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Active clinical trials for "Depressive Disorder"

Results 1341-1350 of 5015

Riluzole Augmentation Pilot in Depression (RAPID) Trial

Major Depressive Disorder

The investigators are doing a research study to find out if riluzole, when taken along with a standard antidepressant (sertraline) can help people with major depression. This research study will compare riluzole + sertraline to placebo + sertraline. The investigators hypothesize that adding riluzole will lead to a better antidepressant response, in less time, then sertraline alone.

Terminated17 enrollment criteria

Online Self-help for Depressed Patients Awaiting Psychotherapy

Major Depressive Disorder

Patients with major depression who are on a waiting list for psychotherapy usually suffer from considerable symptoms. Online self-help is one potential way to alleviate this suffering. The investigators want to study if patients awaiting psychotherapy benefit from online-self help. The investigators therefore randomly assign patients to either online self-help or no intervention and assess their depressive symptoms on a regular basis. The investigators hypothesize that online self-help will be superior to no intervention in alleviating depressive symptoms in depressed patients awaiting psychotherapy.

Terminated6 enrollment criteria

Feasibility of a Technology-Based Treatment Support System

DepressionDepressive Disorder1 more

This study aims to evaluate a technology-based treatment support system for patients undergoing the treatment of depression. The investigators will explore the usefulness of the technology-based treatment support system as an adjunct to psychotherapy for depression.

Terminated8 enrollment criteria

Chart Review of Patients Undergoing Ketamine Infusions

Major Depressive DisorderBipolar Disorder2 more

The Canadian Rapid Treatment Center of Excellence (CRTCE) is a healthcare facility principally focused on providing best practices of intravenous ketamine treatment to adult patients suffering from mental health conditions. The center focuses specifically on treating individuals suffering from major depression disorder, bipolar disorder, post-traumatic stress disorder and obsessive compulsive disorder as their primary diagnosis. Herein, this retrospective analysis aims to look at past data in order to further develop our understanding of ketamine in the use of psychiatry.

Enrolling by invitation17 enrollment criteria

Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements

DepressionMajor Depressive Disorder

The purpose of the current study is to perform a unified, homogeneous data collection protocol that includes a large cohort of patients undergoing different treatment options for Major Depressive Disorder (MDD) as an avenue for investigating optimal biomarkers for depression treatments on an individual patient level.

Enrolling by invitation55 enrollment criteria

Multi-Omic, Clinomic and Digitomic Attributes of Major Depression for Integrative Analytics

Major Depressive DisorderUnipolar1 more

The purpose of this research is to see if information from blood and data from smartwatches can be combined to help diagnose depression and determine if transitions between active depression and treated depression can be predicted.

Enrolling by invitation15 enrollment criteria

Nitrous TRD Bipolar Depression

Treatment- Resistant Bipolar DisorderBipolar Disorder1 more

Investigators will study approximately 64 patients with Treatment-Resistant Bipolar Depressive Disorder, defined as a failure of at least 1 antidepressants in the current depressive episode and 2 lifetime medication failures. The study will last approximately 6 to 8 weeks, involving randomization into one of two treatment groups receiving 3 one hour long inhalation treatments over a week.

Terminated13 enrollment criteria

Study of Repetitive Transcranial Magnetic Stimulation (rTMS) as Adjuvant Treatment for Depression...

Depression

The study will systematically investigate the use of repetitive transcranial magnetic stimulation (rTMS) in non-remitters of a selective serotonin reuptake inhibitor (SSRI) followed by a serotonin-norepinephrine reuptake inhibitor (SNRI) trial with the capacity to identify gene variants that predict rTMS response.

Terminated10 enrollment criteria

Stanford RAD-AT Study (Research on Anxiety and Depression - Anhedonia Treatment)

AnxietyDepression

This research study is aimed at understanding behaviors and brain circuits that relate to anxiety and depression. Our goal is to learn which circuits of the brain are involved in anxiety and how these circuits might affect daily functioning. This study has recently added an additional treatment component: participants undergo a 12 week course of either Pramipexole medication or rTMS therapy (explained below). The ultimate goal of the study is to offer participants experiencing anxiety and depression a treatment that is alternative to ones that have failed them in the past, and to apply the knowledge we gain from investigating the brain circuits involved in anxiety and depression to help personalize treatments. We invite anyone who has recently experienced any symptoms of anxiety and/or depression to participate (no diagnosis is required to participate).

Enrolling by invitation5 enrollment criteria

Time to Remission of Depressive Symptoms With Combined SSRI and Ramelteon

Major Depressive DisorderInsomnia

Hypothesis I: Patients in the SSRI + ramelteon treatment group will achieve remission (defined as an IDS-C30 score of 11 or less) more quickly than those in the SSRI + placebo group.

Terminated13 enrollment criteria
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