of genetic polymorphisms on overlap FGIDs over long-term follow-up period.

Completed11 enrollment criteria

Initiation of Non- Invasive Ventilation at Home Versus Hospital Among Patients With Overlap Syndrome...

Overlap Syndrome

The study is based on the assumption that in the Overlap Syndrome, the introduction at home of the NIV is as effective in terms of compliance and clinical and gazometric improvement, and life quality, that setting hospital start up. The investigators will study the initiation of NIV at home versus in hospital in two randomized Overlap Syndrome patient groups. The main objective of the study is to demonstrate the non-inferiority of the initiation of the NIV at home versus hospital in terms of compliance.

Unknown status17 enrollment criteria
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